阿霉素

阿霉素，Doxorubicin，拓扑异构酶II（Topo II）抑制剂，免疫抑制抗肿瘤抗生素。更多视频请关注视频号【艾维缔】。哔哩哔哩【IVDSHOW】。抖音【军哥聊表观】。

关键词

阿霉素

所属分类

抑制剂

目录号

A3966

获取报价

IC50和靶点

生物活性描述

Doxorubicin（Adriamycin）是一种抗生素，DNA拓扑异构酶II的抑制剂，DNA损伤和细胞凋亡的诱导剂。

产品组分

内容	型号	规格	储存温度
阿霉素	A3966-01	10mg	-20°C
阿霉素	A3966-02	25mg	-20°C
阿霉素	A3966-03	100mg	-20°C
阿霉素	A3966-04	1ml(10mM in DMSO)	-20°C
操作手册	1	1	常温

文件资源

营销中心
注意事项

保存建议厂家推荐蓝冰运输。当您收到产品后，按照说明书建议保存于-20°C。
FAQ
1. Tatjana Maravic, Giulia Petrucci, et al. "In Vitro Study of Cold Atmospheric Plasma–Induced Proliferation Inhibition and Morphological Changes in Head and Neck Carcinoma Cell Lines." J Dent. 2025 Jul 29:161:106007 PMID: 40744292

2. Aimei Li, Xue Tian, et al. "Alkaline phosphatase-responsive peptide amphiphiles promote the apoptosis of HER2-positive breast cancer cells via increased drug accumulation." Colloids and Surfaces A: Physicochemical and Engineering Aspects. Volume 718, 5 August 2025, 136848.

3. Wenli Xie, Qing Xia, et al. "Structural characterization and cardioprotective activities of natural polysaccharides from Apocynum venetum L." Chem. Biol. Technol. Agric. 12, 81 (2025)

4. Yue Wang, Chen Wei, et al. "A pH-sensitive peptide amphiphilic-based drug delivery system inhibits hepatocellular carcinoma growth by suppressing hepatic stellate cell activation." Mater Today Bio. 2025 Apr 30:32:101821 PMID: 40453820

5. Ting Gao, Yufeng Tang, et al. "Neuraminidase 1 Exacerbated Glycolytic Dysregulation and Cardiotoxicity by Destabilizing SIRT1 through Interactions with NRF2 and HIF1α." Adv Sci (Weinh). 2025 May 24;12(25):2414504 PMID: 40411250

6. Xuan Wang, Qiqi Sun, Jianrong Li, Baoyong Lai, Xiaohua Pei, Nana Chen et al. "Effect of Fangxia-Dihuang Decoction on doxorubicin-induced cognitive impairment in breast cancer animal model." Front Oncol. 2025 Apr 28:15:1515498 PMID: 40356765

7. Lishuang Cui, Qing Xia, et al. "Luteolin - 7 - O - glucuronide alleviates doxorubicin - induced cardiotoxicity by inhibiting PPAR - mediated ferroptosis." Toxicol Appl Pharmacol. 2025 Jul:500:117381 PMID: 40345555

8. Asena Aynaci, Maxence Toussaint, et al. "Disruption of Man-6-P-Dependent Sorting to Lysosomes Confers IGF1R-Mediated Apoptosis Resistance." Int J Mol Sci . 2025 Apr 10;26(8):3586.

9. Ning Wang, Chenxi Qiao, et al. "Acetylation of Short Glycopeptides Enables Phase Separation." Biomacromolecules. 2025 Mar 10;26(3):1595-1603 PMID: 39903822

10. N Daneshvar Baghbadorani, M Bosso, et al. "A novel in vitro 3D cancer model based on modular tissue engineering approach." bioRxiv. March 01, 2025.

11. Kun Li, Kun-Mao Jiang, et al. "Inhibition of NETs prevents doxorubicin-induced cardiotoxicity by attenuating IL-18-IFN-γ-Cx43 axis induced cardiac conduction abnormalities." Int Immunopharmacol. 2025 Feb 6:147:114016 PMID: 39805175

12. Sookil Tae, Hye Yeon Lee, et al. "Senolytic and Senomorphic Effects of Lactobacillus plantarum DS0037 Derived Exosome-like Nanovesicles." Journal of the Society of Cosmetic Scientists of Korea Volume 50 Issue 4 / Pages.335-348 / 2024 / 1226-2587(pISSN) / 2288-9507(eISSN)

13. Shudan Wang, Mingcai Chen, et al. "Shexiang Baoxin Pills alleviate doxorubicin-induced cardiotoxicity via the reactive oxygen species-mediated AKT/Bcl-2 pathway." Published in Medicine 27 December 2024.

14. Min Wang, Fang Zhou, et al. "The transcription factor PPARA mediates SIRT1 regulation of NCOR1 to protect damaged heart cells." Cardiovascular Diagnosis & Therapy Vol 14, No 5 (October 31, 2024).

15. Siyuan Li, Wencheng Zhang, et al. "Serum sSelectin-L is an early specific indicator of radiation injury." Heliyon. 2024 May 8;10(10):e30527. PMID: 38778981

16. Ivonne González-Gamboa, Adam A Caparco, et al. "Inter-coat protein loading of active ingredients into Tobacco mild green mosaic virus through partial dissociation and reassembly of the virion." Sci Rep. 2024 Mar 26;14(1):7168. PMID: 38532056

17. Baiying Lei, et al. "Morphology-based deep learning enables accurate detection of senescence in mesenchymal stem cell cultures." BMC Biol. 2024 Jan 2;22(1):1. PMID: 38167069

18. Meng Wang, Dongfang Xie, et al. "Multiple ingredients of a Chinese medicine formula Sheng-Mai-San coordinately attenuate doxorubicin-induced cardiotoxicity." Pharmacological Research - Modern Chinese Medicine. Volume 8, September 2023, 100281.

19. Riley Plett, Paul Mellor, et al. "Homoharringtonine demonstrates a cytotoxic effect against triple-negative breast cancer cell lines and acts synergistically with paclitaxel." Sci Rep. 2022 Sep 19;12(1):15663. PMID: 36123435

20. Boqin Hu, Dong Zhen, et al. "Ethanol extracts of Rhaponticum uniflorum (L.) DC flowers attenuate doxorubicin-induced cardiotoxicity via alleviating apoptosis and regulating mitochondrial dynamics in H9c2 cells." J Ethnopharmacol. 2022 Apr 24;288:114936. PMID: 35007682

21. Hai-Bing Yang, Zhao-Yang Lu, et al. "Selenium Attenuates Doxorubicin-Induced Cardiotoxicity Through Nrf2-NLRP3 Pathway." Biol Trace Elem Res. 2021 Aug 30. PMID: 34462843

22. Ji Yun Lee, Joo Hyun Kim, et al. "EGR1 as a potential marker of prognosis in extranodal NK/T-cell lymphoma." Sci Rep. 2021 May 14;11(1):10342. PMID: 33990633

23. Zhongying Gong, Xiaoying Liu, et al. "Tumor acidic microenvironment-induced drug release of RGD peptide nanoparticles for cellular uptake and cancer therapy." Colloids Surf B Biointerfaces. 2021 Mar 4;202:111673. PMID: 33714186

24. Ji Yun Lee, Joo Hyun Kim, et al. "Gene Expression Profiling in Extranodal NK/T-Cell Lymphoma." Research Square. December 4th, 2020.

25. Wang X, Wang Q, et al. "TFEB-NF-κB inflammatory signaling axis: a novel therapeutic pathway of Dihydrotanshinone I in doxorubicin-induced cardiotoxicity." J Exp Clin Cancer Res. 2020;39(1):93. PMID: 32448281

26. Gong Z, Lao J, et al. "pH-Triggered geometrical shape switching of a cationic peptide nanoparticle for cellular uptake and drug delivery." Colloids Surf B Biointerfaces. 2020;188:110811. PMID: 31982793

27. Qi W, Boliang W, et al. "Cardamonin protects against doxorubicin-induced cardiotoxicity in mice by restraining oxidative stress and inflammation associated with Nrf2 signaling." Biomed Pharmacother. 2020;122:109547. PMID: 31918264

28. Gong Z, Shi Y, et al. "Plasma Amine Oxidase-Induced Nanoparticle-to-Nanofiber Geometric Transformation of an Amphiphilic Peptide for Drug Encapsulation and Enhanced Bactericidal Activity." ACS Appl Mater Interfaces. 2020;12(4):4323–4332. PMID: 31899611

29. Gong Z, Liu X, Wu J, et al. "pH-triggered morphological change in a self-assembling amphiphilic peptide used as an antitumor drug carrier." Nanotechnology. 2020;31(16):165601. PMID: 31891937

30. Yan L, Ding B, et al. "Inhibition of SMYD2 suppresses tumor progression by down-regulating microRNA-125b and attenuates multi-drug resistance in renal cell carcinoma." Theranostics. 2019 Oct 22;9(26):8377-8391. PMID: 31754403

31. Wang Z, Chen J, et al. "cGAS/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity." J Clin Invest. 2019 Aug 13;130:4850-4862. PMID: 31408442

32. Wang X, Li C, et al. "Tanshinone IIA Restores Dynamic Balance of Autophagosome/Autolysosome in Doxorubicin-Induced Cardiotoxicity via Targeting Beclin1/LAMP1." Cancers (Basel). 2019 Jun 28;11(7). pii: E910. PMID: 31261758

33. Zhang Y, Xia F, et al. "miR-135b-5p enhances doxorubicin-sensitivity of breast cancer cells through targeting anterior gradient 2." J Exp Clin Cancer Res. 2019 Jan 21;38(1):26. PMID: 30665445

34. Goodspeed A, Jean A, et al. "A Whole-genome CRISPR Screen Identifies a Role of MSH2 in Cisplatin-mediated Cell Death in Muscle-invasive Bladder Cancer." Eur Urol. 2019 Feb;75(2):242-250. PMID: 30414698

35. Deng Y, Li F, et al. "Triptolide sensitizes breast cancer cells to Doxorubicin through the DNA damage response inhibition." Mol Carcinog. 2018 Jun;57(6):807-814. PMID: 29500880

物理外观	A solid
CAS号	23214-92-8
分子式	C₂₇H₂₉NO₁₁
分子量	543.52
化学名称	(7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione
溶解度	≥27.2 mg/mL in DMSO; insoluble in EtOH; ≥24.8 mg/mL in H2O with ultrasonic
SMILES	CC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O
存储条件	4°C
运输条件	蓝冰
SDF文件	Download SDF

文件下载	文件内容	资源说明
	A3966-阿霉素	操作手册
	A3966-阿霉素相关单页	宣传单页

搜索历史清除全部记录

阿霉素

IC50和靶点

产品组分

文件资源

营销中心

注意事项

FAQ