- 产品描述
- 产品组分
- 文件资源
- 营销中心
- 注意事项
- FAQ
- 文献追踪
-
在活化的RAS刺激后，B-raf会磷酸化MEK1，从而激活丝裂原活化蛋白（MAP）激酶级联反应。由于MAPK级联反应已被证实是黑色素瘤发展过程中的关键因素，因此有人提出，靶向B-raf可能是一种很有前景的对抗黑色素瘤的方法。更重要的是，40%-60%的黑色素瘤会出现BRAF突变，例如B-Raf（V600E）突变，这会导致MAP激酶通路的持续激活。B-Raf（V600E）激酶检测试剂盒旨在通过使用Kinase-Glo® MAX作为检测试剂，测量B-Raf（V600E）激酶活性，以用于筛选和分析应用。此外，该B-Raf（V600E）激酶检测试剂盒还包含野生型B-Raf酶，作为研究人员研究B-Raf（V600E）特异性抑制剂时的阳性对照。
Assay Kit Format
Luminescent
Species
Human
Supplied As
The B-Raf(V600E) Kinase Assay Kit comes in a convenient 96-well format, with enough purified recombinant B-Raf enzyme, B-Raf substrate, ATP and kinase assay buffer for 100 enzyme reactions.
Target(s)
BRAF
UniProt #
P15056
-
产品组分
内容 型号
规格 储存温度
BRAF(V600E)激酶检测试剂盒
48688-01 96次
-20°C BRAF(V600E)激酶检测试剂盒
48688-02 192次
-20°C 操作手册
1 1 常温
-
营销中心
-
注意事项
保存建议 厂家推荐蓝冰运输。当您收到产品后，按照说明书建议保存于-20°C。 -
FAQ
-
References
Cantwell-Dorris, ER, et al. Mol Cancer Ther. 2011 Mar;10(3):385-94
Obaid NM, et al. Int J Mol Sci. 2017 Mar 8;18(3). pii: E585.
Untargeted Diversity-Oriented Synthesis for the Discovery of New Antitumor Agents: An Integrated Approach of Inverse Virtual Screening, Bioinformatics, and Omics for Target Deconvolution
Tania Ciaglia, Valeria Napolitano, ..., Alessia Bertamino
Journal of medicinal chemistry | 2025 Jul 24 | 40705771
Supplementary Novel 5,6-dichlorobenzimidazole derivatives as dual BRAFWT and BRAFV600E inhibitors: design, synthesis, anti-cancer activity and molecular dynamics simulations.
Ahmed Temirak, Ahmed M. El Kerdawy, ..., Heba T. Abdel-Mohsen
BMC Chemistry | 2025 Feb 21 | 39985108
Design, synthesis, and evaluation of new benzimidazole thiourea derivatives as antitumor agents.
Mohamed H Aboutaleb, Nadia S El-Gohary, ..., Mohamed M El-Kerdawy
Archiv der Pharmazie | 2023 Nov 03 | 37602810
Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAF V600E Protein
Elisabetta Marini, Marco Marino, ..., Xinyong Liu
Molecules | 2022 Dec 03 | 36500607
CB-RAF600E-1 exerts efficacy in vemurafenib-resistant and non-resistant-melanoma cells via dual inhibition of RAS/RAF/MEK/ERK and PI3K/Akt signaling pathways
Mesfer Al Shahrani, Prasanna Rajagopalan, Yasser Alraey
Saudi Journal of Biological Sciences | 2022 Apr 23
A systematic review and meta-analysis of trials assessing PD-1/PD-L1 immune checkpoint inhibitors activity in pre-treated advanced stage malignant mesothelioma
Marco Tagliamento, Paolo Bironzo
Critical Reviews in Oncology/Hematology | 2022 Apr 01
Design, synthesis, cytotoxic and enzyme inhibitory activities of 1,3,4-oxadiazole and 1,3,4-thiadiazine hybrids against non-small cell lung cancer
Abdelsalam Mohamed Abdelsalam Ouf, Heba Abdelrasheed Allam, ..., Salah A. Abdel-Aziz
Results in Chemistry | 2022 Jan 01
New Insights of the NEET Protein CISD2 Reveals Distinct Features Compared to Its Close Mitochondrial Homolog mitoNEET
Myriam Salameh, Sylvie Riquier, ..., Stefano Bellosta
Biomedicines | 2021 Apr 05 | 33916457
Computational high-throughput screening and in vitro approaches identify CB-006-3; A novel PI3K-BRAF V600E dual targeted inhibitor against melanoma
FAISAL HASSAN TOBEIGEI, REEM M. GAHTANI, ..., PRASANNA RAJAGOPALAN
Oncology Research | 2021 Jan 01
Dual SMO/BRAF Inhibition by Flavonolignans from Silybum marianum
Antonia Diukendjieva, Maya M. Zaharieva, ..., Ilza Pajeva
Antioxidants | 2020 May 05 | 32380762
Mitochondrial metabolic reprograming via BRAF inhibition ameliorates senescence
Jae Won Kim, Myeong Uk Kuk, ..., Joon Tae Park
Experimental Gerontology | 2019 Oct 01 | 31421186
在线留言
如果您对我们的产品感兴趣，请留下您的信息，我们将尽快与您联系，谢谢！
艾维缔官网
艾德官网
B站IVDSHOW
抖音军哥聊表观
视频号艾维缔
小红书艾维缔
快手表观盒子
表观遗传学
联系我们
