His标签KDM5D蛋白

His标签KDM5D蛋白，KDM5D Protein (His tag)，非常适用于酶动力学研究、抑制剂筛选和选择性分析。更多视频请关注视频号【艾维缔】。哔哩哔哩【IVDSHOW】。抖音【军哥聊表观】。

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His标签KDM5D蛋白

所属分类

重组蛋白

目录号

ABIN1589770

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TargetSee all KDM5D Proteins

KDM5D (Lysine (K)-Specific Demethylase 5D (KDM5D))

Protein Type

Recombinant

Origin

Human

Source

Escherichia coli (E. coli)

Purification tag / Conjugate

This KDM5D protein is labelled with His tag.

Sequence

ALLVALQRLP VRLPEGEALQ CLTERAIGWQ DRARKALASE DVTALLRQLA ELRQQLQAKP RPEEASVYTS ATACDPIREG SGNNISKVQG LLENGDSVTS PENMAPGKGS DLELLSSLLP QLTGPVLELP EAIRAPLEEL MMEGDLLEVT LDENHSIWQL LQAGQPPDLD RIRTLLELEK FEHQGSRTRS RALERRRRRQ KVDQGRNVEN LVQQELQSKR ARSSGIMSQV GREEEHYQEK ADRENMFLTP STDHSPFLKG NQNSLQHKDS GSSAACPSLM PLLQLSYSDE QQLLEHHHHH H

Characteristics

Length (AA): 301
Chromosomal location: Yq11, Yq11

Purity

> 95 % by SDS-PAGE. Visualized by silver stain

Format

Lyophilized

Reconstitution

The lyophilized human SMCY is supplied in lyophilized form and can be reconstituted in PBS or water. This solution can be diluted into other buffered solutions or stored frozen for future use.

Buffer

50 mM NaP, 300 mM NaCl, pH 8.0

Target

KDM5D (Lysine (K)-Specific Demethylase 5D (KDM5D))

Alternative Name

SMCY/JARID1D (KDM5D Products)

Background

H-Y antigen is defined as a male histocompatibility antigen that causes rejection of male skin grafts by female recipients of the same inbred strain of rodents. Male-specific, or H-Y antigen(s), are also detected by cytotoxic T cells and antibodies. H-Y antigen appears to be an integral part of the membrane of most male cells. In addition, H-Y antibodies detect a soluble form of H-Y that is secreted by the testis. The gene (Smcy/SMCY) coding for H-Y antigen detected by T cells has been cloned. It is expressed ubiquitously in male mice and humans, and encodes an epitope that triggers a specific T-cell response in vitro. Additional epitopes coded for by different Y-chromosomal genes are probably required in vivo for the rejection of male grafts by female hosts. The molecular nature of H-Y antigen detected by antibodies on most male cells is not yet known. Testis-secreted, soluble H-Y antigen, however, was found to be identical to Müllerian-inhibiting substance (MIS). MIS cross-reacts with H-Y antibodies and identical findings were obtained for soluble H-Y antigen and MIS, i.e., secretion by testicular Sertoli and, to a lesser degree, ovarian cells, binding to a gonad-specific receptor, induction of gonadal sex reversal in vitro and, in cattle, in vivo. H-Y antisera also detect a molecule or molecules associated with the heterogametic sex in non-mammalian vertebrates. Molecular data on this antigen or antigens are not yet available.
Synonyms: KDM5D lysine (K)-specific demethylase 5D, HY, HYA

Molecular Weight

33.87 kDa

NCBI Accession

NM_001146705, NP_001140177

UniProt

Q9BY66

Pathways

Warburg Effect
关键词:
- His标签KDM5D蛋白