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血栓素B2(TXB2)是 TXA2 的一种非酶促性、稳定、非活性代谢产物,具有高度不稳定性。尿液中 TXB2 的水平反映肾内 TXA2 的合成,而其代谢物 11-脱氢 TXB2(货号 19500)和 2,3-二羟 TXB2(型号 19510)则反映全身 TXA2 的分泌。
Formal Name
9α,11,15S-
trihydroxythromba- 5Z,13E- dien- 1- oic acid CAS Number
54397-85-2
Synonyms
- TXB2
Molecular Formula
C20H34O6
Formula Weight
370.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: >50 mg/ml
- DMSO: >25 mg/ml
- Ethanol: >100 mg/ml
- Methyl Acetate: 10 mg/ml
- PBS pH 7.2: >100 µg/ml
SMILES
O[C@@H]1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)OC(O)C1
InChi Code
InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1
InChi Key
XNRNNGPBEPRNAR-JQBLCGNGSA-N
关键词:- 血栓素B2
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产品组分
内容
型号
规格 储存温度
血栓素B2 19030-01 1mg -20°C 血栓素B2 19030-02 5mg -20°C 血栓素B2 19030-03 10mg -20°C 操作手册
1 1 常温
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注意事项
保存建议 厂家推荐蓝冰运输。当您收到产品后,按照说明书建议保存于-20°C。 -
FAQ

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Product Description References
1. Needleman, P., Moncada, S., Bunting, S., et al. Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides. Nature 261(5561), 558-560 (1976).
2. Patrono, C., Ciabattoni, G., Pugliese, F., et al. Estimated rate of thromboxane secretion into the circulation of normal humans. J. Clin. Invest. 77(2), 590-594 (1986).
3. Uyama, O., Matsumoto, M., Fujisawa, A., et al. Plasma concentrations of thromboxane B2 in patients with hypertension or cerebrovascular disease. Prostaglandins Med. 7(3), 199-207 (1981).
4. Arantes, F.B.B., Menezes, F.R., Franci, A., et al. Influence of direct thrombin inhibitor and low molecular weight heparin on platelet function in patients with coronary artery disease: A prospective interventional trial. Adv. Ther. 37(1), 420-430 (2020).
5. Ferroni, P., Riondino, S., Vazzana, N., et al. Biomarkers of platelet activation in acute coronary syndromes. Thromb. Haemost. 108(6), 1109-1123 (2012).
6. Patrono, C., Ciabattoni, G., Patrignani, P., et al. Evidence for a renal origin of urinary thromboxane B2 in health and disease. Adv. Prostaglandin Thromboxane Leukot. Res. 11, 493-498 (1983).
7. Lawson, J.A., Patrono, C., Ciabattoni, G., et al. Long-
lived enzymatic metabolites of thromboxane B2 in the human circulation. Anal. Biochem. 155(1), 198-205 (1986). Product Citations
Pang, Y., Liu, X., Zhao, C., et al. LC-
MS/MS- based arachidonic acid metabolomics in acute spinal cord injury reveals the upregulation of 5- LOX and COX- 2 products. Free Radic. Biol. Med. 193(Pt 1), 363-372 (2022). Archambault, A.-
S., Zaid, Y., Rakotoarivelo, V., et al. High levels of eicosanoids and docosanoids in the lungs of intubated COVID- 19 patients. FASEB J. 35(6), e21666 (2021). Roberts, L.M., Schwarz, B., Speranza, E., et al. Pulmonary infection induces persistent, pathogen-
specific lipidomic changes influencing trained immunity. iScience 24(9), 103025 (2021). Archambault, A.-
S., Zaid, Y., Rakotoarivelo, V., et al. Lipid storm within the lungs of severe COVID- 19 patients: Extensive levels of cyclooxygenase and lipoxygenase- derived inflammatory metabolites. medRxiv (2020). Meriwether, D., Sulaiman, D., Volpe, C., et al. Apolipoprotein A-
I mimetics mitigate intestinal inflammation in COX2- dependent inflammatory bowel disease model. J. Clin. Invest. 130, 3670-3685 (2019). Dalli, J., Colas, R.A., Walker, M.E., et al. Lipid Mediator Metabolomics via LC-
MS/MS Profiling and Analysis. Clinical Metabolomics 59-72 (2018). Sorgi, C.A., Peti, A.P.F., Petta, T., et al. Comprehensive high-
resolution multiple- reaction monitoring mass spectrometry for targeted eicosanoid assays. Sci. Data 5, 180167 (2018). Gouveia-
Figueira, S., Karlsson, J., Deplano, A., et al. Characterisation of (R)- 2- (2- fluorobiphenyl- 4- yl)- N- (3- methylpyridin- 2- yl)propanamide as a dual fatty acid amide hydrolase: Cyclooxygenase inhibitor. PLoS One 10(9), e0139212 (2015).
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