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UTP溶液

UTP溶液,UTP - Solution,Uridine 5'-triphosphate, Sodium salt,5'-三磷酸尿苷钠盐。更多视频请关注视频号【艾维缔】。哔哩哔哩【IVDSHOW】。抖音【军哥聊表观】。


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UTP溶液


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NU1013SOL

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  • For general laboratory use.

    Please centrifuge briefly before opening (volume ≤2 ml).

    Shipping: shipped on gel packs

    Storage Conditions: store at -20 °C

    Shelf Life: 12 months

    Molecular Formula: C9H15N2O15P3 (free acid)

    Molecular Weight: 484.14 g/mol (free acid)

    CAS#: 19817-92-6

    Purity: ≥ 99 % (HPLC)

    Form: clear aqueous solution

    Concentration: 100 mM ±2 %

    pH: 8.0 ±0.2 (22 °C)

    Spectroscopic Properties: λmax 262 nm, ε 9.8 L mmol-1 cm-1 (Tris-HCl pH 7.0)

    Applications:
    Activation of purinergic receptors[1,2,3,4]
    Cardioprotection against hypoxic damage[2]
    Enzyme kinetic parameters[5]
    Phosphorylation of EGF-receptor vie purinergic receptors[3]
    Stimulation of neurogenesis and dopaminergic neurons[6]

    Description:
    Ultrapure UTP supplied as clear aqueous solution.

    Specific Ligands:

    Enterovirus 71 3D RNA polymerase[7]

    Ligand for purinergic receptors:
    P2X1[4]
    P2Y2[7,8,9,10]
    P2Y4[8,10,11]
    P2Y6[8]

  • 产品组分

    内容

    型号

    规格

    储存温度

    UTP溶液

    NU1013SOL-01

    1ml(100mM)

    -20°C

    UTP溶液

    NU1013SOL-02

    100ml(100mM)

    -20°C

    操作手册

    1 1

    常温

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  • 注意事项

    保存建议 厂家推荐蓝冰运输。当您收到产品后,按照说明书建议保存于-20°C。

     

  • FAQ

  • Selected References:
    [1] Raqeeb et al. (2011) Purinergic P2Y2 receptors mediate rapid Ca2+ mobilization, membrane hyperpolarization and nitric oxide production in human vascular endothelial cells. Cell Calcium 49:240.
    [2] Golan et al. (2011) Extracellular nucleotide derivatives protect cardiomyocytes against hypoxic stress. Biochemical Pharmacology 81:1219.
    [3] Boucher et al. (2011) Distinct activation of epidermal growth factor receptor by UTP contributes to epithelial cell wound repair. American Journal Pathology 178:1092.
    [4] Sugihara et al. (2011) Dual signaling pathway of arterial constriction by extracellular uridine-5-triphosphate in the rat. J. Pharmacological Sciences (Japan) 115:293.
    [5] Ma et al. (2011) Molecular cloning and analysis of the UDP-glucose pyrophosphorylase in Streptococcus equi subsp. Zooepidemicus. Molecular Biology Reports 38:2751.
    [6] Delic et al. (2011) Nucleotides affect neurogenesis and dopaminergic differentiation of mouse fetal midbrain-derived neural precursor cells. Puronergic Signalling 6:417.
    [7] Jiang et al. (2011) Biochemical characterization of enterovirus 71 3D RNA polymerase. Biochim. Biophys. Acta, Gene Regulatory Mechanisms 1809:211.
    [8] Pendergast et al. (2001) Synthesis and P2Y receptor activity of a series of uridine dinucleoside 5'-polyphosphates. Bioorg. Med. Chem. Lett. 11 (2):157.
    [9] Shaver et al. (1997) 4-substituted uridine 5'-triphosphates as agonists of the P2Y2 purinergic receptor. Nucleosides and Nucleotides 16 (7):1099.
    [10] Kim et al. (2002) Methanocarba modification of uracil and adenine nucleotides: High potency of northern ring conformation at P2Y1, P2Y2, P2Y4 and P2Y11 but not P2Y6 receptors. J. Med. Chem. 45:208.
    [11] Nguyen et al. (1995) Cloning, expression, and chromosomal localization of human uridine nucleotide receptors. J. Biol. Chem. 270 (52):30845.

    Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement.

    Marleen Bérouti, Mirko Wagner, ..., Veit Hornung

    Cell  |  2025 Jun 25  |  40580950

    Y-switch: a spring-loaded synthetic gene switch for robust DNA/RNA signal amplification and detection.

    Krishna Gupta, Elisha Krieg

    Nucleic Acids Research  |  2024 Aug 16  |  39149901  

    In Vitro Transcribed mRNA Immunogenicity Induces Chemokine-Mediated Lymphocyte Recruitment and Can Be Gradually Tailored by Uridine Modification.

    Norman M Drzeniek, Nourhan Kahwaji, ..., Hans-Dieter Volk

    Advanced science (Weinheim, Baden-Wurttemb…  |  2024 Jun 05  |  38491873

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