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15(S)-HETrE 是二氢-γ-亚麻酸（DGLA；型号 90230）经 15-脂氧作用产生的羟基三烯酸。1 在 RBL 细胞中，15(S)-HETrE 可抑制 5-LO，但药效约为 15(S)-HpETE 的 1/20。
Formal Name
15S-
hydroxy- 8Z,11Z,13E- eicosatrienoic acid CAS Number
92693-02-2
Molecular Formula
C20H34O3
Formula Weight
322.5
Purity
≥98%
Formulation(Request formulation change)
A solution in ethanol
Solubility(Learn about Variance in Solubility)
- 0.1 M Na2CO3: 2 mg/ml
- DMF: Miscible
- DMSO: Miscible
- Ethanol: Miscible
- PBS pH 7.2: 0.8 mg/ml
λmax
236 nm
SMILES
CCCCC[C@@H](O)/C=C/C=C\C/C=C\CCCCCCC(O)=O
InChi Code
InChI=1S/C20H34O3/c1-2-3-13-16-19(21)17-14-11-9-7-5-4-6-8-10-12-15-18-20(22)23/h4-5,9,11,14,17,19,21H,2-3,6-8,10,12-13,15-16,18H2,1H3,(H,22,23)/b5-4-,11-9-,17-14+/t19-/m0/s1
InChi Key
IUKXMNDGTWTNTP-OAHXIXLCSA-N
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产品组分
内容
型号
规格 储存温度
15(S)-HETrE 36720-01 25ug -20°C 15(S)-HETrE 36720-02 50ug -20°C 15(S)-HETrE 36720-03 100ug -20°C 15(S)-HETrE 36720-04 500ug -20°C 操作手册
1 1 常温
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营销中心
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注意事项
保存建议 厂家推荐蓝冰运输。当您收到产品后，按照说明书建议保存于-20°C。 -
FAQ
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Product Description References
1. Petrich, K., Ludwig, P., Kühn, H., et al. The suppression of 5-
lipoxygenation of arachidonic acid in human polymorphonuclear leukocytes by the 15- lipoxygenase product (15S)- hydroxy- (5Z,8Z,11Z,13E)- eicosatetraenoic acid: Structure- activity relationship and mechanism of action. Biochem. J. 314, 911-916 (1996). 2. Haviv, F., Ratajczyk, J.D., DeNet, R.W., et al. Structural requirements for the inhibition of 5-
lipoxygenase by 15- hydroxyeicosa- 5,8,11,13- tetraenoic acid analogues. J. Med. Chem. 30(2), 254-263 (1987). Product Citations
Archambault, A.-
S., Zaid, Y., Rakotoarivelo, V., et al. High levels of eicosanoids and docosanoids in the lungs of intubated COVID- 19 patients. FASEB J. 35(6), e21666 (2021). Hartling, I., Cremonesi, A., Osuna, E., et al. Quantitative profiling of inflammatory and pro-
resolving lipid mediators in human adolescents and mouse plasma using UHPLC- MS/MS. Clin. Chem. Lab. Med. 59(11), 1811-1823 (2021). Archambault, A.-
S., Turcotte, C., Martin, C., et al. Comparison of eight 15- lipoxygenase (LO) inhibitors on the biosynthesis of 15- LO metabolites by human neutrophils and eosinophils. PLoS One 13(8), e0202424 (2018).
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