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For general laboratory use.
Please centrifuge briefly before opening (volume ≤2 ml).Shipping: shipped on gel packs
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.Shelf Life: 12 months after date of delivery
Molecular Formula: C11H16N5O8P (free acid)
Molecular Weight: 377.25 g/mol (free acid)
Exact Mass: 377.07 g/mol (free acid)
CAS#: 47442-17-1
Purity: ≥ 95 % (HPLC)
Form: solution in water
Color: colorless to slightly yellow
Concentration: 10 mM - 11 mM
pH: 7.5 ±0.5
Spectroscopic Properties: λmax 258/280 nm, ε 9.8/8.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Applications:
Association to human scavenger decapping enzyme[1]
Inhibition of methyltransferase activity[2] -
产品组分
内容
型号
规格 储存温度
m7GMP
NU1135-01 100ul(10mM)
-20 °C
m7GMP
NU1135-02 500ul(10mM)
-20 °C 操作手册
1 1 常温
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营销中心
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注意事项
保存建议 厂家推荐蓝冰运输。当您收到产品后，按照说明书建议保存于-20°C。 -
FAQ
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Selected References:
[1] Darzynkiewicz et al. (2007) Interaction of human decapping scavenger with 5-mRNA cap analogues: structural requirements for catalytic activity. Journal of Physics: Condensed Matter 19:285217/1.
[2] Magden et al. (2001) Virus-specific mRNA capping enzyme encoded by hepatitis E virus. J. Virology 75:6249.
Shen et al. (2001) Structural and thermodynamic behavior of eukaryotic initiation factor 4E in supramolecular formation with 4E-binding protein 1 and mRNA cap analogue, studied by spectroscopic methods. Chem Pharm Bull 49 (10):1299.
Carberry et al. (1989) A spectroscopic study of the binding of m7GTP and m7GpppG to human protein synthesis initiation factor 4E. Biochemistry 28 (20):8078.
Beemon et al. (1977) In vitro translation yields a possible Rous sarcoma virus src gene product. Proc Natl Acad Sci U S A. 74 (8):3302.Identification of ALKBH6 as a nucleotide demethylase with a distinct substrate preference.
Susmita Das, Sourbh Rankawat, ..., Roy Anindya
The Journal of biological chemistry | 2025 Aug 28 | 40885392
The evaluation of DNA-linked inhibitor antibody and AlphaScreen assays for high-throughput screening of compounds targeting the cap-binding domain in influenza a polymerase.
Kateřina Čermáková, Jiří Gregor, ..., Milan Kožíšek
European journal of pharmaceutical science… | 2024 Dec 12 | 39674552
A rust-fungus Nudix hydrolase effector decaps mRNA in vitro and interferes with plant immune pathways.
Carl L McCombe, Ann-Maree Catanzariti, ..., Simon J Williams
The New phytologist | 2023 Jun 02 | 36631975
Alphaherpesvirus US3 protein-mediated inhibition of the m6A mRNA methyltransferase complex
Robert J.J. Jansens, Ruth Verhamme, ..., Herman W. Favoreel
Cell reports | 2022 Jul 29 | 35858564
Selective detection of m 6 A derived from mRNA using the Phospho-tag m 6 A assay
Mirza Aashiq H., Attarwala Nabeel, ..., Jaffrey Samie R.
bioRxiv | 2022 May 24
Crystal Structures of the Novel Cytosolic 5′-Nucleotidase IIIB Explain Its Preference for m 7 GMP
Thomas Monecke, Juliane Buschmann, ..., Petri Kursula
PLoS ONE | 2014 Mar 06 | 24603684
Identification of Drosophila and Human 7-Methyl GMP-specific Nucleotidases
Juliane Buschmann, Bodo Moritz, ..., Elmar Wahle
The Journal of biological chemistry | 2013 Jan 25 | 23223233
Development of biochemical assays for the identification of eIF4E-specific inhibitors.
Carlo Visco, Claudia Perrera, ..., Paola Magnaghi
Journal of biomolecular screening | 2012 Sep 12 | 22392810
Allosteric regulation of Argonaute proteins by miRNAs
Sergej Djuranovic, Michelle Kim Zinchenko, ..., Rachel Green
pmc02834277 | 2010 Jan 10 | 20062058
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