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Rac1磁珠激活下拉(Pull-Down)试剂盒
Rho 开关通过在活跃的 GTP 结合态和不活跃的 GDP 结合态之间交替运行。 了解调控 GTP 酶激活/失活的机制显然具有重要的生物学意义,也是目前正在深入研究的课题。 许多 Rho 家族效应蛋白会特异性识别蛋白的 GTP 结合形式,这一事实已被实验利用,开发出一种强大的亲和纯化检测方法,用于监测 Rac 和 Cdc42 蛋白的活化。 该检测方法使用了 Cdc42 / Rac 效应蛋白 p21 活化激酶 1(PAK)的 Cdc42/Rac 交互结合(CRIB)区域(也称为 p21 结合域,PBD)。 事实证明,CRIB/PBD 蛋白基团能与 Rac 和/或 Cdc42 蛋白的 GTP 结合形式特异性结合。 事实上,PAK 的 PBD 区域对 GTP-Rac 和 GTP-Cdc42 都有很高的亲和力,而且 PAK 的结合会导致 Rac 和 Cdc42 的内在水解率和催化水解率显著降低,因此它是亲和纯化细胞裂解液中 GTP-Rac 和 GTP-Cdc42 的理想工具。 本试剂盒中的 PAK-PBD 蛋白对应于 67-150 个残基。 其中包括高度保守的 CRIB 区域(aa 74-88)以及与 GTP-Rac 和 GTP-Cdc42 高亲和力相互作用所需的序列。 PAK-PBD 以 GST 融合蛋白的形式存在,可以用谷胱甘肽亲和珠 "拉取 "PAK-PBD/GTP-Rac(或 GTP-Cdc42)复合物。 因此,该检测提供了一种量化细胞中 Rac 或 Cdc42 活化的简单方法。 活化的 Rac 量可通过使用 Rac 特异性抗体进行 Western 印迹来确定。
Rac1磁珠激活下拉(Pull-Down)试剂盒具有如下优势和特点:
- 分析体内 Rac1 激活水平。
- 检测能增强 Rac1 活性的化合物和蛋白质。
- 检测抑制 Rac1 活性的化合物和蛋白质
图 1. Cdc42磁珠激活Pull-Down试剂盒中的谷胱甘肽琼脂糖珠颜色鲜艳,使试剂盒易于使用。
图 2.通过用 GTPγS 或 GDP 加载细胞裂解液中的 Rac1 蛋白,对 Rac1 活化试验进行了测试。不出所料,GTPγS 负载的 Rac1 非常有效地沉淀下来,而 GDP 负载的 Rac1 则很少沉淀下来。
图 2. BK035-S Rac1 活化检测的结果。使用试剂盒 BK035-S 在 Western 印迹中沉淀并检测活化的 Rac1。第一条泳道显示的是 50 ng 重组 His 标记的 Rac1 标准品(重组 His-Rac1)。随后的泳道显示从等量细胞裂解液中拉取无活性的 GDP 负载 Rac1(Rac1-GDP PD)或活性的 GTPγS 负载 Rac1(Rac1-GTP PD)。
产品组分
内容 |
型号 |
规格 |
储存温度 |
Rac1磁珠激活下拉(Pull-Down)试剂盒 | CNBK035-01 | 20次 | 2-8°C |
Rac1磁珠激活下拉(Pull-Down)试剂盒 | CNBK035-02 | 50次 | 2-8°C |
操作手册 |
1 | 1 |
常温 |
注意事项
保存建议 | 厂家推荐蓝冰运输。当您收到产品后,按照说明书建议保存于-20°C。 |
FAQ
Author | Title | Journal | Year | Article Link |
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Morretton, Jean-Philippe et al. | A catalog of numerical centrosome defects in epithelial ovarian cancers | EMBO Molecular Medicine | 2022 | ISSN 1757--4684 |
Singh, Neeraj et al. | BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1 | Science Advances | 2022 | ISSN 2375-2548 |
Wang, Yuting et al. | EPS8L1 promotes migration and metastasis of ovarian cancer by activating Rac1/MAPK signaling pathway via upregulating TIAM2 | Authorea Preprints | 2022 | Article Link |
Adan, Hanad et al. | Activated Src requires Cadherin-11, Rac, and gp130 for Stat3 activation and survival of mouse Balb/c3T3 fibroblasts | Cancer Gene Therapy 2022 29:10 | 2022 | ISSN 1476--5500 |
Usuki, Seigo et al. | Konjac Ceramide (kCer)-Mediated Signal Transduction of the Sema3A Pathway Promotes HaCaT Keratinocyte Differentiation | Biology | 2022 | ISSN 2079-7737 |
Karthikeyan, Subbulakshmi et al. | RAB4A GTPase regulates epithelial-to-mesenchymal transition by modulating RAC1 activation | Breast Cancer Research | 2022 | ISSN 1465-542X |
Adan, H et al. | Activated Src requires Cadherin-11, Rac, and gp130 for Stat3 activation and survival of mouse Balb/c3T3 fibroblasts | Cancer Gene … | 2022 | Article Link |
Khan, Alamzeb et al. | ArhGEF12 activates Rap1A and not RhoA in human dermal microvascular endothelial cells to reduce tumor necrosis factor-induced leak | FASEB journal : official publication of the Federation of American Societies for Experimental Biology | 2022 | ISSN 1530-6860 |
Masi, Ilenia et al. | Endothelin-1 drives invadopodia and interaction with mesothelial cells through ILK | Cell Reports | 2021 | ISSN 2211-1247 |
Wang, Junyi et al. | Rho-GEF Trio regulates osteosarcoma progression and osteogenic differentiation through Rac1 and RhoA | Cell Death and Disease | 2021 | ISSN 2041-4889 |
Guo, Shuyu et al. | Trio cooperates with Myh9 to regulate neural crest-derived craniofacial development | Theranostics | 2021 | ISSN 1838-7640 |
Wang, Jiang Lin et al. | Spinophilin modulates pain through suppressing dendritic spine morphogenesis via negative control of Rac1-ERK signaling in rat spinal dorsal horn | Neurobiology of Disease | 2021 | ISSN 1095-953X |
Zhou, Wenqing et al. | Mitofusin 2 regulates neutrophil adhesive migration and the actin cytoskeleton | Journal of Cell Science | 2021 | ISSN 1477-9137 |
Bai, Xiaoyuan et al. | Induction of cyclophilin A by influenza A virus infection facilitates group A Streptococcus coinfection | Cell Reports | 2021 | ISSN 2211-1247 |
Li, Chunsen et al. | GEFT Inhibits Autophagy and Apoptosis in Rhabdomyosarcoma via Activation of the Rac1/Cdc42-mTOR Signaling Pathway | Frontiers in Oncology | 2021 | ISSN 2234-943X |
Agbaegbu Iweka, Chinyere et al. | The lipid phosphatase-like protein PLPPR1 associates with RhoGDI1 to modulate RhoA activation in response to axon growth inhibitory molecules | Journal of Neurochemistry | 2021 | ISSN 1471-4159 |
Floerchinger, Alessia et al. | Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging | Cell Reports | 2021 | ISSN 2211-1247 |
McCray, Brett A. et al. | Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension | Nature Communications | 2021 | ISSN 2041-1723 |
Romano, Roberta et al. | Alteration of the late endocytic pathway in Charcot–Marie–Tooth type 2B disease | Cellular and Molecular Life Sciences | 2021 | ISSN 1420-9071 |
Barabutis, Nektarios et al. | Protective mechanism of the selective vasopressin V1A receptor agonist selepressin against endothelial barrier dysfunction | Journal of Pharmacology and Experimental Therapeutics | 2020 | ISSN 1521-0103 |
Fulmer, Diana et al. | Desert hedgehog-primary cilia cross talk shapes mitral valve tissue by organizing smooth muscle actin | Developmental Biology | 2020 | ISSN 1095-564X |
Wei, Yiju et al. | NEDD 4L‐mediated Merlin ubiquitination facilitates Hippo pathway activation | EMBO reports | 2020 | ISSN 1469--221X |
Danelon, Victor et al. | Modular and Distinct Plexin-A4/FARP2/Rac1 Signaling Controls Dendrite Morphogenesis | Journal of Neuroscience | 2020 | ISSN 1529-2401 |
Aladowicz, Ewa et al. | Shcd binds dock4, promotes ameboid motility and metastasis dissemination, predicting poor prognosis in melanoma | Cancers | 2020 | ISSN 2072-6694 |
Won, So Yeon et al. | Fibulin 5, a human Wharton's jelly-derived mesenchymal stem cells-secreted paracrine factor, attenuates peripheral nervous system myelination defects through the Integrin-RAC1 signaling axis | Stem Cells | 2020 | ISSN 1549-4918 |
Wang, Ruixiao et al. | Rac1 silencing, NSC23766 and EHT1864 reduce growth and actin organization of bladder smooth muscle cells | Life Sciences | 2020 | ISSN 1879-0631 |
Moody, Jasmine C. et al. | The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells | Nature Communications | 2020 | ISSN 2041-1723 |
Smalley, Tracess et al. | The Atypical Protein Kinase C Small Molecule Inhibitor ζ-Stat, and Its Effects on Invasion Through Decreases in PKC-ζ Protein Expression | Frontiers in Oncology | 2020 | ISSN 2234-943X |
Shin, Seung Kak et al. | Exogenous 8-hydroxydeoxyguanosine ameliorates liver fibrosis through the inhibition of Rac1-NADPH oxidase signaling | Journal of gastroenterology and hepatology | 2020 | ISSN 1440--1746 |
Benz, Peter M. et al. | AKAP12 deficiency impairs VEGF-induced endothelial cell migration and sprouting | Acta physiologica (Oxford, England) | 2020 | ISSN 1748--1716 |
Li, Zean et al. | The metastatic promoter DEPDC1B induces epithelial‐mesenchymal transition and promotes prostate cancer cell proliferation via Rac1‐PAK1 signaling | Clinical and Translational Medicine | 2020 | ISSN 2001--1326 |
Joshi, Rakesh et al. | DLC1 SAM domain-binding peptides inhibit cancer cell growth and migration by inactivating RhoA | Journal of Biological Chemistry | 2020 | ISSN 1083-351X |
Chen, Lixia et al. | CSRP2 suppresses colorectal cancer progression via p130Cas/Rac1 axis-meditated ERK, PAK, and HIPPO signaling pathways | Theranostics | 2020 | ISSN 1838-7640 |
Larribère, Lionel et al. | NF1-RAC1 axis regulates migration of the melanocytic lineage | Translational Oncology | 2020 | ISSN 1936-5233 |
Lian, Eric Y. et al. | RET isoforms contribute differentially to invasive processes in pancreatic ductal adenocarcinoma | Oncogene | 2020 | ISSN 1476-5594 |
Thamilselvan, Vijayalakshmi et al. | P-Rex1 Mediates Glucose-Stimulated Rac1 Activation and Insulin Secretion in Pancreatic β-Cells | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2020 | ISSN 1421--9778 |
Ichikawa, Takehiko et al. | Non-junctional role of Cadherin3 in cell migration and contact inhibition of locomotion via domain-dependent, opposing regulation of Rac1 | Scientific Reports | 2020 | ISSN 2045-2322 |
Yu, Qingfeng et al. | A NAV2729-sensitive mechanism promotes adrenergic smooth muscle contraction and growth of stromal cells in the human prostate | Journal of Biological Chemistry | 2019 | ISSN 1083-351X |
Liu, Chunxia et al. | Epigenetically upregulated GEFT-derived invasion and metastasis of rhabdomyosarcoma via epithelial mesenchymal transition promoted by the Rac1/Cdc42-PAK signalling pathway | EBioMedicine | 2019 | ISSN 2352-3964 |
Park, Jin Seok et al. | Switch-like enhancement of epithelial-mesenchymal transition by YAP through feedback regulation of WT1 and Rho-family GTPases | Nature Communications | 2019 | ISSN 2041-1723 |
Tsygankova, Oxana M. et al. | A unique role for clathrin light chain A in cell spreading and migration | Journal of Cell Science | 2019 | ISSN 1477-9137 |
Lang, Yue et al. | MiR-30 family prevents uPAR-ITGB3 signaling activation through calcineurin-NFATC pathway to protect podocytes | Cell Death and Disease | 2019 | ISSN 2041-4889 |
Dagliyan, Onur et al. | Engineering proteins for allosteric control by light or ligands | Nature Protocols | 2019 | ISSN 1750-2799 |
Zhou, Yi Fan et al. | Sema3E/PlexinD1 signaling inhibits postischemic angiogenesis by regulating endothelial DLL4 and filopodia formation in a rat model of ischemic stroke | FASEB Journal | 2019 | ISSN 1530-6860 |
Wong, Bin Sheng et al. | A direct podocalyxin–dynamin-2 interaction regulates cytoskeletal dynamics to promote migration and metastasis in pancreatic cancer cells | Cancer Research | 2019 | ISSN 1538-7445 |
Amato, Clelia et al. | WASP Restricts Active Rac to Maintain Cells’ Front-Rear Polarization | Current Biology | 2019 | ISSN 0960-9822 |
Herlemann, Annika et al. | Inhibition of smooth muscle contraction and ARF6 activity by the inhibitor for cytohesin GEFs, secinH3, in the human prostate | American Journal of Physiology - Renal Physiology | 2018 | ISSN 1522-1466 |
Wu, Yuqing et al. | Mycobacterial infection is promoted by neutral sphingomyelinase 2 regulating a signaling cascade leading to activation of β1-integrin | Cellular Physiology and Biochemistry | 2018 | ISSN 1421-9778 |
Zago, Giulia et al. | Ralb directly triggers invasion downstream ras by mobilizing the wave complex | eLife | 2018 | ISSN 2050-084X |
Barabutis, Nektarios et al. | Wild-type p53 enhances endothelial barrier function by mediating RAC1 signalling and RhoA inhibition | Journal of Cellular and Molecular Medicine | 2018 | ISSN 1582-1838 |
Hayashi, Kentaro et al. | Intracellular calcium signal at the leading edge regulates mesodermal sheet migration during Xenopus gastrulation | Scientific Reports | 2018 | ISSN 2045-2322 |
Shang, Wanjing et al. | Genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activation | Proceedings of the National Academy of Sciences of the United States of America | 2018 | ISSN 1091-6490 |
Liu, Yunlong et al. | Social Isolation Induces Rac1-Dependent Forgetting of Social Memory | Cell Reports | 2018 | ISSN 2211-1247 |
Hayes, Madeline N. et al. | Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma | Cell Stem Cell | 2018 | ISSN 1875-9777 |
McQueeney, Kelley E. et al. | Targeting ovarian cancer and endothelium with an allosteric PTP4A3 phosphatase inhibitor | Oncotarget | 2018 | ISSN 1949-2553 |
Shi, Hao et al. | Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R-STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity | Immunity | 2018 | ISSN 1097-4180 |
Yang, Huan et al. | Cytotoxic Necrotizing Factor 1 Downregulates CD36 Transcription in Macrophages to Induce Inflammation During Acute Urinary Tract Infections | Frontiers in Immunology | 2018 | ISSN 1664-3224 |
Tarr, Joseph T. et al. | The pivotal role of CCN2 in mammalian palatogenesis | Journal of Cell Communication and Signaling | 2017 | ISSN 1873-961X |
Yao, Zhihui et al. | P311 Accelerates Skin Wound Reepithelialization by Promoting Epidermal Stem Cell Migration Through RhoA and Rac1 Activation | Stem Cells and Development | 2017 | ISSN 1557-8534 |
Guo, Yaxiu et al. | Cytotoxic necrotizing factor 1 promotes prostate cancer progression through activating the Cdc42–PAK1 axis | Journal of Pathology | 2017 | ISSN 1096-9896 |
Gao, Jie et al. | The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning | eLife | 2017 | ISSN 2050-084X |
Margiotta, Azzurra et al. | Rab7a regulates cell migration through Rac1 and vimentin | Biochimica et Biophysica Acta - Molecular Cell Research | 2017 | ISSN 1879-2596 |
Tormos, Ana M. et al. | P38α regulates actin cytoskeleton and cytokinesis in hepatocytes during development and aging | PLoS ONE | 2017 | ISSN 1932-6203 |
Zhan, Rixing et al. | Nitric oxide promotes epidermal stem cell migration via cGMP-Rho GTPase signalling | Scientific Reports | 2016 | ISSN 2045-2322 |
Han, Jie et al. | Farnesyl pyrophosphate synthase inhibitor, ibandronate, improves endothelial function in spontaneously hypertensive rats | Molecular Medicine Reports | 2016 | ISSN 1791-3004 |
Tie, S. R. et al. | Regulation of sarcoma cell migration, invasion and invadopodia formation by AFAP1L1 through a phosphotyrosine-dependent pathway | Oncogene | 2016 | ISSN 1476-5594 |
Wang, Yan et al. | Involvement of Rac1 signalling pathway in the development and maintenance of acute inflammatory pain induced by bee venom injection | British Journal of Pharmacology | 2016 | ISSN 1476-5381 |
Wang, Y. et al. | Inhibition of prostate smooth muscle contraction and prostate stromal cell growth by the inhibitors of Rac, NSC23766 and EHT1864 | British Journal of Pharmacology | 2015 | ISSN 1476-5381 |
Wang, Shi Jie et al. | CD147 promotes Src-dependent activation of Rac1 signaling through STAT3/DOCK8 during the motility of hepatocellular carcinoma cells | Oncotarget | 2015 | ISSN 1949-2553 |
Zhan, Rixing et al. | Nitric oxide enhances keratinocyte cell migration by regulating Rho GTPase via cGMP-PKG signalling | PLoS ONE | 2015 | ISSN 1932-6203 |
Tang, Xiaoyun et al. | Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in mice | Journal of Lipid Research | 2014 | ISSN 1539-7262 |
Hara, Yusuke et al. | Directional migration of leading-edge mesoderm generates physical forces: Implication in Xenopus notochord formation during gastrulation | Developmental Biology | 2013 | ISSN 1095-564X |
Zallocchi, Marisa et al. | α1β1 Integrin/rac1-dependent mesangial invasion of glomerular capillaries in alport syndrome | American Journal of Pathology | 2013 | ISSN 0002-9440 |
Geletu, M. et al. | Classical cadherins control survival through the gp130/Stat3 axis | Biochimica et Biophysica Acta - Molecular Cell Research | 2013 | ISSN 0167-4889 |
Han, Gangwen et al. | Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositis | Nature Medicine | 2013 | ISSN 1078-8956 |
Lee, Wonhwa et al. | Barrier protective effects of withaferin A in HMGB1-induced inflammatory responses in both cellular and animal models | Toxicology and applied pharmacology | 2012 | ISSN 1096--0333 |
Nithipatikom, Kasem et al. | Cannabinoid receptor type 1 (CB1) activation inhibits small GTPase RhoA activity and regulates motility of prostate carcinoma cells | Endocrinology | 2012 | ISSN 1945--7170 |
Ninkovi, Jana et al. | Morphine decreases bacterial phagocytosis by inhibiting actin polymerization through cAMP-, Rac-1-, and p38 MAPK-dependent mechanisms | American Journal of Pathology | 2012 | ISSN 0002-9440 |
Wong, Hon Kit et al. | Merlin/NF2 regulates angiogenesis in schwannomas through a Rac1/semaphorin 3F-dependent mechanism | Neoplasia | 2012 | ISSN 1476-5586 |
Syed, Ismail et al. | L-threo-C 6 -pyridinium-ceramide bromide, a novel cationic ceramide, induces NADPH oxidase activation, mitochondrial dysfunction and loss in cell viability in INS 832/13 β-cells | Cellular Physiology and Biochemistry | 2012 | ISSN 1421-9778 |
Gastonguay, Adam et al. | The role of Rac1 in the regulation of NF-kB activity, cell proliferation, and cell migration in non-small cell lung carcinoma | Cancer Biology & Therapy | 2012 | ISSN 1538--4047 |
Jayaram, Bhavaani et al. | Isoprenylcysteine carboxyl methyltransferase facilitates glucose-induced Rac1 activation, ROS generation and insulin secretion in INS 832/13 β-cells | Islets | 2011 | ISSN 1938-2014 |
Souma, Tomokazu et al. | Luminal alkalinization attenuates proteinuria-induced oxidative damage in proximal tubular cells | Journal of the American Society of Nephrology | 2011 | ISSN 1046-6673 |
Vidal-Quadras, Maite et al. | Rac1 and Calmodulin Interactions Modulate Dynamics of ARF6-Dependent Endocytosis | Traffic | 2011 | ISSN 1398-9219 |
Balanis, Nikolas et al. | β3 integrin-EGF receptor cross-talk activates p190RhoGAP in mouse mammary gland epithelial cells | Molecular Biology of the Cell | 2011 | ISSN 1059-1524 |
Garkavtsev, Igor et al. | Dehydro-α-lapachone, a plant product with antivascular activity | Proceedings of the National Academy of Sciences of the United States of America | 2011 | ISSN 0027-8424 |
McAuley, Erin M. et al. | Phenylboronic acid is a more potent inhibitor than boric acid of key signaling networks involved in cancer cell migration | Cell Adhesion and Migration | 2011 | ISSN 1933-6926 |
Ock, Chan Young et al. | A novel approach for stress-induced gastritis based on paradoxical anti-oxidative and anti-inflammatory action of exogenous 8-hydroxydeoxyguanosine | Biochemical pharmacology | 2011 | ISSN 1873--2968 |
Skalski, Michael et al. | SNARE-mediated membrane traffic is required for focal adhesion kinase signaling and Src-regulated focal adhesion turnover | Biochimica et Biophysica Acta - Molecular Cell Research | 2011 | ISSN 0167-4889 |
Kobayashi, Takashi et al. | Activation of Rac1 is closely related to androgen-independent cell proliferation of prostate cancer cells both in vitro and in vivo | Molecular Endocrinology | 2010 | ISSN 0888-8809 |
Medhora, Meetha et al. | 20-HETE increases superoxide production and activates NAPDH oxidase in pulmonary artery endothelial cells | American Journal of Physiology - Lung Cellular and Molecular Physiology | 2008 | ISSN 1040-0605 |
Bergstrom, R. A. et al. | Agrin induced morphological and structural changes in growth cones of cultured hippocampal neurons | Neuroscience | 2007 | ISSN 0306-4522 |
Wang, Guoyan et al. | Genetic ablation of Rac1 in cartilage results in chondrodysplasia | Developmental Biology | 2007 | ISSN 0012-1606 |
Slice, Lee W. et al. | Angiotensin II and epidermal growth factor induce cyclooxygenase-2 expression in intestinal epithelial cells through small GTPases using distinct signaling pathways | The Journal of biological chemistry | 2005 | ISSN 0021--9258 |
Vogl, Thomas et al. | MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes | Blood | 2004 | ISSN 0006-4971 |
Sasai, Noriaki et al. | The neurotrophin-receptor-related protein NRH1 is essential for convergent extension movements | 2004 | PMID 15258592 | |
Yang, Seun Ah et al. | Rho and Rho-kinase mediate thrombin-induced phosphatidylinositol 4-phosphate 5-kinase trafficking in platelets | Journal of Biological Chemistry | 2004 | ISSN 0021-9258 |
Zhang, Yongjun et al. | Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival | The Journal of biological chemistry | 2004 | ISSN 0021--9258 |
Chromy, Brett A. et al. | Self-assembly of Abeta(1-42) into globular neurotoxins | Biochemistry | 2003 | ISSN 0006--2960 |
Quadri, Sadiqa K. et al. | Endothelial Barrier Strengthening by Activation of Focal Adhesion Kinase * | Journal of Biological Chemistry | 2003 | ISSN 0021--9258 |
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