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For general laboratory use.
Shipping: shipped on gel packs
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.Shelf Life: 12 months after date of delivery
Molecular Formula: C20H24N10O13P2 (free acid)
Molecular Weight: 674.42 g/mol (free acid)
Exact Mass: 674.10 g/mol (free acid)
Purity: ≥ 98 % (HPLC) / ≤ 2.5 EU/ml Endotoxin (LAL test)
Form: solid (lyophilized from filtered (10 kDa) solution in water)
Color: white to off-white
Spectroscopic Properties: λmax 260 nm, ε 25.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)
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产品组分
内容
型号
规格 储存温度
2'3'-环鸟苷酸-腺苷酸(2',3'-cGAMP)
NU249-01 1umol
-20 °C
2'3'-环鸟苷酸-腺苷酸(2',3'-cGAMP)
NU249-02 5x1umol
-20 °C 操作手册
1 1 常温
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营销中心
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注意事项
保存建议 厂家推荐蓝冰运输。当您收到产品后，按照说明书建议保存于-20°C。 -
FAQ
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Selected References:
Li et al. (2018) The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer. J. Exp. Med. 215 (5):1287.
Li et al. (2016) Antitumor activity of cGAMP via stimulation of cGAS-cGAMP-STING-IRF3 mediated innate immune response. Nature Scientific Reports 6:19049.
Tao et al. (2016) cGAS-cGAMP-STING: The three musketeers of cytosolic DNA sensing and signaling. IUBMB Life 68 (11):858.
Temizoz et al. (2015) TLR9 and STING agonists synergistically induce innate and adaptive type-II IFN. Eur. J. Immunol. 45:1159.
Wenzl et al. (2024) How enzyme-centered approaches are advancing research on cyclic oligo-nucleotides. FEBS Lett.598(8): 839.Single-stranded DNA binding to the transcription factor PafBC triggers the mycobacterial DNA damage response.
Charlotte M Schilling, Rafal Zdanowicz, ..., Eilika Weber-Ban
Science advances | 2025 Feb 07 | 39919186
Intercellular cGAMP transmission induces innate immune activation and tissue inflammation in Trex1 deficiency.
Bianca B Jütte, Calvin Krollmann, ..., Lino L Teichmann
iScience | 2021 Aug 20 | 34368651
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