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For general laboratory use.
Please centrifuge briefly before opening (volume ≤2 ml).Shipping: shipped at ambient temperature
Storage Conditions: store at -20 °C
Shelf Life: 12 months after date of delivery
Molecular Formula: C16H22N4O10
Molecular Weight: 430.37 g/mol
Exact Mass: 430.13 g/mol
CAS#: 361154-30-5
Purity: mass identification (ESI-MS)
Form: oil
Color: off-white to grey
Solubility: DMSO, DMF, MeOH
Applications:
Glycoconjugate synthesis monitoring by metabolic labelingDescription:
The tetraacetylated N-Azidoacetyl-mannosamine (Ac4ManNAz) provides a non-radioactive alternative for glycoconjugate visualization. It is cell-permeable, intracellularly processed and incorporated instead of its natural monosaccharide counterpart N-Acetylmannosamine(ManNAc).The resulting Azide-functionalized glycoconjugates can subsequently be detected via Cu(I)-catalyzed or Cu(I)-free Click Chemistry that offers the choice to introduce a Biotin group (via Azides of Biotin or DBCO-containing Biotin, respectively) for subsequent purification tasks or to introduce fluorescent group (via Azides of fluorescent dyes or DBCO-containing fluorescent dyes, respectively) for subsequent microscopic imaging.
Recommended concentration for metabolic labeling: 25-75 μM. This concentration range may serve as a starting point for an individual assay set-up.
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产品组分
内容
型号
规格 储存温度
Ac4ManNAz
CLK1084-01 5mg
-20 °C
Ac4ManNAz
CLK1084-02 25mg
-20 °C Ac4ManNAz
CLK1084-03 100mg
-20 °C 操作手册
1 1 常温
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营销中心
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注意事项
保存建议 厂家推荐蓝冰运输。当您收到产品后，按照说明书建议保存于-20°C。 -
FAQ
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Selected References:
Spiciarich et al. (2017) Bioorthogonal Labeling of Human Prostate Cancer Tissue Slice Cultures for Glycoproteomis. Angew. Chem. Int. Ed.129:1.Heat up, silence on: IDO1 gene silencing in THP-1-derived dendritic cells triggered by magnetic hyperthermia.
Daniela Ferreira, Laura Asín, ..., Alexandra R Fernandes
Cancer immunology, immunotherapy : CII | 2025 Aug 23 | 40848064
Proteins are a source of glycans found in preparations of glycoRNA
Kegel Nathanael B., Demirel Nurseda Yilmaz, ..., Bauer Stefan
bioRxiv | 2025 Mar 17
A Bioorthogonal Precision Tool for Human N -Acetylglucosaminyltransferase V.
Yu Liu, Ganka Bineva-Todd, ..., Benjamin Schumann
Journal of the American Chemical Society | 2024 Sep 17 | 39287665
Supplementary Expanding the repertoire of GalNAc analogues for cell-specific bioorthogonal tagging of glycoproteins
Abdul Zafar, Sandhya Sridhar, ..., Benjamin Schumann
RSC Chemical Biology | 2024 Aug 22 | 39238612
Cell surface RNA expression modulates alveolar epithelial function
Abledu Jubilant Kwame, Herbst Christopher J., ..., Kuebler Wolfgang M.
bioRxiv | 2024 May 21
Programmed immobilization of living cells using independent click pairs.
Chengyuan Zhu, Hiroyasu Takemoto, ..., Fumiyoshi Yamashita
Biochemical and biophysical research commu… | 2024 Feb 16 | 38277727
Golgi satellites are essential for polysialylation of NCAM and expression of LTP at distal synapses.
Maria Andres-Alonso, Maximilian Borgmeyer, ..., Michael R Kreutz
Cell reports | 2023 Jul 31 | 37355986
Module-assembly of injectable cellular DNA hydrogel via clickable cells and DNA scaffolds
Hyangsu Nam, Hyunsu Jeon, ..., Jong Bum Lee
Chemical Engineering Journal | 2023 Jan 01
From Bench to Cell: A Roadmap for Assessing the Bioorthogonal “Click” Reactivity of Magnetic Nanoparticles for Cell Surface Engineering
Javier Idiago-López, Eduardo Moreno-Antolín, ..., Raluca M. Fratila
Bioconjugate chemistry | 2022 Jul 20 | 35857350
Antibody Recognition of Cancer Cells via Glycan Surface Engineering
Mathieu Szponarski, Karl Gademann
ChemBioChem | 2022 Jun 20 | 35638149
Metabolic Glycoengineering in hMSC-TERT as a Model for Skeletal Precursors by Using Modified Azide/Alkyne Monosaccharides
Stephan Altmann, Jürgen Mut, ..., Grzegorz Wegrzyn
International Journal of Molecular Science… | 2021 Mar 10 | 33802220
Click Chemistry-mediated Biotinylation Reveals a Function for the Protease BACE1 in Modulating the Neuronal Surface Glycoproteome
Julia Herber, Jasenka Njavro, ..., Stefan F. Lichtenthaler
Molecular & Cellular Proteomics | 2018 Aug 01
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