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消退素D1
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10012554

消退素D1

消退素D1,Resolvin D1,15-LO 和 5-LO 作用于 DHA 的产物。更多视频请关注视频号【艾维缔】。哔哩哔哩【IVDSHOW】。抖音【军哥聊表观】。
10012554
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2 消退素D1 (RvD1) 是由 15-和 5-脂氧合酶对 DHA 的连续氧合作用产生的生理性物质1。3 RvD1 及其 17(R) 构型都能减少人类多形核白细胞(PMNL)的跨内皮迁移,这是急性炎症中最早发生的事件,其 EC50 值约为 30 nM。在小鼠腹膜炎模型中,RvD1 及其阿司匹林触发形式也表现出剂量依赖性减少白细胞浸润的作用,10-100 毫微克剂量的最大抑制率约为 35%。

Formal Name

7S,8R,17S-trihydroxy-4Z,9E,11E,13Z,15E,19Z-docosahexaenoic acid

CAS Number

872993-05-0

Synonyms

  • 17(S)-Resolvin D1
  • RvD1

Molecular Formula

C22H32O5

Formula Weight

376.5

Purity

≥95%

Formulation

A solution in ethanol

Solubility

  • DMF: 50 mg/ml
  • Ethanol: 50 mg/ml
  • PBS (pH 7.2): 0.05 mg/ml

λmax

302 nm

SMILES

CC/C=C\C[C@H](O)/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](O)C/C=C\CCC(O)=O

InChi Code

InChI=1S/C22H32O5/c1-2-3-9-14-19(23)15-10-6-4-5-7-11-16-20(24)21(25)17-12-8-13-18-22(26)27/h3-12,15-16,19-21,23-25H,2,13-14,17-18H2,1H3,(H,26,27)/b6-4-,7-5+,9-3-,12-8-,15-10+,16-11+/t19-,20+,21-/m0/s1

InChi Key

OIWTWACQMDFHJG-CCFUIAGSSA-N

产品组分

内容

型号

规格

储存温度

消退素D1 10012554-01 10ug -20°C
消退素D1 10012554-02 25ug -20°C
消退素D1 10012554-03 50ug -20°C
消退素D1 10012554-04 100ug -20°C

操作手册

1 1

常温

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10012554-消退素D1 操作手册
10012554-消退素D1相关说明 宣传单页

 

营销中心1

注意事项

保存建议 厂家推荐蓝冰运输。当您收到产品后,按照说明书建议保存于-20°C。

 

FAQ

Product Description References

1. Hong, S., Gronert, K., Devchand, P.R., et al. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. J. Biol. Chem. 278(17), 14677-14687 (2003).

2. Ariel, A., and Serhan, C.N. Resolvins and protectins in the termination program of acute inflammation. Trends Immunol. 28(4), 176-183 (2007).

3. Serhan, C.N., Hong, S., Gronert, K., et al. Resolvins: A family of bioactive products of ω-3 fatty acid transformation circuits by aspirin treatment that counter proinflammation signals. J. Exp. Med. 196(8), 1025-1037 (2002).

4. Sun, Y.P., Oh, S.F., Uddin, J., et al. Resolvin D1 and its aspirin-triggered 17R epimer stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. J. Biol. Chem. 282(13), 9323-9334 (2007).

Product Citations

Archambault, A.-S., Brassard, J., Bernatchez, É., et al. Human and mouse eosinophils differ in their ability to biosynthesize eicosanoids, docosanoids, the endocannabinoid 2-arachidonoyl-glycerol and its congeners. Cells 11(1), 141 (2022).

Archambault, A.-S., Zaid, Y., Rakotoarivelo, V., et al. High levels of eicosanoids and docosanoids in the lungs of intubated COVID-19 patients. FASEB J. 35(6), e21666 (2021).

Recchiuti, A., Patruno, S., Mattoscio, D., et al. Resolvin D1 and D2 reduce SARS-CoV-2-induced inflammatory responses in cystic fibrosis macrophages. FASEB J. 35(4), e21441 (2021).

Hartling, I., Cremonesi, A., Osuna, E., et al. Quantitative profiling of inflammatory and pro-resolving lipid mediators in human adolescents and mouse plasma using UHPLC-MS/MS. Clin. Chem. Lab. Med. 59(11), 1811-1823 (2021).

Archambault, A.-S., Zaid, Y., Rakotoarivelo, V., et al. Lipid storm within the lungs of severe COVID-19 patients: Extensive levels of cyclooxygenase and lipoxygenase-derived inflammatory metabolites. medRxiv (2020).

Meriwether, D., Sulaiman, D., Volpe, C., et al. Apolipoprotein A-I mimetics mitigate intestinal inflammation in COX2-dependent inflammatory bowel disease model. J. Clin. Invest. 130, 3670-3685 (2019).

Krashia, P., Cordella, A., Nobili, A., et al. Author Correction: Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson’s disease. Nat. Commun. 10, 4725 (2019).

Kutzner, L., Rund, K.M., Ostermann, A.I., et al. Development of an optimized LC-MS method for the detection of specialized pro-resolving mediators in biological samples. Front. Pharmacol. 10, 169 (2019).

Chiang, N., Barnaeva, E., Hu, X., et al. Identification of chemotype agonists for human resolvin D1 receptor DRV1 with pro-resolving functions. Cell Chem. Bio. 26(2), 244-254 (2019).

Bisicchia, E., Sasso, V., Catanzaro, G., et al. Resolvin D1 halts remote neuroinflammation and improves functional recovery after focal brain damage via ALX/FPR2 receptor-regulated microRNAs. Mol. Neurobiol. 55(8), 6894-6905 (2018).

Dalli, J., Colas, R.A., Walker, M.E., et al. Lipid Mediator Metabolomics via LC-MS/MS Profiling and Analysis. Clinical Metabolomics 59-72 (2018).

Lin, N., Shay, J.E.S., Xie, H., et al. Myeloid cell hypoxia-inducible factors promote resolution of inflammation in experimental colitis. Front. Immunol. 9(2565), (2018).

Sasaki, A., Fukuda, H., Shiida, N., et al. Determination of ω-6 and ω-3 PUFA metabolites in human urine samples using UPLC/MS/MS. Anal. Bioanal. Chem. 407(6), 1625-1639 (2015).

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