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SB-431542 是 TGF-β1 受体 ALK5 的强效选择性抑制剂（IC50 = 94 nM）1。3 SB-431542 可特异性阻断 Smad 信号传导，减少纤维化和癌症相关基因的表达。3 通过对 ALK/Smad 信号传导的影响，SB-431542 可抑制胚胎干细胞和诱导多能干细胞的更新并促进其分化。
Formal Name
4-
[4- (1,3- benzodioxol- 5- yl)- 5- (2- pyridinyl)- 1H- imidazol- 2- yl]- benzamide, hydrate Molecular Formula
C22H16N4O3 • XH2O
Formula Weight
384.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 20 mg/ml
- DMSO: 20 mg/ml
- DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
- Ethanol: 2 mg/ml
λmax
329 nm
SMILES
NC(C(C=C1)=CC=C1C2=NC(C3=CC=C(OCO4)C4=C3)=C(C5=CC=CC=N5)N2)=O.O
InChi Code
InChI=1S/C22H16N4O3.H2O/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17;/h1-11H,12H2,(H2,23,27)(H,25,26);1H2
InChi Key
WQUIJVKNPYBZOF-UHFFFAOYSA-N
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产品组分
内容
型号
规格 储存温度
SB-431542水合物 13031-01 1mg -20°C SB-431542水合物 13031-02 5mg -20°C SB-431542水合物 13031-03 10mg -20°C SB-431542水合物 13031-04 25mg -20°C 操作手册
1 1 常温
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注意事项
保存建议 厂家推荐蓝冰运输。当您收到产品后，按照说明书建议保存于-20°C。 -
FAQ
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Product Description References
1. Callahan, J.F., Burgess, J.L., Fornwald, J.A., et al. Identification of novel inhibitors of the transforming growth factor ß1 (TGF-
ß1) type 1 receptor (ALK5). J. Med. Chem. 45(5), 999-1001 (2002). 2. Laping, N.J., Grygielko, E., Mathur, A., et al. Inhibition of Transforming Growth Factor (TGF)-
ß1- Induced Extracellular Matrix with a Novel Inhibitor of the TGF- ß Type I Receptor Kinase Activity: SB- 431542. Mol. Pharmacol. 62(1), 58-64 (2002). 3. Inman, G.J., Nicolás, F.J., Callahan, J.F., et al. SB-
431542 is a potent and specific inhibitor of transforming growth factor- β superfamily type I activin receptor- like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol. Pharmacol. 62(1), 65-74 (2002). 4. James, D., Levine, A.J., Besser, D., et al. TGFß/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells. Development 132, 1273-1282 (2005).
5. Chambers, S.M., Fasano, C.A., Papapetrou, E.P., et al. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat. Biotechnol. 27(3), 275-280 (2009).
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