牛磺熊去氧胆酸

牛磺熊去氧胆酸，Tauroursodeoxycholic Acid，线粒体稳定剂，抗凋亡剂。更多视频请关注视频号【艾维缔】。哔哩哔哩【IVDSHOW】。抖音【军哥聊表观】。

关键词

牛磺熊去氧胆酸

所属分类

抑制剂

目录号

C3233

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文献追踪

Tauroursodeoxycholic acid (TUDCA) is a taurine conjugate product of ursodeoxycholic acid, which can be used as a mitochondrial stabilizer and anti-apoptotic agent.

In endoplasmic reticulum stress conditions, TUDCA treatment of MSCs (mesenchymal stem cells) reduces the activation of ER stress-associated proteins and inhibits the dissociation between GRP78 and PERK, thereby reducing endoplasmic reticulum stress Mediated cell death.

In a murine hindlimb ischemia model, TUDCA-treated mesenchymal stem cells (MSCs) transplantation can increase blood perfusion ratio, promote blood vessel formation, and improve the survival rate of transplanted cell more than untreated MSC transplantation does.

物理外观	Solid
CAS号	14605-22-2
分子式	C₂₆H₄₅NO₆S
分子量	499.7
小分子别名	Tauroursodeoxycholate
化学名称	2-((R)-4-((3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)ethanesulfonic acid
溶解度	≥50 mg/mL in DMSO; ≥4.8 mg/mL in H2O with ultrasonic; ≥55.7 mg/mL in EtOH
SMILES	C[C@H](CCC(NCCS(O)(=O)=O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
存储条件	-20°C
运输条件	蓝冰
SDF文件	Download SDF

IC50和靶点

生物活性描述

牛磺脱氧胆酸（Tauroursodeoxycholate）是一种内质网（ER）应激抑制剂。Tauroursodeoxycholate 能明显降低 caspase-3 和 caspase-12 等凋亡分子的表达。牛磺脱氧胆酸还能抑制 ERK。

产品组分

内容	型号	规格	储存温度
牛磺熊去氧胆酸	C3233-01	500mg	-20°C
牛磺熊去氧胆酸	C3233-02	1g	-20°C
牛磺熊去氧胆酸	C3233-03	5g	-20°C
操作手册	1	1	常温

文件资源

营销中心
注意事项

保存建议厂家推荐蓝冰运输。当您收到产品后，按照说明书建议保存于-20°C。
FAQ
Reference:

[1]. Yoon Y M, Lee J H, Yun S P, et al. Tauroursodeoxycholic acid reduces ER stress by regulating of Akt-dependent cellular prion protein. Scientific Reports, 2016, 6(1): 39838.

1. Hui Yang, Kang Ou-Yang, et al. "Nitrite Induces Hepatic Glucose and Lipid Metabolism Disorders in Zebrafish Through Mitochondrial Dysfunction and Ers Response." Aquat Toxicol. 2024 Aug:273:107015 PMID: 38996482

2. Kunhao Ren, Linzhi Dai, et al. "Neuritin attenuates neuroinflammation and apoptosis in early brain injury after subarachnoid hemorrhage via endoplasmic reticulum stress-related inflammatory pathways." Research Square. 26 Jun, 2024