Erastin得名于eradicator of RAS和小T（ST）抗原表达细胞，是一种铁死亡诱导剂。1 它能在体外诱导铁死亡，这种作用可被铁死亡抑制剂环吡酮胺、Trolox（货号10011659）、铁抑素-1（货号17729）、U-0126（货号70970）、环己酰亚胺（货号14126）和β-巯基乙醇阻断。在HT-1080纤维肉瘤细胞和Calu-1肺癌细胞中，5μM的Erastin可通过xc⁻胱氨酸-谷氨酸转运系统抑制胱氨酸摄取，并在酶偶联荧光测定中抑制谷氨酸释放（半数有效浓度=1.2μM）。它还能选择性诱导表达SV40小T癌蛋白和致癌性Ras的细胞死亡（半数抑制浓度=1.25-5μg/ml）。2
Technical Information
Formal Name
2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone
CAS Number
571203-78-6
Molecular Formula
C30H31ClN4O4
Formula Weight
547.1
Purity
≥98%
Formulation
A crystalline solid
Solubility
DMF: 10 mg/mlDMSO: 5 mg/mlDMSO:PBS(pH 7.2) (1:2): 0.25 mg/ml
λmax
225, 276, 304 nm
SMILES
O=C1C2=CC=CC=C2N=C(N1C3=CC=CC=C3OCC)C(N4CCN(CC4)C(COC5=CC=C(C=C5)Cl)=O)C
InChi Code
InChI=1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3
InChi Key
BKQFRNYHFIQEKN-UHFFFAOYSA-N
参考文献：
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