您好,欢迎光临艾维缔科技怀来有限公司官方网站!
热线:0313-5935521
5-羟甲基-dC
5-羟甲基-dC结构式
Shelf Life: 24 months after date of delivery
Molecular Formula: C10H15N3O5
Molecular Weight: 257.24 g/mol
Exact Mass: 257.10 g/mol
CAS#: 7226-77-9
Purity: ≥ 97 % (HPLC)
Form: solid
Color: white to off-white
Spectroscopic Properties: λmax 275 nm, ε 7.7 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Applications:
Epigenetic therapy[1,6]
Metabolism of dC substituted at position 5[2,3,5,7]
Influence on DNA promotor [4]
产品组分
内容 |
型号 |
规格 |
储存温度 |
5-羟甲基-dC | N1070-01 | 100mg | -20°C |
5-羟甲基-dC | N1070-02 | 500mg | -20°C |
操作手册 |
1 | 1 |
常温 |
注意事项
保存建议 | 厂家推荐蓝冰运输。当您收到产品后,按照说明书建议保存于-20°C。 |
FAQ
[1] Zauri et al. (2015) CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer. Nature 524:114.
[2] Guz et al. (2014) Comparison of the absolute level of epigenetic marks 5-methylcytosine, 5-hydroxymethylcytosine, and 5-hydroxymethyluracil between human leukocytes and sperm. Biol. Reprod. 91:55.
[3] Liu et al. (2013) Detection of oxidation products of 5-methyl-2'-deoxycytidine in Arabidopsis DNA. PLoS One 8:e84620.
[4] Schroeder (2014) Synthesis of a DNA promoter segment containing all four epigenetic nucleosides: 5-Methyl-, 5-hydroxymethyl-, 5-formyl-, and 5-carboxy-2'-deoxycytidine. Angew. Chem. Int. Ed. 53:315.
[5] Schiesser et al. (2013) Deamination, oxidation, and C-C bond cleavage reactivity of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxycytosine. J. Am. Chem. Soc. 135 (39):14593.
[6] El Sadafi et al. (2010) 5-Modified-2'-dU and 2'-dC as mutagenic anti HIV-1 proliferation agents: synthesis and activity. J. Med. Chem. 53 (4):1534.
[7] Madugundu et al. (2014) Hydroxyl-radical-induced oxidation of 5-methylcytosine in isolated and cellular DNA. Nucleic Acids Res. 42 (11):7450.
免责申明:本网站销售的所有产品均不得用于人类或动物之临床诊断或治疗,仅可用于工业或者科研等非医疗目的。(获得国家相关部门批准的产品除外)
版权所有:艾维缔科技怀来有限公司 备案号:冀ICP备20011415号