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重组人PPARG蛋白
SYNONYMS
Peroxisome proliferator-activated receptor gamma, PPAR-gamma, PPARG, NR1C3, PPARG1, PPARG2.
INTRODUCTION
过氧化物酶体增殖物激活受体(PPARs)是核受体超家族中的配体激活转录因子,在脂肪生成、葡萄糖稳态和炎症中发挥重要作用。可分为三种不同的异型:α、β 和 γ。PPARg 主要在脂肪组织中表达,在结肠、免疫系统和视网膜中表达较少。PPARg 在肝脏中参与脂肪酸的分解代谢,而 PPARg 则影响脂肪组织中脂肪酸的储存,并在脂肪细胞分化中发挥作用。PPARg 与视黄醇 X 受体(RXR)以异二聚体的形式结合到 DNA 上,在与配体结合后激活目标基因的表达。
DESCRIPTION
Peroxisome Proliferator Activated Receptor Gamma Human Recombinant is expressed in E.coli having a molecular weight of 59.2 kDa and fused to an amino terminal hexahistidine tag.
SOURCE
Escherichia Coli.
PHYSICAL APPEARANCE
Sterile Filtered clear solution.
FORMULATION
The protein solution contains 20mM Tris-HCl and 50% glycerol.
STABILITY
Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
Avoid multiple freeze-thaw cycles.
PURITY
Greater than 90.0% as determined by SDS-PAGE.
SAFETY DATA SHEET
产品组分
内容 |
型号 |
规格 |
储存温度 |
重组人PPARG蛋白 | PKA-228-01 | 2ug | -80°C |
重组人PPARG蛋白 | PKA-228-01 | 10ug | -80°C |
重组人PPARG蛋白 | PKA-228-01 | 1mg | -80°C |
操作手册 |
1 | 1 |
常温 |
注意事项
保存建议 | 厂家推荐蓝冰运输。当您收到产品后,按照说明书建议保存于-20°C。 |
FAQ
Product Description References
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2. Dhasarathy, A., and Wade, P.A. The MBD protein family-
3. Hendrich, B., and Bird, A. Identification and characterization of a family of mammalian methyl-
4. Berger, J., and Bird, A. Role of MBD2 in gene regulation and tumorigenesis. Biochem. Soc. Trans. 33(Pt. 6), 1537-1540 (2005).
5. Ng, H.H., Zhang, Y., Hendrich, B., et al. MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. Nat. Genet. 23(1), 58-61 (1999).
6. Mian, O.Y., Wang, S.Z., Zhu, S.Z., et al. Methyl binding domain protein 2 (MBD2) dependent proliferation and survival of breast cancer cells. Mol. Cancer Res. 9(8), 1152-1162 (2011).
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