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Predicted Species Reactivity Homo sapiens|Human Product Format Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose. Host E.coli Conjugation Unconjugated Application Ctrl (+), SDS-PAGE, WB Additional Information Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
Residues: Gln21-Asn349
Isoelectric Point: 6.0
Subcellular Location: Nucleus, cytoplasmReconstitution and Storage 2°C to 8°C|-80°C Concentration 100 ug/mL (prior to lyoph) Purity > 90% Source E.coli Tag N-terminal His Tag Gene Symbol HIF1AN Gene Full Name hypoxia inducible factor 1 subunit alpha inhibitor Alias Symbols factor inhibiting HIF1;factor inhibiting HIF-1;FIH1;FIH-1;hypoxia inducible factor 1 alpha subunit inhibitor;hypoxia-inducible factor 1-alpha inhibitor;hypoxia-inducible factor asparagine hydroxylase;peptide-aspartate beta-dioxygenase. NCBI Gene Id 55662 Protein Name Hypoxia-inducible factor 1-alpha inhibitor Description of Target Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation. Uniprot ID Q9NWT6 Protein Accession # NP_060372.2 Nucleotide Accession # NM_017902.2 Protein Size (# AA) Gln31~Asn349 Molecular Weight 41/44kDa -
产品组分
内容 型号
规格 储存温度
HIF1AN重组蛋白
OPCD03872-01 10ug
-80°C HIF1AN重组蛋白
OPCD03872-02 50ug
-80°C HIF1AN重组蛋白
OPCD03872-03 200ug
-80°C 操作手册
1 1 常温
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注意事项
保存建议 厂家推荐蓝冰运输。当您收到产品后，按照说明书建议保存于-20°C。 -
FAQ
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Yamane K 等人 （2007） Mol Cell 25：801-812
Barrett A et al. （2007） Int J Cancer 121：265-275
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