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PLAT 又称 tPA。该基因编码组织型纤溶酶原激活剂，它是一种分泌型丝氨酸蛋白酶，可将纤溶酶原转化为纤溶酶。组织型纤溶酶原激活物合成为单链，被纤溶酶裂解为双链二硫键蛋白。这种酶在细胞迁移和组织重塑中发挥作用。酶活性增加会导致纤溶亢进，表现为出血过多；酶活性降低会导致纤溶不足，从而导致血栓形成或栓塞。该基因的交替剪接会产生多种转录本变体，编码不同的异构体。
Applications
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution
Western Blot: 0.1-0.5ug/ml, the detection limit is ~0.1ng/lane under reducing conditions. Optimal dilutions to be determined by the researcher.
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Immunogen
Recombinant protein corresponding to human TPA expressed in E. coli. (Position: H366-P562). Species sequence homology: mouse (83%) and rat (84%)
Form
Supplied as a lyophilized powder from PBS, 5% BSA, 0.05% sodium azide. Reconstitute with 200ul sterile dH2O.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human TPA. Species Crossreactivity: mouse
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
P00750
Isotype
IgG
Grade
Affinity Purified
Applications
WB
Crossreactivity
Hu Mo
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产品组分
内容
型号
规格 储存温度
兔抗TPA多克隆抗体 303678 100ug -20°C 操作手册
1 1 常温
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营销中心
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注意事项
保存建议 厂家推荐蓝冰运输。当您收到产品后，按照说明书建议保存于-20°C。 -
FAQ
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1. Marsh EB, et al. Serum creatinine may indicate risk of symptomatic intracranial hemorrhage after intravenous tissue plasminogen activator (IV tPA). Medicine (Baltimore), 2013 Nov. 2. Valle-Garay E, et al. tPA Alu (I/D) polymorphism associates with bacterial osteomyelitis. J Infect Dis, 2013 Jul 15.
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