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CCCP是一种质子载体线粒体解偶联剂,可增加膜对质子的通透性,导致线粒体膜电位破坏。1 当浓度分别为110 nM和35 nM时,它会抑制线粒体呼吸和ATP酶活性。2 在RAW 264.7细胞中,当浓度为50 µM时,CCCP可抑制干扰素基因刺激因子(STING)的激活,降低STING下游靶标(包括IFN-β、TBK1和IRF3)的表达。3 它以依赖于GTP酶Drp1的方式诱导线粒体分裂。在大鼠中,CCCP(4 mg/kg)会使体温升高,左心室收缩和舒张尺寸增大,并降低短轴缩短率。4 它还会增加大鼠心肌对葡萄糖和脂肪酸的摄取。
Technical Information
Formal Name
2-[2-(3-
chlorophenyl) hydrazinyli dene]-propan edinitrile CAS Number
555-60-2
Synonyms
- Carbonyl cyanide m-chlorophenyl hydrazone
- NSC 88124
Molecular Formula
C9H5ClN4
Formula Weight
204.6
Purity
≥98%
Formulation
A crystalline solid
Solubility
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 2 mg/mlPBS (pH 7.2): 0.1 mg/ml
λmax
248, 353 nm
SMILES
ClC1=CC=CC(N/N=C(C#N)\C#N)=C1
InChi Code
InChI=1S/C9H5ClN4/c10-7-2-1-3-8(4-7)13-14-9(5-11)6-12/h1-4,13H
InChi Key
UGTJLJZQQFGTJD-UHFFFAOYSA-N
关键词:- CCCP
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产品组分
内容
型号
规格 储存温度
CCCP
25458-01 100mg
-20°C CCCP
25458-02 250mg
-20°C CCCP
25458-03 500mg
-20°C 操作手册
1 1 常温
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注意事项
保存建议 厂家推荐蓝冰运输。当您收到产品后,按照说明书建议保存于-20°C。 -
FAQ

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Product Description References
1. Parker, V.H. Uncouplers of rat-
liver mitochondrial oxidative phosphorylation. Biochem. J. 97(3), 658-662 (1965). 2. Benz, R., and McLaughlin, S. The molecular mechanism of action of the proton ionophore FCCP (carbonylcyanide p-
trifluoromethoxyphenylhydrazone). Biophys. J. 41(3), 381-398 (1983). 3. Maro, B., Marty, M.C., and Bornens, M. In vivo and in vitro effects of the mitochondrial uncoupler FCCP on microtubules. EMBO J. 1(11), 1347-1352 (1982).
Product Citations
Nagakannan, P., Islam, M.I., Conrad, M., et al. Cathepsin B is an excutioner of ferroptosis. Biochim. Biophys. Acta Mol. Cell Res. 1868(3), 118928 (2021).
Soriano-Castell, D., Currais, A., and Maher, P. Defining a pharmacological inhibitor fingerprint for oxytosis/ferroptosis. Free Radic. Biol. Med. S0891-5849(21), (2021).
Izreig, S., Gariepy, A., Kaymak, I., et al. Repression of LKB1 by miR-
17~92 sensitizes MYC- dependent lymphoma to biguanide treatment. Cell Rep. Med. 1(2), 100014 (2020). Varalda, M., Antona, A., Bettio, V., et al. Psychotropic drugs show anticancer activity by disrupting mitochondrial and lysosomal function. Front. Oncol. 10, 562196 (2020).
Holmila, R.J., Vance, S.A., Chen, X., et al. Mitochondria-
targeted probes for imaging protein sulfenylation. Sci. Rep. 8(1), 6635 (2018).
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