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FCCP是线粒体中一种强效的氧化磷酸化解偶联剂,它通过跨细胞膜运输质子来破坏ATP的合成。1,2在40μM浓度下,FCCP会通过破坏线粒体的H+梯度来提高细胞内pH值,并通过削弱微管相关蛋白的结合能力降低微管的稳定性,从而诱导微管完全解聚。3
Technical Information
Formal Name
2-
[2- [4- (trifluoromethoxy)phenyl]hydrazinylidene]- propanedinitrile CAS Number
370-86-5
Synonyms
- Trifluoromethoxy carbonylcyanide phenylhydrazone
Molecular Formula
C10H5F3N4O
Formula Weight
254.2
Purity
≥98%
Formulation
A crystalline solid
Solubility
DMSO: 25 mg/ml
λmax
240, 356 nm
SMILES
N#C/C(C#N)=N/NC1=CC=C(OC(F)(F)F)C=C1
InChi Code
InChI=1S/C10H5F3N4O/c11-10(12,13)18-9-3-1-7(2-4-9)16-17-8(5-14)6-15/h1-4,16H
InChi Key
BMZRVOVNUMQTIN-UHFFFAOYSA-N
关键词:- FCCP
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产品组分
内容
型号
规格 储存温度
FCCP
15218-01 10mg
-20°C FCCP
15218-02 50mg
-20°C 操作手册
1 1 常温
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注意事项
保存建议 厂家推荐蓝冰运输。当您收到产品后,按照说明书建议保存于-20°C。 -
FAQ

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Product Description References
1. Parker, V.H. Uncouplers of rat-
liver mitochondrial oxidative phosphorylation. Biochem. J. 97(3), 658-662 (1965). 2. Benz, R., and McLaughlin, S. The molecular mechanism of action of the proton ionophore FCCP (carbonylcyanide p-
trifluoromethoxyphenylhydrazone). Biophys. J. 41(3), 381-398 (1983). 3. Maro, B., Marty, M.C., and Bornens, M. In vivo and in vitro effects of the mitochondrial uncoupler FCCP on microtubules. EMBO J. 1(11), 1347-1352 (1982).
Product Citations
Nagakannan, P., Islam, M.I., Conrad, M., et al. Cathepsin B is an excutioner of ferroptosis. Biochim. Biophys. Acta Mol. Cell Res. 1868(3), 118928 (2021).
Soriano-Castell, D., Currais, A., and Maher, P. Defining a pharmacological inhibitor fingerprint for oxytosis/ferroptosis. Free Radic. Biol. Med. S0891-5849(21), (2021).
Izreig, S., Gariepy, A., Kaymak, I., et al. Repression of LKB1 by miR-
17~92 sensitizes MYC- dependent lymphoma to biguanide treatment. Cell Rep. Med. 1(2), 100014 (2020). Varalda, M., Antona, A., Bettio, V., et al. Psychotropic drugs show anticancer activity by disrupting mitochondrial and lysosomal function. Front. Oncol. 10, 562196 (2020).
Holmila, R.J., Vance, S.A., Chen, X., et al. Mitochondria-
targeted probes for imaging protein sulfenylation. Sci. Rep. 8(1), 6635 (2018).
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