维利帕尼

维利帕尼，Veliparib，ABT-888，PARP抑制剂。更多视频请关注视频号【艾维缔】。哔哩哔哩【IVDSHOW】。抖音【军哥聊表观】。

关键词

维利帕尼

所属分类

抑制剂

目录号

A3002

获取报价

IC50和靶点

生物活性描述	Veliparib (ABT-888)是一个有效的PARP1和PARP2抑制剂，Ki值分别为5.2 nM和2.9 nM。.
靶点	PARP1	PARP2
生物活性数据	5.2 nM (Ki)	2.9 nM (Ki)

参考文献：
1. Shivaani Kummar, Robert Kinders, Martin E. Gutierrez, Larry Rubinstein, Ralph E. Parchment, Lawrence R. Phillips, Jiuping Ji, Anne Monks, Jennifer A. Low, Alice Chen, Anthony J. Murgo, Jerry Collins, Seth M. Steinberg, Helen Eliopoulos, Vincent L. Giranda, Gary Gordon, Lee Helman, Robert Wiltrout, Joseph E. Tomaszewski and James H. Doroshow. Phase 0 Clinical Trial of the Poly (ADP-Ribose) Polymerase Inhibitor ABT-888 in Patients With Advanced Malignancies. Journal of Clinical Oncology. 2009; 27(16): 2705 – 11.
2. Xiaofeng Li, Juergen Delzer, Richard Voorman, Sonia M. de Morais and Yanbin Lao. Disposition and Drug-Drug Interaction Potential of Veliparib (ABT-888), a Novel and Potent Inhibitor of Poly (ADP-ribose) Polymerase. DRUG METABOLISM AND DISPOSITION. 2011; 39(7): 1161 – 69.
3. E. Vilar Sanchez, A. Chow, L. Raskin, M. D. Iniesta, B. Mukherjee and S. B. Gruber. Preclinical testing of the PARP inhibitor ABT-888 in microsatellite instable colorectal cancer. Journal of Clinical Oncology. 2009; 27(15S): 11028A.

产品组分

内容	型号	规格	储存温度
维利帕尼	A3002-01	5mg	-20°C
维利帕尼	A3002-02	10mg	-20°C
维利帕尼	A3002-03	50mg	-20°C
维利帕尼	A3002-04	200mg	-20°C
操作手册	1	1	常温

文件资源

营销中心
注意事项

保存建议厂家推荐蓝冰运输。当您收到产品后，按照说明书建议保存于-20°C。
FAQ
1. Masato Mashimo, Momoko Kita, et al. "Tankyrase Regulates Neurite Outgrowth through Poly (ADP-ribosyl) ation-Dependent Activation of β-Catenin Signaling." Int J Mol Sci. 2022 Mar 4;23(5):2834. PMID: 35269974

2. Kouzoukas DE, Schreiber JA, et al. "PARP inhibition blocks alcohol-induced neurodegeneration and neuroinflammatory cytosolic phospholipase A2 elevations." Neurochem Int. 2019 Jun 25:104497. PMID: 31251945

3. Poh W, Dilley RL, et al. "BRCA1 Promoter Methylation Is Linked to Defective Homologous Recombination Repair and Elevated miR-155 to Disrupt Myeloid Differentiation in Myeloidb Malignancies." Clin Cancer Res. 2019 Jan 28. PMID: 30692098

4. Versano Z, Shany E, et al. "MutT homolog 1 counteracts the effect of anti-neoplastic treatments in adult and pediatric glioblastoma cells." Oncotarget. 2018 Jun 8;9(44):27547-27563. PMID: 29938005

5. Gao Y, Li C, et al. "SSRP1 Cooperates with PARP and XRCC1 to Facilitate Single-Strand DNA Break Repair by Chromatin Priming." Cancer Res. 2017 May 15;77(10):2674-2685.

PMID: 28416484

6. Wang X, Sekine Y, et al."Inhibition of Poly-ADP-Ribosylation Fails to Increase Axonal Regeneration or Improve Functional Recovery after Adult Mammalian CNS Injury." eNeuro. 2016 Dec 26;3(6). PMID: 28032120

7. Yalon M, Tuval-Kochen L, et al. "Overcoming Resistance of Cancer Cells to PARP-1 Inhibitors with Three Different Drug Combinations." PLoS One. 2016 May 19;11(5):e0155711. PMID: 27196668

8. Nassour J, Martien S, et al."Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells." Nat Commun. 2016 Jan 29;7:10399. PMID: 26822533

物理外观	A solid
CAS号	912444-00-9
分子式	C₁₃H₁₆N₄O
分子量	244.3
小分子别名	Veliparib
化学名称	1-[3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one
溶解度	insoluble in H2O; ≥10.6 mg/mL in EtOH with ultrasonic; ≥6.11 mg/mL in DMSO
SMILES	CC1(c([nH]c2ccc3)nc2c3C(N)=O)NCCC1
存储条件	-20°C
运输条件	蓝冰
SDF文件	Download SDF

文件下载	文件内容	资源说明
	A3002-维利帕尼	操作手册
	A3002-维利帕尼相关单页	宣传单页

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维利帕尼

IC50和靶点

产品组分

文件资源

营销中心

注意事项

FAQ