苯赖加压素

苯赖加压素，Felypressin，是一种非儿茶酚胺血管收缩剂和加压素1激动剂。更多视频请关注视频号【艾维缔】。哔哩哔哩【IVDSHOW】。抖音【军哥聊表观】。

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苯赖加压素

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抑制剂

目录号

V30113

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体外研究 (In Vitro)	Felypressin 是一种源自垂体后叶的合成激素，由于其血管收缩特性而常用于牙科手术。 Felypressin 对血管平滑肌细胞的血管收缩作用似乎是由 V1 受体介导的 [1]。
体内研究 (In Vivo)	进行牙科治疗时，Felypressin 可减轻毒性。对于患有高血压的患者，苯加压素会升高舒张压[1]。 Wistar 大鼠用于测试苯加压素（240 ng/kg；腹膜内注射）的心血管作用。 Felypressin具有升高血压的作用。基于后区和中枢 V1 受体，苯加压素在心动过缓和平均动脉压变化之间提供了强有力的联系。 Felypressin 依赖于 V1 受体来引起升压和心动过缓作用 [2]。
参考文献	[1]. Felypressin increases blood pressure during dental procedures in hypertensive patients. Arq Bras Cardiol. 2012 Aug;99(2):724-31. [2]. Cardiovascular effects of felypressin. Anesth Prog. 2006 Winter;53(4):119-25.
其他信息	Felypressin is a synthetic nonapeptide comprising cysteinyl, phenylalanyl, phenylalanyl, glutaminyl, asparaginyl, cysteinyl, prolyl, lysyl, and glycinamide residues in sequence, with a disulfide bridge joining the two cysteine residues. Its antidiuretic effects are less than those of vasopressin. It is used as a vasoconstrictor in local anaesthetic injections for dental use, and is an ingredient of preparations that have been used for treatment of pain and inflammation of the mouth. It has a role as a vasoconstrictor agent and a vasopressin receptor agonist. A synthetic nonapeptide comprising cysteinyl, phenylalanyl, phenylalanyl, glutaminyl, asparaginyl, cysteinyl, prolyl, lysyl, and glycinamide residues in sequence, with a disulfide bridge joining the two cysteine residues. Its antidiuretic effects are less than those of vasopressin. It is a non-catecholamine vasoconstrictor used in local anaesthetic injections for dental use, and is an ingredient of preparations that have been used for treatment of pain and inflammation of the mouth. A synthetic analog of LYPRESSIN with a PHENYLALANINE substitution at residue 2. Felypressin is a vasoconstrictor with reduced antidiuretic activity. Drug Indication For use as an alternative to adrenaline as a localising agent, provided that local ischaemia is not essential. Mechanism of Action Felypressin binds to the vasopressin receptor V1a. This causes contraction of the smooth muscle in the vascular bed, especially capillaries, small arterioles and venules.

*注: 文献方法仅供参考, IVDSHOW并未独立验证这些方法的准确性。

分子式	C46H65N13O11S2
分子量	1040.2188
精确质量	1039.436
CAS号	56-59-7
相关CAS号	Felypressin acetate;914453-97-7
PubChem CID	14257662
外观&性状	White to off-white solid powder
密度	1.3±0.1 g/cm3
沸点	1571.3±65.0 °C at 760 mmHg
熔点	254-257 °C
闪点	904.1±34.3 °C
蒸汽压	0.0±0.3 mmHg at 25°C
折射率	1.574
LogP	-5
tPSA	455.92
氢键供体(HBD)数目	12
氢键受体(HBA)数目	15
可旋转键数目(RBC)	19
重原子数目	72
分子复杂度/Complexity	1920
定义原子立体中心数目	8
SMILES	C1C[C@H](N(C1)C(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=CC=C4)N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N
InChi Key	SFKQVVDKFKYTNA-DZCXQCEKSA-N
InChi Code	InChI=1S/C46H65N13O11S2/c47-18-8-7-14-29(40(64)52-23-38(51)62)54-45(69)35-15-9-19-59(35)46(70)34-25-72-71-24-28(48)39(63)55-31(20-26-10-3-1-4-11-26)43(67)56-32(21-27-12-5-2-6-13-27)42(66)53-30(16-17-36(49)60)41(65)57-33(22-37(50)61)44(68)58-34/h1-6,10-13,28-35H,7-9,14-25,47-48H2,(H2,49,60)(H2,50,61)(H2,51,62)(H,52,64)(H,53,66)(H,54,69)(H,55,63)(H,56,67)(H,57,65)(H,58,68)/t28-,29-,30-,31-,32-,33-,34-,35-/m0/s1
化学名	(2S)-N-[(2S)-6-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxohexan-2-yl]-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13,16-dibenzyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide
HS Tariff Code	2934.99.9001
存储方式	Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month 注意：请将本产品存放在密封且受保护的环境中，避免吸湿/受潮。
运输条件	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

产品组分

内容	型号	规格	储存温度
苯赖加压素	V30113-01	5mg	-20°C
苯赖加压素	V30113-02	10mg	-20°C
苯赖加压素	V30113-03	50mg	-20°C
苯赖加压素	V30113-04	100mg	-20°C
操作手册	1	1	常温

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FAQ
[1]. Felypressin increases blood pressure during dental procedures in hypertensive patients. Arq Bras Cardiol. 2012 Aug;99(2):724-31.

[2]. Cardiovascular effects of felypressin. Anesth Prog. 2006 Winter;53(4):119-25.