您好,欢迎光临艾维缔科技怀来有限公司官方网站!
热线:0313-5935521
消退素D1
2 消退素D1 (RvD1) 是由 15-和 5-脂氧合酶对 DHA 的连续氧合作用产生的生理性物质1。3 RvD1 及其 17(R) 构型都能减少人类多形核白细胞(PMNL)的跨内皮迁移,这是急性炎症中最早发生的事件,其 EC50 值约为 30 nM。在小鼠腹膜炎模型中,RvD1 及其阿司匹林触发形式也表现出剂量依赖性减少白细胞浸润的作用,10-100 毫微克剂量的最大抑制率约为 35%。
Formal Name
7S,8R,17S-
CAS Number
872993-05-0
Synonyms
- 17(S)-
Resolvin D1 - RvD1
Molecular Formula
C22H32O5
Formula Weight
376.5
Purity
≥95%
Formulation
A solution in ethanol
Solubility
- DMF: 50 mg/ml
- Ethanol: 50 mg/ml
- PBS (pH 7.2): 0.05 mg/ml
λmax
302 nm
SMILES
CC/C=C\C[C@H](O)/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](O)C/C=C\CCC(O)=O
InChi Code
InChI=1S/C22H32O5/c1-2-3-9-14-19(23)15-10-6-4-5-7-11-16-20(24)21(25)17-12-8-13-18-22(26)27/h3-12,15-16,19-21,23-25H,2,13-14,17-18H2,1H3,(H,26,27)/b6-4-,7-5+,9-3-,12-8-,15-10+,16-11+/t19-,20+,21-/m0/s1
InChi Key
OIWTWACQMDFHJG-CCFUIAGSSA-N
产品组分
内容 |
型号 |
规格 |
储存温度 |
消退素D1 | 10012554-01 | 10ug | -20°C |
消退素D1 | 10012554-02 | 25ug | -20°C |
消退素D1 | 10012554-03 | 50ug | -20°C |
消退素D1 | 10012554-04 | 100ug | -20°C |
操作手册 |
1 | 1 |
常温 |
注意事项
保存建议 | 厂家推荐蓝冰运输。当您收到产品后,按照说明书建议保存于-20°C。 |
FAQ
Product Description References
1. Hong, S., Gronert, K., Devchand, P.R., et al. Novel docosatrienes and 17S-
2. Ariel, A., and Serhan, C.N. Resolvins and protectins in the termination program of acute inflammation. Trends Immunol. 28(4), 176-183 (2007).
3. Serhan, C.N., Hong, S., Gronert, K., et al. Resolvins: A family of bioactive products of ω-
4. Sun, Y.P., Oh, S.F., Uddin, J., et al. Resolvin D1 and its aspirin-
Product Citations
Archambault, A.-
Archambault, A.-
Recchiuti, A., Patruno, S., Mattoscio, D., et al. Resolvin D1 and D2 reduce SARS-
Hartling, I., Cremonesi, A., Osuna, E., et al. Quantitative profiling of inflammatory and pro-
Archambault, A.-
Meriwether, D., Sulaiman, D., Volpe, C., et al. Apolipoprotein A-
Krashia, P., Cordella, A., Nobili, A., et al. Author Correction: Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson’s disease. Nat. Commun. 10, 4725 (2019).
Kutzner, L., Rund, K.M., Ostermann, A.I., et al. Development of an optimized LC-
Chiang, N., Barnaeva, E., Hu, X., et al. Identification of chemotype agonists for human resolvin D1 receptor DRV1 with pro-
Bisicchia, E., Sasso, V., Catanzaro, G., et al. Resolvin D1 halts remote neuroinflammation and improves functional recovery after focal brain damage via ALX/FPR2 receptor-
Dalli, J., Colas, R.A., Walker, M.E., et al. Lipid Mediator Metabolomics via LC-
Lin, N., Shay, J.E.S., Xie, H., et al. Myeloid cell hypoxia-
Sasaki, A., Fukuda, H., Shiida, N., et al. Determination of ω-
免责申明:本网站销售的所有产品均不得用于人类或动物之临床诊断或治疗,仅可用于工业或者科研等非医疗目的。(获得国家相关部门批准的产品除外)
版权所有:艾维缔科技怀来有限公司 备案号:冀ICP备20011415号