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利用脂质立方相（LCP）进行膜蛋白结晶已被证明是一种成功的方法，凭借其类膜天然环境，能从膜蛋白中获得高质量的衍射晶体[1]。
单油酸甘油酯是开展LCP结晶实验的首选脂质。然而，由于脂质的性质决定了LCP的性质，因此通过筛选不同脂质来改变LCP的特性是值得尝试的，尤其是在使用单油酸甘油酯的初始结晶尝试失败后[2,3]。
阴离子磷脂DSPG与单酰基甘油（MAGs）联合使用，可形成热力学稳定的超溶胀双连续立方相，其水通道比传统脂质介观相大五倍，适用于具有大胞外结构域的膜蛋白结晶[4]。
References
[1] Landau and Rosenbusch (1996) Lipidic cubic phases: a novel concept for the crystallization of membrane proteins. PNAS 93:14532.
[2] Caffrey (2015) A comprehensive review of the lipid cubic phase or in meso method for crystallizing membrane and soluble proteins and complexes. Acta Cryst F 71:3.
[3] Caffrey and Cherezov (2009) Crystallizing Membrane Proteins Using Lipidic Mesophases. Nat Protoc. 4(5):706.
[4] Zabara et al. (2018) Design of ultra-swollen lipidic mesophases for the crystallization of membrane proteins with large extracellular domains. Nat. Commun. 9:544.For research use only.
Description:
Host Lipid for protein crystallization in the Lipidic Cubic Phase (LCP) [1,2].
Once opened, use within 6 months. Purge the vial with nitrogen or argon after usage and store at -20°C.Shipping: shipped at ambient temperature
Storage Conditions: store at -20 °C
Shelf Life: 12 months
Molecular Formula: C21H40O4
Molecular Weight: 356.50
CAS#: 111-03-5
Purity: > 99 %
Solubility: Soluble in Hexane
Selected References:
[1] Caffrey (2015) A comprehensive review of the lipid cubic phase or in meso method for crystallizing membrane and soluble proteins and complexes. Acta Cryst F 71:3.
[2] Caffrey and Cherezov (2009) Crystallizing Membrane Proteins Using Lipidic Mesophases. Nat Protoc. 4 (5):706. -
产品组分
内容 型号
规格 储存温度
Monoolein(单油酸酯)
XLCP101-01 1g
-20°C Monoolein(单油酸酯)
XLCP101-02 2g
-20°C 操作手册
1 1 常温
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注意事项
保存建议 厂家推荐蓝冰运输。当您收到产品后，按照说明书建议保存于-20°C。 -
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