N4-Acetylcytidine

N4-Acetylcytidine，一种参与RNA修饰和基因表达调控的内源代谢产物。更多视频请关注视频号【艾维缔】。哔哩哔哩【IVDSHOW】。抖音【军哥聊表观】。

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N4-Acetylcytidine

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IVDEpi

目录号

C6648

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N4-Acetylcytidine是一种存在于生物体内的胞苷衍生代谢物，通过胞苷的乙酰基化形成。该分子作为RNA修饰组分之一，在RNA稳定性、翻译效率和基因表达调控中发挥作用。近年来研究发现，胞苷乙酰修饰与多种生理及病理过程相关，使N4-Acetylcytidine成为探索RNA修饰调控机制及生物功能的潜在工具，可用于RNA表观遗传学及相关疾病机制研究。

物理外观	Solid
CAS号	3768-18-1
分子式	C₁₁H₁₅N₃O₆
分子量	285.25
化学名称	N-(1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide
溶解度	≥52.6 mg/mL in DMSO; insoluble in EtOH; ≥5.24 mg/mL in H2O with ultrasonic
SMILES	CC(NC(C=C1)=NC(N1[C@@H]2O[C@@H]([C@H]([C@H]2O)O)CO)=O)=O
存储条件	-20°C
运输条件	蓝冰
SDF文件	Download SDF

产品组分

内容	型号	规格	储存温度
N4-Acetylcytidine	C6648-01	500mg	-20°C
N4-Acetylcytidine	C6648-02	1g	-20°C
操作手册		1	常温

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保存建议厂家推荐蓝冰运输。当您收到产品后，按照说明书建议保存于-20°C。
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Selected References:
Kamiya et al. (2004) Important amino acids in the phosphohydrolase module of Escherichia coli Orf135. Biochem Biophys Res Commun. 323 (3):1063.
Holliday et al. (2002) DNA methylation and epigenetic inheritance. Methods. 27 (2):179.
Kaito et al. (2001) Activation of the maternally preset program of apoptosis by microinjection of 5-aza-2'-deoxycytidine and 5-methyl-2'-deoxycytidine-5'-triphosphate in Xenopus laevis embryos. Dev Growth Differ. 43 (4):383.
Wong et al. (1997) A novel method for producing partial restriction digestion of DNA fragments by PCR with 5-methyl-CTP. Nucleic Acids Res. 25 (20):4169.
Chen et al. (1993) Direct induction of DNA hypermethylation in sea urchin embryos by microinjection of 5-methyl dCTP stimulates early histone gene expression and leads to developmental arrest. Dev Biol. 155 (1):75.
Gehrke et al. (1984) Quantitative reversed-phase high-performance liquid chromatography of major and modified nucleosides in DNA. J. Chromatogr. 301:199.
Eick et al. (1983) Quantitative determination of 5-methylcytosine in DNA by reverse-phase high-performance liquid chromatography. Anal. Biochem. 135:165.

The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cells

Cristina E. Requena, Guiomar Pérez-Moreno, ..., Dolores González-Pacanowska

Biochemical Journal | 2014 Mar 14