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For general laboratory use.
Shipping: shipped at ambient temperature
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.Shelf Life: 12 months after date of delivery
Molecular Formula: C11H14N2O6
Molecular Weight: 270.24 g/mol
Exact Mass: 270.09 g/mol
CAS#: 55520-64-4
Purity: ≥ 98 % (HPLC)
Form: solid
Color: white to off-white
Solubility: DMSO, methanol
Spectroscopic Properties: λmax 288 nm, ε 8.5 L mmol-1 cm-1 (Methanol)
Applications:
RNA synthesis monitoring[1]Description:
5-VU (5-Vinyl-uridine) can be used as a replacement for BrU (5-Bromo-uridine) or the copper-catalyst requiring 5-EU (5-Ethynyl-uridine) to measure de novo RNA synthesis in proliferating cells [1]. 5-VU is cell permeable and incorporates into nascent RNA instead of its natural analog uridine.The resulting vinyl-functionalized RNA can subsequently be detected via Cu(I)-free Alkene-Tetrazine Ligation that offers the choice to introduce a Biotin group (via Tetrazines of Biotin) for subsequent purification tasks or a fluorescent group (via Tetrazines of fluorescent dyes) for subsequent microscopic imaging.
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产品组分
内容
型号
规格 储存温度
5-乙烯基尿苷(5-VU)
CLK049-01 10mg
-20 °C
5-乙烯基尿苷(5-VU)
CLK049-02 50mg
-20 °C 操作手册
1 1 常温
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营销中心
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注意事项
保存建议 厂家推荐蓝冰运输。当您收到产品后，按照说明书建议保存于-20°C。 -
FAQ
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Selected References:
[1] Liu et al. (2019) A Nucleoside Derivative 5-Vinyluridine (VrU) for Imaging RNA in Cells and Animals. Bioconjug. Chem. 30 (11):2958.Supplementary Mutually Orthogonal Bioconjugation of Vinyl Nucleosides for RNA Metabolic Labeling.
Mrityunjay Gupta, Monika Singha, ..., Robert C Spitale
Organic Letters | 2021 Sep 08 | 34496205
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