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总体DNA甲基化极易定量检测试剂盒(比色法)
总体DNA甲基化极易定量检测试剂盒(比色法)中含有定量检测全基因组甲基化所必需的所有试剂。在检测实验中,DNA被固定在一种有DNA吸附能力的孔上,甲基化的片段会被捕获试剂以及检测抗体识别,用酶标仪读取在450 nm处的OD值来定量。甲基化的DNA的量与OD值成线性关系,可以通过本试剂盒提供的方程来计算两种不同的甲基化DNA样品的相对甲基化状态或者通过标准曲线完全定量5-mc。基于其工作原理和微孔板模式,本试剂盒可以用于各种物种来源的多种样品形式,包括培养的细胞、新鲜和冷冻的组织、石蜡包埋组织、血浆/血清样品以及体液样品。
本试剂盒有以下优点和特性:
- 快速:减少的步骤,整个操作仅需要2小时;
- 稳定性:优化的试剂盒组分,允许在做复孔时,有更大的“触发信号”,尽量减少变化;
- 方便性:固定的低背景噪音,从而消除了DNA变性和板孔的限定性;
- 灵敏度:检测下限低至0.05%的甲基化DNA,输入量在100ng;
- 特异性:高效特异结合5-mC,在复孔的浓度范围内,对于未甲基化的胞嘧啶和羟甲基的胞嘧啶无特异性反应,仅对甲基化DNA(5-mC)进行高度专一的检测;
- 通用型:阳性与阴性对照,对于任何种属的甲基化DNA状态进行定量检测是非常理想的;
- 精确性:标准的阳性对照可以得到标准曲线,可以与HPLC-MS相媲美,用时短,效率高,。
- 灵活性:微孔板(96孔)的设计使实验更灵活,无论对于手动还是高通量分析简单、可信和检测实验条件恒始终如一。
产品组分
组分内容 |
型号:A-P-1030-48(48次) |
型号:A-P-1030-96(96次) |
储存温度 |
|
WB |
10X Wash Buffer |
14 ml |
28 ml |
4°C |
BS |
Binding Solution |
5 ml | 10 ml | 室温 |
NC |
Negative Control,0% 5-mC,50ug/ml * |
50 ul |
100 ul |
-20°C |
PC |
Positive Control,5% 5-mC,50ug/ml * |
10 ul |
20 ul |
-20°C |
mcAb |
5-mC Antibody,1000X* |
5 ul | 10 ul | 4°C |
SI |
Signal Indicator,1000X* |
5 ul | 10 ul | -20°C |
ES |
Enhancer Solution,1000X* |
5 ul | 10 ul | -20°C |
DS |
Developer Solution |
5 ml | 10 ml | 4°C |
SS |
Stop Solution |
5 ml |
10 ml |
4°C |
8-联管 |
8-Well Assay Strips(With Frame) |
6 |
12 |
4°C |
操作手册 |
|
1 |
1 |
室温 |
文件资源
文件下载 | 文件内容 | 资源说明 |
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A-P-1030-总体DNA甲基化极易定量检测试剂盒(比色法) | 操作手册 |
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A-P-1030-总体DNA甲基化极易定量检测试剂盒(比色法)相关说明 | 宣传单页 |
注意事项
保存建议 | 推荐蓝冰或冰袋运输。当您收到产品后,按照说明书建议保存各组分。 |
警告 | 本品仅供科研使用,请勿用于临床与诊断。 |
FAQ
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