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AZD2281,又称奥拉帕利,是一种聚(ADP - 核糖)聚合酶1(PARP1)抑制剂,也是一种正在携带BRCA1或BRCA2基因突变患者中进行试验的抗癌药物。
Purity
≥99% by HPLC
Format
White to off-white crystalline solid; granular or powder.
Formula
C24H23FN4O3
MW
434.46 Da
Solubility
Soluble in DMSO at 33 mg/ml; soluble in ethanol at 1.7 mg/ml with slight warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM buffers, serum, or other additives may increase or decrease the aqueous solubility.
Biological Activity
Olaparib (AZD2281) is a potent PARP inhibitor with IC50 of 1.1 nM for PARP1 using the BPS Bioscience PARP1 Assay Kit (Cat. # 80551). It inhibits PARP2 with IC50 = 0.9 nM for using the PARP2 Assay Kit (Cat. # 80552).
CAS Registry #
763113-22-0
关键词:- AZD2281(奥拉帕里布)
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产品组分
内容
型号
规格 储存温度
AZD2281(奥拉帕里布)
27003-01 250mg
-20°C AZD2281(奥拉帕里布)
27003-02 500mg
-20°C 操作手册
1 1 常温
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注意事项
保存建议 厂家推荐蓝冰运输。当您收到产品后,按照说明书建议保存于-20°C。 -
FAQ

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References
1. De Murcia, J., et al., Proc. Natl. Acad. Sci. USA 94: 7303 – 7307 (1997)
2. Bryant, H.E., et al., Nature 434: 913 – 915 (2005)
3. Farmer, H., et al., Nature 434: 917 – 921 (2005)Evaluating Bis-Phenacyl Bromide-Based Bis-Heterocyclic Templates as Anticancer Prototypes and Potential PARP1 Inhibitors.
Refaie M Kassab, Mohamed A M Ali, ..., Alyaa S Abdel Halim
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Alejandro Rubiales-Martínez, Joel Martínez, ..., María Inés Nicolás-Vázquez
International journal of molecular science… | 2024 Jan 24 | 38255943
In Vitro and Computational Studies of Perezone and Perezone Angelate as Potential Anti-Glioblastoma Multiforme Agents
Maricarmen Hernández-Rodríguez, Pablo I. Mendoza Sánchez, ..., Luca Aquilito
Molecules | 2022 Feb 26 | 35268667
Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology
Tanima SenGupta, Konstantinos Palikaras, ..., Hilde Nilsen
Cell reports | 2021 Sep 07 | 34496255
Roles for APRIN (PDS5B) in homologous recombination and in ovarian cancer prediction
Anthony M. Couturier, Hubert Fleury, ..., Jean-Yves Masson
Nucleic Acids Research | 2016 Dec 15 | 27924011
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