依拉斯汀

依拉斯汀，Erastin，一种铁死亡（Ferroptosis）激活剂。更多视频请关注视频号【艾维缔】。哔哩哔哩【IVDSHOW】。抖音【军哥聊表观】。

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依拉斯汀

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抑制剂

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B1524

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爱拉斯汀（Erastin）是细胞渗透性ferroptosis的激活剂和抗肿瘤剂，对表达致癌基因RAS的细胞具有选择性。

Ferroptosis是一种独特的铁依赖的非凋亡性细胞死亡形式。Ferroptosis由致命小分子erastin引发，该化合物对癌基因RAS具有选择性。Ferroptosis的激活导致癌细胞的非凋亡性损伤。

在BJ-TERT/LT/ST/RASV12细胞中，erastin引发一种迅速的、氧化的和非凋亡性的细胞死亡过程。Erastin对人癌细胞产生致命性损伤，这些细胞具有参与 RAS-RAF-MEF通路的突变致癌基因HRAS、KRAS和BRAF，erastin是通过调节VDAC（电压依赖性阴离子通道）起作用的[1]。在HT 1080细胞中，erastin诱导的细胞死亡引发了细胞溶质ROS的累积，而且诱导的氧化性死亡是铁依赖性的。Erastin也抑制非依赖性的胱氨酸/谷氨酸逆向转运体XC-系统的活性[2]。

物理外观	A solid
CAS号	571203-78-6
分子式	C₃₀H₃₁ClN₄O₄
分子量	547.04
化学名称	2-[1-[4-[2-(4-chlorophenoxy)acetyl]piperazin-1-yl]ethyl]-3-(2-ethoxyphenyl)quinazolin-4-one
溶解度	insoluble in H2O; insoluble in EtOH; ≥10.92 mg/mL in DMSO with gentle warming
SMILES	O=C1N(C2=CC=CC=C2OCC)C(C(N3CCN(C(COC4=CC=C(Cl)C=C4)=O)CC3)C)=NC5=C1C=CC=C5
存储条件	-20°C
运输条件	蓝冰
SDF文件	Download SDF

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依拉斯汀 B1524-01
1mg
-20°C
依拉斯汀 B1524-02 5mg -20°C
依拉斯汀 B1524-03 10mg -20°C
依拉斯汀 B1524-04 25mg -20°C
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1 1
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保存建议厂家推荐蓝冰运输。当您收到产品后，按照说明书建议保存于-20°C。
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参考文献：
[1] Yagoda N, von Rechenberg M, Zaganjor E, Bauer AJ, Yang WS, Fridman DJ, Wolpaw AJ, Smukste I, Peltier JM, Boniface JJ, Smith R, Lessnick SL, Sahasrabudhe S, Stockwell BR.RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels.Nature. 2007 Jun 14;447(7146):864-8.

[2] Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B 3rd, Stockwell BR.Ferroptosis: an iron-dependent form of nonapoptotic cell death.Cell. 2012 May 25;149(5):1060-72.

1. Weiyu Tian, Zijing Yang, et al. "SIRT3 mitigates osteoarthritis by suppressing ferroptosis through activating AMPK signaling pathway." Cell Signal. 2025 Aug 14:135:112063. PMID: 40818538

2. Mengyun Yang, Ze Yu, et al. "Targeting lipid scrambling potentiates ferroptosis and triggers tumor immune rejection." Sci Adv. 2025 Aug 15;11(33):eadx6587. PMID: 40815641

3. Tanvi Gupta, Shang-Rung Wu, et al. "Radiocleavable rare-earth nanoactivators targeting over-expressed folate receptors induce mitochondrial dysfunction and remodel immune suppressive microenvironment in pancreatic cancer." J Nanobiotechnology. 2025 Aug 12;23(1):562. PMID: 40797208

4. Amy E Stewart, Derek K Zachman, et al. "Pathway Coessentiality Map** Reveals Complex II is Required for de novo Purine Biosynthesis in Acute Myeloid Leukemia." bioRxiv. 2025 Mar 2:2025.02.26.640463. PMID: 40060603

5. Leif R Neitzel, Daniela T Fuller, et al. "Inhibition of GPR68 induces ferroptosis and radiosensitivity in diverse cancer cell types." Sci Rep.2025 Feb 3;15(1):4074. PMID: 39900965

6. Elizabeth Jose, Woody March-Steinman, et al. "Temporal coordination of the transcription factor response to H2O2 stress." Nat Commun. 2024 Apr 23;15(1):3440. PMID: 38653977

7. Xin Li, Yanan Hu, et al. "Exosomal let-7a-5p derived from human umbilical cord mesenchymal stem cells alleviates coxsackievirus B3-induced cardiomyocyte ferroptosis via the SMAD2." J Zhejiang Univ Sci B. 2024 May 15;25(5):422-437. PMID: 38725341

8. Chenyang Fan, Xiaohong Guo, et al. "BRD4 inhibitors broadly promote erastin-induced ferroptosis in different cell lines by targeting ROS and FSP1." Discov Oncol. 2024 Apr 3;15(1):98. PMID: 38565708

9. Chen-Yi Wang, Mu-Yu Li, et al. "Rack1‐mediated ferroptosis affects hindgut development in rats with anorectal malformations: Spatial transcriptome insights." Cell Prolif. 2024 Mar 25:e13618. PMID: 38523594

10. Miaomiao Shao, Kangwei Qi, et al. "E3 ubiquitin ligase CHIP interacts with transferrin receptor 1 for degradation and promotes cell proliferation through inhibiting ferroptosis in hepatocellular carcinoma." Cell Signal. 2024 Jun:118:111148. PMID: 38521179

11. Hong-Feng Gu, et al. "Artemisinin ameliorates cognitive decline by inhibiting hippocampal neuronal ferroptosis via Nrf2 activation in T2DM mice." Mol Med. 2024 Mar 7;30(1):35. PMID: 38454322

12. Charles C. Hong, et al. "GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment." Exp Hematol Oncol. 2024 Jan 31;13(1):13. PMID: 38291540

13. Zhi-Jun Ou, et al. "The oxidized phospholipid PGPC impairs endothelial function by promoting endothelial cell ferroptosis via FABP3." J Lipid Res. 2024 Feb;65(2):100499. PMID: 38218337

14. Yang Wang, Hongmei Ding, et al. "Alleviated NCOA4-mediated ferritinophagy protected RA FLSs from ferroptosis in lipopolysaccharide-induced inflammation under hypoxia." Inflamm Res. 2024 Mar;73(3):363-379. PMID: 38189810

15. Krishan Kumar Saini, Priyank Chaturvedi, et al. "Loss of PERK function promotes ferroptosis by downregulating SLC7A11 (System Xc⁻) in colorectal cancer." Redox Biol. 2023 Sep;65:102833. PMID: 37536085

16. Qingyu Zhang, Ning Li, et al. "ACSL1-induced ferroptosis and platinum resistance in ovarian cancer by increasing FSP1 N-myristylation and stability." Cell Death Discov. 2023 Mar 8;9(1):83. PMID: 36882396

17. Dong S, Zheng L, et al. "Loss of Lactate/Proton Monocarboxylate Transporter 4 Induces Ferroptosis via the AMPK/ACC Pathway and Inhibition of Autophagy on Human Bladder Cancer 5637 Cell Line" J Oncol 2023;2023 PMID: 36718218

18. Li J, Li W, et al. "Development and validation of a novel ferroptosis‑related lncRNA prognostic signature for pancreatic adenocarcinoma." Mol Med Rep 2023 Feb;27(2) PMID: 36660936

19. Yang Liu, Libo He, et al. "Pharmacological inhibition of sphingolipid synthesis reduces ferroptosis by stimulating the HIF-1 pathway." iScience. 2022 Jun 6;25(7):104533. PMID: 35784791

20. Weilin Liu, Hongqi Chen, et al. "Ferroptosis Inducer Improves the Efficacy of Oncolytic Virus-Mediated Cancer Immunotherapy." Biomedicines. 2022 Jun 15;10(6):1425. PMID: 35740445

21. Xinxin Ren, Xiang Wang, et al. "Integrative bioinformatics and experimental analysis revealed TEAD as novel prognostic target for hepatocellular carcinoma and its roles in ferroptosis regulation." Aging (Albany NY). 2022 Jan 25;14(2):961-974. PMID: 35077390

22. Zixin Zhu, Ya Zhang, et al. "Thymosin beta 4 alleviates non-alcoholic fatty liver by inhibiting ferroptosis via up-regulation of GPX4." Eur J Pharmacol. 2021 Oct 5;908:174351. PMID: 34280397

23. Zongbo Wei, Caili Hao, et al. "Aging lens epithelium is susceptible to ferroptosis." Free Radic Biol Med. 2021 May 1;167:94-108. PMID: 33722625

24. Xinzhi Yang, Jiangang Liu, et al. "miR-18a promotes glioblastoma development by down-regulating ALOXE3-mediated ferroptotic and anti-migration activities." Oncogenesis. 2021 Feb 12;10(2):15. PMID: 33579899

25. Ali Ghoochani, En-Chi Hsu, et al. "Ferroptosis inducers are a novel therapeutic approach for advanced prostate cancer." Cancer Res. 2021 Mar 15;81(6):1583-1594. PMID: 33483372

26. Zhijun Liu, Himani Nailwal, et al. "A class of viral inducer of degradation of the necroptosis adaptor RIPK3 regulates virus-induced inflammation." Immunity. 2021 Feb 9;54(2):247-258.e7. PMID: 33444549

27. Qi Wang, Yaxun Guo, et al. "RNA binding protein DAZAP1 promotes HCC progression and regulates ferroptosis by interacting with SLC7A11 mRNA." Exp Cell Res. 2021 Feb 1;399(1):112453. PMID: 33358859

28. Hu Z, Zhang H, et al. "VDR activation attenuate cisplatin induced AKI by inhibiting ferroptosis." Cell Death Dis. 2020;11(1):73. Published 2020 Jan 29. PMID: 31996668

29. Zhou HH, Chen X, et al. "Erastin Reverses ABCB1-Mediated Docetaxel Resistance in Ovarian Cancer." Front Oncol, 9, 1398 2019 Dec PMID: 31921655

30. Wang H, Liu C, et al. "Inhibition of LONP1 protects against erastin-induced ferroptosis in Pancreatic ductal adenocarcinoma PANC1 cells." Biochem Biophys Res Commun. 2019 Dec 7. pii: S0006-291X(19)32315-0. PMID: 31822343

内容	型号	规格	储存温度
依拉斯汀	B1524-01	1mg	-20°C
依拉斯汀	B1524-02	5mg	-20°C
依拉斯汀	B1524-03	10mg	-20°C
依拉斯汀	B1524-04	25mg	-20°C
操作手册	1	1	常温

文件下载	文件内容	资源说明
	1524-依拉斯汀	操作手册
	1524-依拉斯汀相关单页	宣传单页

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