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冠状病毒（CoVs）主要会导致人类和动物患上多种呼吸道及肠道感染疾病。木瓜样蛋白酶（PLPro），也称为PLP，在病毒复制过程中的多肽加工方面发挥着关键作用。PLPro还被认为是SARS-CoV-2持续致病过程中的一种关键酶。PLP作为一种去泛素化酶，能从宿主细胞蛋白上移除泛素和ISG15，从而帮助冠状病毒逃避宿主的先天性抗病毒免疫反应。因此，PLPro是抗病毒药物的重要潜在靶点，这类药物或许能抑制病毒复制，同时减轻受感染细胞中信号级联反应的失调，而这种失调可能会导致周围未受感染的细胞死亡。能够阻断病毒复制的PLPro抑制剂是很有前景的潜在候选药物，可用于治疗感染新冠病毒的患者。
木瓜样蛋白酶(SARS-CoV-2)活性检测试剂盒旨在测量木瓜蛋白酶样蛋白酶的活性，适用于筛选和谱分析应用，采用均相检测法，无需耗时的洗涤步骤。
Assay Kit Format
Fluorogenic
Species
SARS-CoV-2
Supplied As
The kit comes in a convenient 96-well or 384-well format, with purified Papain-like Protease, fluorogenic substrate, and PLPro assay buffer for 100 or 384 enzyme reactions. PLPro inhibitor GRL0617 is also included as a positive control.
Materials Required But Not Supplied
Fluorescent microplate reader capable of reading λexc/λem=360 nm/460 nm
Target(s)
SAR-CoV-2
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产品组分
内容 型号
规格 储存温度
木瓜样蛋白酶(SARS-CoV-2)活性检测试剂盒
CN79995-01 96次
-20°C 木瓜样蛋白酶(SARS-CoV-2)活性检测试剂盒
CN79995-02 384次
-20°C 操作手册
1 1 常温
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营销中心
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注意事项
保存建议 厂家推荐蓝冰运输。当您收到产品后，按照说明书建议保存于-20°C。 -
FAQ
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References
Weglarz-Tomczak, E. et al., 2020. https://doi.org/10.1101/2020.05.17.100768.
Anti-Infective Screening of Selected Nine Cannabinoids Against Clostridium perfringens and Influenza A (H5N1) Neuraminidases, and SARS-CoV-2 Main Protease and Spike Protein Interactions.
Thanet Pitakbut, Oliver Kayser
Current Issues in Molecular Biology | 2025 Mar 12 | 40136439
Diacerein reduces inflammasome activation and SARS-CoV-2 virus replication: a proof-of-concept translational study
Helison R. P. Carmo, Alejandro Rossel Castillo, ..., Andrei C. Sposito
Frontiers in Pharmacology | 2024 Oct 07
Targeting papain-like protease by natural products as novel therapeutic potential SARS-CoV-2.
Muhammad Waqas, Saeed Ullah, ..., Ahmed Al-Harrasi
International journal of biological macrom… | 2023 Dec 17 | 38114011
Discovery of novel papain-like protease inhibitors for potential treatment of COVID-19.
Fatema Hersi, Anusha Sebastian, ..., Taleb H Al-Tel
European Journal of Medicinal Chemistry | 2023 May 08 | 37075625
Patent Anti-SARS CoV-2 inhibitors by dual viral-host targeting
Sameh S. M. Soliman, Bahgat Fayed, ..., Ahmed M. Almehdi
us11608331 | 2023 Mar 21
Agathisflavone, a natural biflavonoid that inhibits SARS-CoV-2 replication by targeting its proteases
Otávio Augusto Chaves, Carlyle Ribeiro Lima, ..., Thiago Moreno L. Souza
International journal of biological macrom… | 2022 Sep 29
Targeting proteases involved in the viral replication of SARS-CoV-2 by sesquiterpene lactones from chicory ( Cichorium intybus L.).
María Ángeles Ávila-Gálvez, Carlos Rafael-Pita, ..., Cláudia Nunes Dos Santos
Food & function | 2022 Sep 01 | 35938740
Identification of a Papain-Like Protease Inhibitor with Potential for Repurposing in Combination with an M pro Protease Inhibitor for Treatment of SARS-CoV-2
Campagna Jesus, Jagodzinska Barbara, ..., John Varghese
bioRxiv | 2022 Jul 18
Natural Polyphenols, 1,2,3,4,6-O-Pentagalloyglucose and Proanthocyanidins, as Broad-Spectrum Anticoronaviral Inhibitors Targeting Mpro and RdRp of SARS-CoV-2
Young-Hee Jin, Jihye Lee, Toshihiro Kita
Biomedicines | 2022 May 18 | 35625907
Thiazole/Thiadiazole/Benzothiazole Based Thiazolidin-4-One Derivatives as Potential Inhibitors of Main Protease of SARS-CoV-2
Anthi Petrou, Panagiotis Zagaliotis, Loredana Salerno
Molecules | 2022 Mar 28 | 35408577
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