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寡霉素A是异构体中的主要类似物，是线粒体F1FO ATP合酶的抑制剂，可诱导多种细胞类型凋亡（平均GI50=270 nM）。1、2、3寡霉素A具有抗真菌、抗肿瘤和杀线虫活性，但在水和其他生物相容性溶剂中的溶解度较差，这限制了其临床应用。4
Technical Information
Formal Name
(1S,2'R,4E,5'R,6R,6'S,7S,8R,10S,11S,12R,14S,15R,16S,18E,20E,22S,25R,28R,29S)-
22- ethyl- 3',4',5',6'- tetrahydro- 7,11,14,15- tetrahydroxy- 6'- [(1Z)- 2- hydroxy- 1- propen- 1- yl]- 5',6,8,10,12,14,16,28,29- nonamethyl- spiro[2,26- dioxabicyclo[23.3.1]nonacosa- 4,18,20- triene- 27,2'- [2H]pyran]- 3,9,13- trione CAS Number
579-13-5
Synonyms
- MCH 32
Molecular Formula
C45H74O11
Formula Weight
791.1
Purity
≥95%
Formulation
A crystalline solid
Solubility
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
λmax
225 nm
SMILES
O=C([C@H](C)[C@@H](O)[C@H](C)/C=C/1)[C@@H](C)[C@H](O)[C@@H](C)C([C@](O)(C)[C@H](O)[C@@H](C)C/C=C/C=C/[C@](CC)([H])CC[C@]2([H])[C@H](C)[C@]([C@@H](C)[C@]3(CC[C@@H](C)[C@](C[C@@H](O)C)([H])O3)O2)([H])OC1=O)=O
InChi Code
InChI=1S/C45H74O11/c1-12-34-17-15-13-14-16-27(4)42(51)44(11,53)43(52)32(9)40(50)31(8)39(49)30(7)38(48)26(3)18-21-37(47)54-41-29(6)35(20-19-34)55-45(33(41)10)23-22-25(2)36(56-45)24-28(5)46/h13-15,17-18,21,25-36,38,40-42,46,48,50-51,53H,12,16,19-20,22-
InChi Key
MNULEGDCPYONBU-WMBHJXFZSA-N
Origin
Bacterium/Streptomyces sp.
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产品组分
内容
型号
规格 储存温度
寡霉素A 11342-01 1mg -20°C 寡霉素A 11342-02 5mg -20°C 寡霉素A 11342-03 10mg -20°C 寡霉素A 11342-04 25mg -20°C 操作手册
1 1 常温
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注意事项
保存建议 厂家推荐蓝冰运输。当您收到产品后，按照说明书建议保存于-20°C。 -
FAQ
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Product Description References
1. Salomon, A.R., Voehringer, D.W., Herzenberg, L.A., et al. Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-
ATPase. Chem. Biol. 8, 71-80 (2001). 2. Shin, Y.K., Yoo, B.C., Chang, H.J., et al. Down-
regulation of mitochondrial F1F0- ATP synthase in human colon cancer cells with induced 5- fluorouracil resistance. Cancer Res. 65(8), 3162-3170 (2005). 3. Laatsch, H., Kellner, M., Wolf, G., et al. Oligomycin F, a new immunosuppressive homologue of oligomycin A. J. Antibiot. (Tokyo) 46(9), 1334-1341 (1993).
4. Zu, Y., Zhao, Q., Zhao, X., et al. Process optimization of the preparation of oligomycin-
loaded folate- conjugated chitosan nanoparticles as a tumor- targeted drug delivery system using a two- level factorial design method. Int. J. Nanomedicine 6, 3429-3441 (2011). Product Citations
Kremer, D.M., Nelson, B.S., Lin, L., et al. GOT1 inhibition primes pancreatic cancer for ferroptosis through the autophagic release of labile iron. bioRxiv (2020).
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