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组蛋白H3K4me3多克隆抗体
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ivdshowr

组蛋白H3K4me3多克隆抗体

组蛋白H3K4me3多克隆抗体,Histone H3K4me3 (H3K4 Trimethyl) Polyclonal Antibody,非常适合做DB,ChIP, ChIPseq,WB实验。更多视频请关注视频号【艾维缔】。哔哩哔哩【IVDSHOW】。抖音【军哥聊表观】。
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Application: ChIP, ChIP-seq, DB, WB
Areas of Research: Histone Methylation & Demethylation
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Broad Range, Human, Mouse, Rat

Background
Modulation of chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of DNA wound around eight core histone proteins (two each of H2A, H2B, H3, and H4), is the primary building block of chromatin. The amino-terminal tails of core histones undergo various post-translational modifications, including acetylation, phosphorylation, methylation, and ubiquitination. These modifications occur in response to various stimuli and have a direct effect on the accessibility of chromatin to transcription factors and, therefore, gene expression. In most species, histone H2B is primarily acetylated at Lys5, 12, 15, and 20. Histone H3 is primarily acetylated at Lys9, 14, 18, 23, 27, and 56. Acetylation of H3 at Lys9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms. Phosphorylation at Ser10, Ser28, and Thr11 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis. Phosphorylation at Thr3 of histone H3 is highly conserved among many species and is catalyzed by the kinase haspin. Immunostaining with phospho-specific antibodies in mammalian cells reveals mitotic phosphorylation at Thr3 of H3 in prophase and its dephosphorylation during anaphase.

Description
Histone H3K4me3 (H3K4 Trimethyl) Polyclonal Antibody. Unconjugated. Raised in: Rabbit.

Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Specificity
Broad Range, Mouse, Rat, Human

Isotype
IgG

Uniprot ID
Q16695

Purification
Affinity Purified

Immunogen
A synthetic trimethylated peptide around K4 of human histone H3 (NP_003520.1)

Storage
Shipped at 4°C. Upon receipt, store at -20°C. Avoid repeated freeze.

Alternative Names
H3K4me3 antibody, H3K4m3 antibody

Application
DB, WB, ChIP, ChIP-seq; Recommended dilution, DB 1:500 - 1:2000, WB 1:500 - 1:2000, ChIP 1:20 - 1:100, ChIP-seq 1:20 - 1:100

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组蛋白H3K4me3多克隆抗体 A-4033-025 25ul -20°C
组蛋白H3K4me3多克隆抗体 A-4033-050 50ul -20°C
组蛋白H3K4me3多克隆抗体 A-4033-100 100ul -20°C

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A-4033-组蛋白H3K4me3多克隆抗体 操作手册
A-4033-组蛋白H3K4me3多克隆抗体相关单页 宣传单页

 

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保存建议 厂家推荐蓝冰运输。当您收到产品后,按照说明书建议保存于-20°C。

 

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