漆树酸(Anacardic Acid)

漆树酸(Anacardic Acid)，是从腰果壳中提取液中分离到的酸类物质，是一种组蛋白乙酰转移酶抑制剂，对 p300 和 PCAF 的 IC50值分别为 ∼8.5 μM 和 ∼5 μM。更多视频请关注视频号【艾维缔】。哔哩哔哩【IVDSHOW】。抖音【军哥聊表观】。

关键词

漆树酸(Anacardic Acid)

所属分类

抑制剂

目录号

T6389

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文献追踪

Anacardic Acid (6-pentadecylsalicylic Acid) 是从腰果壳中提取液中分离到的酸类物质，是一种组蛋白乙酰转移酶抑制剂，对 p300 和 PCAF 的 IC50值分别为 ∼8.5 μM 和 ∼5 μM。

生物活性

产品描述	Anacardic Acid (6-pentadecylsalicylic Acid) is an effective inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases. It also has antimicrobial activity, antibacterial activity, and inhibits prostaglandin synthase, lipoxygenase, and tyrosinase.
靶点活性	p300 HAT:8.5 μM, PCAF(p300/CREB-binding protein-associated factor):5 μM
体外活性	Anacardic acid作为多个临床靶向酶的抑制剂，例如HATs、NF-kB、LOX-1、黄嘌呤氧化酶、酪氨酸酶和尿素酶，并且在体外也是Tip60的有效抑制剂。它抑制了在HeLa细胞中Tip60依赖的ATM蛋白激酶的乙酰化和激活，从而使细胞对辐射的细胞毒性效应更加敏感。
体内活性	Anacardic Acid 通过减少暴露于乙醇的胎鼠心脏中Gata4、α-MHC和cTnT的过表达，抑制PCAF、P300与Gata4启动子的结合。
激酶实验	HAT and HDAC Activity Assays :After homogenization of cardiac tissues, nucleoproteins are extracted using a Nuclear Extract Kit according to the manufacturer's instructions. HAT and HDAC activities of the nuclear protein extracts are determined using a colorimetric assay included in the HAT and HDAC assay kits.
细胞实验	HeLa and 293T cells are grown in Dulbecco's modified Eagle's medium/10% fetal calf serum. SQ20B and SCC35 squamous cell carcinoma cell lines are cultured in modified eagles medium/10% fetal calf serum. For anacardic acid (EMD Biosciences, CA) exposure, cells are preincubated with anacardic acid (0-100 μM) for 40 min, irradiated, then allowed to recover for 4 h. Cells are then switched to fresh media and allowed to grow for 10 days.
动物实验	Animal Models: 9 to 11 week old Kunming mice. Formulation: Dissolved in DMSO,co-injected with ethanol. Dosages: 0,1.25,2.5,5,10 mg/kg. Administration: i.p.
别名	漆树酸, Hydroginkgolic acid, 6-pentadecylsalicylic Acid

化学信息

分子量	348.52
分子式	C₂₂H₃₆O₃
CAS No.	16611-84-0
Smiles	CCCCCCCCCCCCCCCc1cccc(O)c1C(O)=O
密度	1.002 g/cm3

产品组分

内容	型号	规格	储存温度
漆树酸(Anacardic Acid)	T6389-01	1mg	-20°C
漆树酸(Anacardic Acid)	T3969-02	5mg	-20°C
漆树酸(Anacardic Acid)	T3969-03	10mg	-20°C
漆树酸(Anacardic Acid)	T3969-04	25mg	-20°C
漆树酸(Anacardic Acid)	T3969-05	50mg	-20°C
漆树酸(Anacardic Acid)	T3969-06	100mg	-20°C
漆树酸(Anacardic Acid)	T3969-07	500mg	-20°C
操作手册	1	1	常温

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保存建议厂家推荐蓝冰运输。当您收到产品后，按照说明书建议保存于-20°C。
FAQ
1.Radde BN, et al.J Cell Biochem. 2016 Mar 17.

2.Yao K, et al.Int J Clin Exp Pathol. 2015 Dec 1;8(12):15926-32. eCollection 2015.

3.Peng C,etal.Inhibition of histone H3K9 acetylation by anacardic acid can correct the over-expression of Gata4 in the hearts of fetal mice exposed to alcohol during pregnancy.PLoS One. 2014 Aug 7;9(8):e104135.

4.Hemshekhar M,etal.Emerging roles of anacardic acid and its derivatives: a pharmacological overview.Basic Clin Pharmacol Toxicol. 2012 Feb;110(2):122-32.

5.Peng C, et al. Phenylephrine-induced cardiac hypertrophy is attenuated by a histone acetylase inhibitor anacardic acid in mice. Mol Biosyst. 2017 Mar 28;13(4):714-724.

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