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m6A兔源多克隆抗体【液体】
N6-甲基腺苷(m6A)是RNA的一种转录后修饰。m6A修饰已在所有类别的RNA(rRNA、tRNA和mRNA)中被发现,并由一种进化保守的多亚单位酶,甲基转移酶如3(METTL3)催化。细胞和病毒RNA被甲基化已经有几十年的历史。最近的研究发现,mRNA主要是在停止密码子和长的内部外显子处被m6A修饰,这在小鼠和人类之间是保守的。新的证据表明,m6A在调节基因表达、替代剪接模式、下游信号(p53)以及细胞凋亡方面发挥着重要作用。mRNA中m6A修饰的调节与疾病有关,其中脂肪量和肥胖相关的(FTO)已被报道为肥胖风险基因。FTO是一种m6A去甲基化酶,导致FTO表达增加的多态性与身体质量和肥胖风险的增加有关。可重复性是推进科学发现和加速科学家下一次突破的关键。IVDSHOW正通过我们的一系列重组抗体、基因敲除验证的抗体和基因敲除细胞系引领潮流,所有这些都支持提高可重复性。来自出版物和Abreviews的应用和物种,如果没有在我们自己的实验室或我们供应商的实验室进行测试,则不在Abpromise保证范围内。
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Description
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Rabbit polyclonal to N6-methyladenosine (m6A)
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Host species
Rabbit
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Tested applications
Suitable for: Nucleotide Array
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Species reactivity
Reacts with: Human, Drosophila melanogaster
Predicted to work with: Mouse, Rat, a wide range of other species -
Immunogen
Chemical/ Small Molecule corresponding to N6-methyladenosine (m6A) conjugated to keyhole limpet haemocyanin.
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Positive control
- ab151230 was tested on a oligonucleotide array against RNA oligomers; N6-methyladenosine (m6A) and unmodified adenosine. 2Ome-RNA oligomers carry a methyl group at the 2’-OH residue of the ribose molecule, making them resistant to most ribonucleases.
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Form
Liquid
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Storage buffer
pH: 7.40
Constituent: PBS PBS prepared using DEPC-treated water.
The use of RNase inhibitor is recommended. -
Concentration
- 100 µg at 1 mg/ml
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Purity
Immunogen affinity purified
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Clonality
Polyclonal
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Isotype
IgG
产品组分
内容 |
型号 |
规格 | 价格 |
储存温度 |
m6A兔源多克隆抗体【液体】 | ab151230 | 100ug | 6516.00 | -20°C |
操作手册 |
1 | 1 |
常温 |
操作手册
文件下载 | 文件内容 | 资源说明 |
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ab151230-m6A兔源多克隆抗体【液体】 | 操作手册 |
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ab151230-m6A兔源多克隆抗体【液体】相关说明 | 宣传单页 |
注意事项
保存建议 | 推荐蓝冰或冰袋运输。当您收到产品后,按照说明书建议保存各组分。 |
FAQ
条件。
Zhang H et al. Dynamic landscape and evolution of m6A methylation in human. Nucleic Acids Res 48:6251-6264 (2020).PubMed: 32406913
Ban Y et al. LNCAROD is stabilized by m6A methylation and promotes cancer progression via forming a ternary complex with HSPA1A and YBX1 in head and neck squamous cell carcinoma. Mol Oncol 14:1282-1296 (2020).PubMed: 32216017
Zhang X et al. N6-Methyladenosine Level in Silkworm Midgut/Ovary Cell Line Is Associated With Bombyx mori Nucleopolyhedrovirus Infection. Front Microbiol 10:2988 (2019).PubMed: 31998272
Song T et al. Zfp217 mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to promote adipogenic differentiation. Nucleic Acids Res N/A:N/A (2019).PubMed: 31037292
Liu XM et al. Programmable RNA N6-methyladenosine editing by CRISPR-Cas9 conjugates. Nat Chem Biol 15:865-871 (2019).PubMed: 31383972
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