7.8MAG

Name: 7.8MAG
Brand: 艾德科技（北京）有限公司 专注于生物领域新产品新技术开发与应用

7.8MAG，1-(7Z-pentadecenoyl)-rac-glycerol，1-(7Z-十五碳烯酰基)-外消旋甘油。更多视频请关注视频号【艾维缔】。哔哩哔哩【IVDSHOW】。抖音【军哥聊表观】。

关键词

7.8MAG

所属分类

IVDEpi

目录号

XLCP106

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利用脂质立方相（LCP）进行膜蛋白结晶已被证明是一种成功的方法，凭借其类膜天然环境，能从膜蛋白中获得高质量的衍射晶体[1]。

单油酸甘油酯是开展LCP结晶实验的首选脂质。然而，由于脂质的性质决定了LCP的性质，因此通过筛选不同脂质来改变LCP的特性是值得尝试的，尤其是在使用单油酸甘油酯的初始结晶尝试失败后[2,3]。

阴离子磷脂DSPG与单酰基甘油（MAGs）联合使用，可形成热力学稳定的超溶胀双连续立方相，其水通道比传统脂质介观相大五倍，适用于具有大胞外结构域的膜蛋白结晶[4]。

References

[1] Landau and Rosenbusch (1996) Lipidic cubic phases: a novel concept for the crystallization of membrane proteins. PNAS 93:14532.
[2] Caffrey (2015) A comprehensive review of the lipid cubic phase or in meso method for crystallizing membrane and soluble proteins and complexes. Acta Cryst F 71:3.
[3] Caffrey and Cherezov (2009) Crystallizing Membrane Proteins Using Lipidic Mesophases. Nat Protoc. 4(5):706.
[4] Zabara et al. (2018) Design of ultra-swollen lipidic mesophases for the crystallization of membrane proteins with large extracellular domains. Nat. Commun. 9:544.

For research use only.

Description:
Host Lipid for protein crystallization in the Lipidic Cubic Phase (LCP)^[1-3].
Once opened, use within 6 months. Purge the vial with nitrogen or argon after usage and store at -20°C.

Shipping: shipped on dry ice

Storage Conditions: store at -20 °C

Shelf Life: 6 months

Molecular Formula: C₁₈H₃₄O₄

Molecular Weight: 314.46

CAS#: 1309764-71-3

Purity: > 99 %

Selected References:
[1] Caffrey (2015) A comprehensive review of the lipid cubic phase or in meso method for crystallizing membrane and soluble proteins and complexes. Acta Cryst F 71:3.
[2] Fowler et al. (2015) Gating Topology of the Proton-Coupled Oligopeptide Symporters. Structure 23:290.
[3] Li et al. (2013) Crystal structure of the integral membrane diacylglycerol kinase. Nature 497:521.
关键词:
- 7.8MAG