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(-)-JQ1
Purity
≥98%
Format
Yellowish, white crystalline powder
Formula
C23H25ClN4O2S
MW
456.99
Solubility
Soluble in DMSO or ethanol at 100 mM
Biological Activity
(-)-JQ1 showed no inhibition of BRD4-dependent NMC cells.
CAS Registry #
1268524-71-5
Background
(-)-JQ1 is the inactive stereoisomer of the potent, cell-permeable, small molecule bromodomain inhibitor (+)-JQ1 that competitively binds to acetyl-lysine recognition motifs. (+)-JQ1 competitively binds to the bromodomain displacing the BRD4 fusion oncoprotein from chromatin, which induces squamous differentiation and specific anti-proliferative effect in BRD4-dependent cell lines and patient-derived xenograft models. However, study results have shown that (-)-JQ1 fails to significantly interact with any bromodomain tested and exhibits inhibition against BRD4(1) with and IC50 of 10,000 nM.
References
Filippakopoulos, P., et al. Nature. 2010 Dec 23;468(7327):1067-73.
Application Reference:
1. BET bromodomain inhibitors block growth of pancreatic cancer cells in three-dimensional collagen (2014)
2. Dual kinase-bromodomain inhibitors for rationally designed polypharmacology (2014)
产品组分
内容 |
型号 |
规格 |
储存温度 |
(-)-JQ1 | 27334 | 5mg | -20°C |
(-)-JQ1 | 27335 | 10mg | -20°C |
操作手册 |
1 | 1 |
常温 |
注意事项
保存建议 | 厂家推荐蓝冰运输。当您收到产品后,按照说明书建议保存于-20°C。 |
FAQ
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