ATPαS

ATPαS，5'-O-(1-硫代三磷酸)腺苷钠盐（Rp和Sp异构体混合物），Adenosine-5'-(α-thio)-triphosphate, Sodium salt; (Mixture of Rp and Sp isomers)，5'-腺苷基-(α-硫代)-三磷酸钠盐（Rp和Sp异构体的混合物）。更多视频请关注视频号【艾维缔】。哔哩哔哩【IVDSHOW】。抖音【军哥聊表观】。

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ATPαS

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IVDEpi

目录号

NU408

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For general laboratory use.

Please centrifuge briefly before opening (volume ≤2 ml).

Shipping: shipped on gel packs

Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Shelf Life: 12 months after date of delivery

Molecular Formula: C₁₀H₁₆N₅O₁₂P₃S (free acid)

Molecular Weight: 523.24 g/mol (free acid)

Exact Mass: 522.97 g/mol (free acid)

CAS#: 29220-54-0

Purity: ≥ 95 % (HPLC)

Form: solution in water

Color: colorless to slightly yellow

Concentration: 100 mM - 110 mM

pH: 7.5 ±0.5

Spectroscopic Properties: λ_max 259 nm, ε 15.4 L mmol^-1 cm^-1 (Tris-HCl pH 7.5)

Applications:
Crystal structure in complex with adenylyl cyclase^[1]
Activation of beta-cell adenylyl cyclase^[2]
Potent agonist for P2Y11-receptor^[3]
Full agonist for rP2Y1-receptor^[4]

Specific Ligands:

Binding to P2Y2- and P2Y6-receptors^[5]

Ligand for purinergic receptors:
P2Y^[2,5,7]
P2Y₂^[6]
P2Y₁₁^[3]
关键词:
- ATPαS

产品组分

内容	型号	规格	储存温度
ATPαS	NU408-01	25ul(100mM)	-20°C
ATPαS	NU408-02	125ul(100mM)	-20°C
操作手册		1	常温

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FAQ
Selected References:
[1] Segura-Pena et al. (2007) Quartenary structure change as a mechanism for the regulation of thymidine kinase 1-like enzymes. Structure 15:1555.
[2] Ostermann et al. (2003) Structure of human thhymidilate kinase in complex with prodrugs:Implications for the structure-based design of novel compounds. Biochemistry 42:2568.
[3] Shimizu et al. (1997) Hydrolysis of AMPPNP by the motor domain of NCD, a kinesin-related protein. Mol. Biol. Cell 8:1497.
[4] Suzuki et al. (1997) Hydrolysis of AMPPNP by the motor domain of ncd, a kinesin-related protein. FEBS Lett. 409 (1):29.
[5] Lazarowski et al. (1995) Pharmacological selectivity of cloned human P2U-purinoreceptor: potent activation by diadenosine tetraphosphate. Br. J. Pharmacol. 116 (1):1619.
Bodey et al. (2009) 9-Angström structure of a microtubule-bound mitotic motor. J. Mol. Biol. 388 (2):218.
Karow et al. (2009) A conformational change in the helicase core is necessary but not sufficient for RNA unwinding by the DEAD box helicase YxiN. Nucleic Acids Research 37 (13):4464.
Chang et al. (2005) Nitric Oxide-dependent Allosteric Inhibitory Role of a Second Nucleotide Binding Site in Soluble Guanylyl Cyclase. J. Biol. Chem. 280 (12):11513.
Menendez-Arias et al. (2005) Supression of Multidrug-resistant HIV-1 Reverse Transscriptase Primer Unblocking Activity by a-Phosphate-modified Thymidine Analogues. J. Mol. Biol. 349 (3):451.
Menz et al. (2001) The structure and nucleotide occupancy of bovine mitochondrial F-1-ATPase are not influenced by crystallisation at high concentrations of nucleotide. FEBS Lett. 494 (1):11.
Tereshko et al. (2001) Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression. Nat. Struct. Biol. 8 (10):899.
Prodromou et al. (2000) The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domains. EMBO J. 19 (16):4383.
Gil et al. (1999) N-Acetyl-L-glutamate kinase from Escherichia coli: cloning of the gene, purification and crystallization of the recombinant enzyme and preliminary X-ray analysis of the free and ligand-bound forms. Acta Cryst. D 55:1350.
Shi et al. (1999) EDC cross-linking of actin and myosin S1. II. AMPPNP induces an allosteric transition from pre-hydrolysis state to posthydrolysis state. Biophys. J. 76 (1):A163.
Williams et al. (1986) Effects of purine nucleotides on the binding of [3H]cyclopentyladenosine to adenosine A1-receptors in rat brain membranes. J. Neurochem. 47 (1):88.

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