毒胡萝卜素

毒胡萝卜素，Thapsigargin，肌质网状Ca2+-ATP酶抑制剂。更多视频请关注视频号【艾维缔】。哔哩哔哩【IVDSHOW】。抖音【军哥聊表观】。

关键词

毒胡萝卜素

所属分类

抑制剂

目录号

B6614

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Thapsigargin is an inhibitor of microsomal Ca²⁺-ATPase, Thapsigargin inhibits the carbachol-evoked [Ca²⁺]i-transients with IC50 value of 0.353 nM [1].

Thapsigargin may induce cell apoptosis in MH7A cells in a time- and dose-dependent manner, and the percentages of cell death reached 44.6% at thapsigargin concentration of 1 μM treated for 4 days compared to the control. The protein and mRNA levels of cyclin D1 decreased gradually with the increasing of thapsigargin concentration and treatment times [2].

In regards to vivo results, tunicamycin is superior in not only inducing ER stress but also recapturing the metabolic alterations associated with ER stress [3].

物理外观	A crystalline solid
CAS号	67526-95-8
分子式	C₃₄H₅₀O₁₂
分子量	650.76
化学名称	(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetoxy-4-(butyryloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-(((Z)-2-methylbut-2-enoyl)oxy)-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-7-yl octanoate
溶解度	≥39.2 mg/mL in DMSO; ≥24.8 mg/mL in EtOH; ≥4.12 mg/mL in H2O with ultrasonic
SMILES	O[C@@]([C@H]1OC(CCC)=O)([C@]2(C)O)[C@H](C([C@H]([C@@H]3OC(CCCCCCC)=O)[C@@](C1)(C)OC(C)=O)=C(C)[C@@H]3OC(/C(C)=C\C)=O)OC2=O
存储条件	-20°C干燥
运输条件	蓝冰
SDF文件	Download SDF

IC50和靶点

生物活性描述

Thapsigargin 是一种微粒体 Ca2+-ATP 酶抑制剂和内质网应激诱导剂。

产品组分

内容	型号	规格	储存温度
毒胡萝卜素	B6614-01	1mg	-20°C
毒胡萝卜素	B6614-02	5mg	-20°C
毒胡萝卜素	B6614-03	10mg	-20°C
操作手册	1	1	常温

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保存建议厂家推荐蓝冰运输。当您收到产品后，按照说明书建议保存于-20°C。
FAQ
References:

[1]. Garavito-Aguilar ZV, et al. Differential thapsigargin-sensitivities and interaction of Ca2+ stores in human SH-SY5Y neuroblastoma cells. Brain Res. 2004 Jun 18;1011(2):177-86.

[2]. Wang H, et al. Effects of thapsigargin on the proliferation and survival of human rheumatoid arthritis synovialcells. ScientificWorldJournal. 2014 Feb 9;2014:605416.

[3]. Abdullahi A, et al. Modeling Acute ER Stress in Vivo and in Vitro. Shock. 2017 Apr;47(4):506-513.