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AP4A(AppppA)溶液

AP4A(AppppA)溶液,AP4A - Solution,P1-(5'-Adenosyl) P4-(5'-adenosyl) tetraphosphate, Sodium salt,P1-(5'-腺苷基) P4-(5'-腺苷基) 四磷酸钠盐。更多视频请关注视频号【艾维缔】。哔哩哔哩【IVDSHOW】。抖音【军哥聊表观】。


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AP4A(AppppA)溶液


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NU507

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  • For general laboratory use.

    Please centrifuge briefly before opening (volume ≤2 ml).

    Shipping: shipped on gel packs

    Storage Conditions: store at -20 °C
    Short term exposure (up to 1 week cumulative) to ambient temperature possible.

    Shelf Life: 12 months after date of delivery

    Molecular Formula: C20H28N10O19P4 (free acid)

    Molecular Weight: 836.39 g/mol (free acid)

    Exact Mass: 836.05 g/mol (free acid)

    CAS#: 5542-28-9

    Purity: ≥ 95 % (HPLC)

    Form: solution in water

    Color: colorless to slightly yellow

    Concentration: 10 mM - 11 mM

    pH: 7.5 ±0.5

    Spectroscopic Properties: λmax 259 nm, ε 27.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)

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    内容

    型号

    规格

    储存温度

    AP4A(AppppA)溶液

    NU507-01

    100ul(10mM)

    -20°C

    AP4A(AppppA)溶液

    NU507-02

    500ul(10mM)

    -20°C

    操作手册

    1 1

    常温

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  • 注意事项

    保存建议 厂家推荐蓝冰运输。当您收到产品后,按照说明书建议保存于-20°C。

     

  • FAQ

  • Selected References:
    Reiser et al. (1999) Nucleotide radiolabels as tools for studying P2Y receptors in membranes from brain and lung tissue.Prog. Brain Res. 129:45.
    Safrany et al. (2007) Characterisation of a bis (5'-nucleosyl)-tetraphosphatase (asymmetrical) from Drosophila melanogasterInt. J. Biochem. Cell Biol. 39 (5):943.
    Gross et al. (2006) Nucleotide-binding domains of Cystic Fibrosis Transmembrane Conductance Regulator, an ABC Transporter, Catalyze Adenylate Kinase Activity but not ATP Hydrolysis. J. Biol. Chem. 281 (7):4058.
    Leslie et al. (2002) Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases. BMC Biochemistry 3:20.
    Campbell et al. (1999) Characterization of P1,P4-diadenosine 5'-tetraphosphate binding on bovine aortic endothelial cells. Arch. Biochem. Biophys. 364:280.
    Vartanian et al. (1999) Ap4A induces apoptosis in human cultured cells. FEBS Lett. 456:175.
    Brevet et al. (1985) Variation of Ap4A and other dinucleoside polyphosphates in stressed Drosophila cells. J. Biol. Chem. 260:15566.
    Guedon et al. (1985) Effect of diadenosine tetraphosphate microinjection on heat shock protein synthesis in Xenopus laevis oocytes. EMBO J. 4:3743.
    Guranowski et al. (1985) Phosphorolytic cleavage of diadenosine 5',5'''-P1,P4-tetraphosphate. Properties of homogeneous diadenosine 5',5'''-P1,P4-tetraphosphate alpha, beta-phosphorylase from Saccharomyces cerevisiae. J. Biol. Chem. 260:3542.
    Bochner et al. (1984) AppppA and related adenylylated nucleotides are synthesized as a consequence of oxidation stress. Cell 37 (1):225.
    Guranowski et al. (1983) Catabolism of diadenosine 5',5'-P1,P4-tetraphosphate in procaryotes. Purification and properties of diadenosine 5',5'-P1,P4-tetraphosphate (symmetrical) pyrophosphohydrolase from Escherichia coli K12. J. Biol. Chem. 258:14784.
    Jakubowski et al. (1983) Enzymes hydrolyzing ApppA and/or AppppA in higher plants. Purification and some properties of diadenosine triphosphatase, diadenosine tetraphosphatase, and phosphodiesterase from yellow lupin (Lupinus luteus) seeds. J. Biol. Chem. 258:9982.
    Giammarinaro et al. (2022) Diadenosine tetraphosphate regulates biosynthesis of GTP in Bacillus subtilis. Nat Microbiol 7:1442
    Young et al. (2024) From dusty shelves toward the spotlight: growing evidence for Ap4A as an alarmone in maintaining RNA stability and proteostasis. Current Opinion in Microbiology 81:102536.
    Zegarra et al. (2023) The mysterious diadenosine tetraphosphate (AP4A). microLife 4: doi.org/10.1093/femsml/uqad016.

    Systematic P2Y receptor survey identifies P2Y11 as modulator of immune responses and virus replication in macrophages.

    Line Lykke Andersen, Yiqi Huang, ..., Andreas Pichlmair

    The EMBO journal  |  2023 Dec 05  |  37881155

    Formation of the Alarmones Diadenosine Triphosphate and Tetraphosphate by Ubiquitin- and Ubiquitin-like-Activating Enzymes.

    Kathrin H Götz, Martin Mex, ..., Andreas Marx

    Cell chemical biology  |  2020 Aug 27  |  31492597  

    Formation of the Alarmones Diadenosine Triphosphate and Tetraphosphate by Ubiquitin- and Ubiquitin-like-Activating Enzymes.

    Kathrin H Götz, Martin Mex, ..., Andreas Marx

    Cell chemical biology  |  2020 Aug 27  |  31492597 

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