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花生四烯酸-d8 在 5、6、8、9、11、12、14 和 15 位上含有八个氘原子。它可用作气相色谱或液相色谱-质谱法量化花生四烯酸的内标。花生四烯酸是一种必需脂肪酸,也是所有前列腺素、血栓素和白三烯的前体。几乎所有的细胞花生四烯酸都酯化在膜磷脂中,其存在通过多种相互关联的途径受到严格调控1。受体刺激的游离花生四烯酸的释放、代谢和再摄取都是细胞信号传导和炎症的重要环节。
Formal Name
5Z,8Z,11Z,14Z-
eicosatetraenoic- 5,6,8,9,11,12,14,15- d8 acid CAS Number
69254-37-1
Synonyms
- AA-
d8
Molecular Formula
C20H24D8O2
Formula Weight
312.5
Purity
≥99% deuterated forms (d1-
d8) Formulation
A solution in methyl acetate
Solubility
- 0.1 M Na2CO3: 1.7 mg/ml
- DMF: >100 mg/ml
- DMSO: >100 mg/ml
- Ethanol: Miscible
SMILES
CCCCC/C([2H])=C([2H])\C/C([2H])=C([2H])\C/C([2H])=C([2H])\C/C([2H])=C([2H])\CCCC(O)=O
InChi Code
InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-,16-15-/i6D,7D,9D,10D,12D,13D,15D,16D
InChi Key
YZXBAPSDXZZRGB-FBFLGLDDSA-N
Side Chain Carbon Sum
20:4
关键词:- 花生四烯酸-d8
- AA-
-
产品组分
内容
型号
规格 储存温度
花生四烯酸-d8 390010-01 1mg -20°C 花生四烯酸-d8 390010-02 5mg -20°C 花生四烯酸-d8 390010-03 10mg -20°C 操作手册
1 1 常温
-
注意事项
保存建议 厂家推荐蓝冰运输。当您收到产品后,按照说明书建议保存于-20°C。 -
FAQ

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Product Description References
1. Burgoyne, R.D., and Morgan, A. The control of free arachidonic acid levels. Trends Biochem. Sci. 15(10), 365-366 (1990).
2. Nixon, A.B., Greene, D.G., and Wykle, R.L. Comparison of acceptor and donor substrates in the CoA-
independent transacylase reaction in human neutrophils. Biochim. Biophys. Acta 1300(3), 187-196 (1996). Product Citations
Archambault, A.-
S., Zaid, Y., Rakotoarivelo, V., et al. Lipid storm within the lungs of severe COVID- 19 patients: Extensive levels of cyclooxygenase and lipoxygenase- derived inflammatory metabolites. medRxiv (2020). Yan, B., Chu, H., Yang, D., et al. Characterization of the lipidomic profile of human coronavirus-
infected cells: Implications for lipid metabolism remodeling upon coronavirus replication. Viruses 11(1), 73 (2019). Shin, M., Buckner, A., Prince, J., et al. Diacylglycerol lipase-
b is required for TNF- a response but not CD8+ T cell priming capacity of dendritic cells. Cell Chem. Bio. 26, 1-6 (2019). Sorgi, C.A., Peti, A.P.F., Petta, T., et al. Comprehensive high-
resolution multiple- reaction monitoring mass spectrometry for targeted eicosanoid assays. Sci. Data 5, 180167 (2018). Lin, N., Shay, J.E.S., Xie, H., et al. Myeloid cell hypoxia-
inducible factors promote resolution of inflammation in experimental colitis. Front. Immunol. 9(2565), (2018). Ercan, S., Kencebay, C., Basaranlar, G., et al. Induction of omega 6 inflammatory pathway by sodium metabisulfite in rat liver and its attenuation by ghrelin. Lipids Health Dis. 14:7, (2015).
Jovanović, V., Aziz, N.A., Lim, Y.T., et al. Lipid anti-
lipid antibody responses correlate with disease activity in systemic lupus erythematosus. PLoS one 8(2), e55639 (2013). Rouzer, C.A., and Marnett, L.J. Glycerylprostaglandin synthesis by resident peritoneal macrophages in response to a zymosan stimulus. J. Biol. Chem. 280(29), 26690-26700 (2005).
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