8-羟基-2'-脱氧鸟苷-5'-三磷酸钠

8-羟基-2'-脱氧鸟苷-5'-三磷酸钠，8-Oxo-dGTP，8-Hydroxy-dGTP，8-Oxo-2'-deoxyguanosine-5'-triphosphate, Sodium salt，8-Hydroxy-2'-deoxyguanosine-5'-triphosphate, Sodium salt，8-氧-2'-脱氧鸟苷-5'-三磷酸钠。更多视频请关注视频号【艾维缔】。哔哩哔哩【IVDSHOW】。抖音【军哥聊表观】。

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IVDEpi

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NU1117

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内容	型号	规格	储存温度
8-羟基-2'-脱氧鸟苷-5'-三磷酸钠	NU1117-01	30ul(10mM)	-20°C
8-羟基-2'-脱氧鸟苷-5'-三磷酸钠	NU1117-02	150ul(10mM)	-20°C
操作手册		1	常温

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Selected References:
[1] Suzuki et al. (2010) Effect of base excision repair proteins on mutagenesis by 8-oxo-7, 8-dihydroguanine (8-hydroxyguanine) paired with cytosine and adenine. DNA Repair 9:542.
[2] Katafuchi et al. (2010) Critical amino acids in human DNA polymerases η and κ involved in erroneous incorporation of oxidized nucleotides. Nucleic Acids Res. 38:859.
[3] Nakamura et al. (2010) Structural and dynamic features of the MutT protein in the recognition of nucleotides with the mutagenic 8-oxoguanine base. J. Biol. Chem. 285:444.
[4] Raia et al. (2009) Continous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence. PNAS USA 106:169.
Yoshida H. et al. (2011) Increase in CpG DNA-induced inflammatory responses by DNA oxidation in macrophages and mice. Free Radic Biol Med. 51 (2):424.
Petrie et al. (2010) Deep sequencing analysis of mutations resulting from the incorporation of dNTP analogs. Nucleic Acids Res. 38 (22):8095.
Ramírez (2004) Gene of Bacillus subtilis Encodes a Functional Antimutator 8-Oxo- (dGTP/GTP)ase and Is under Dual Control of Sigma A and Sigma F RNA Polymerases. Journal of Bacteriology 186 (4):1050.
Zaccolo et al. (1999) The effect of high-frequency random mutagenesis on in vitro protein evolution: a study on TEM-1 beta-lactamase. Journal of Molecular Biology 285 (2):775.
Zaccolo et al. (1996) An Approach to Random Mutagenesis of DNA Using Mixtures of Triphosphate Derivatives of Nucleoside Analogues. Journal of Molecular Biology 255:589.
Kai et al. (2002) An oxidized nucleotide affects DNA replication through activation of protein kinases in Xenopus egg lysates. Nucl. Acids Res. 30 (2):569.
Canitrot et al. (2000) Nucleotide excision repair DNA synthesis by excess DNA polymerase beta: a potential source of genetic instability in cancer cells. FASEB J. 14 (12):1765.
Nampalli et al. (2000) Efficient synthesis of 8-oxo-dGTP: A mutagenic nucleotide. Bioorg. Med. Chem. Lett. 10 (15):1677.
Loeb et al. (1999) Lethal mutagenesis of HIV with mutagenic nucleoside analogs. Proc. Natl. Acad. Sci. USA 96:1492.

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