醛固酮

醛固酮，Aldosterone，主要的盐皮质激素，控制钠和钾平衡。更多视频请关注视频号【艾维缔】。哔哩哔哩【IVDSHOW】。抖音【军哥聊表观】。

关键词

LEXSY盐酸四环素

所属分类

IVDEpi

目录号

C4453

获取报价

猜你喜欢

产品描述
产品组分
文件资源
营销中心
注意事项
FAQ
文献追踪

Aldosterone is a steroid hormone secreted by the adrenal cortex and is the principle mineralocorticoid controlling sodium and potassium balance[1].

In vascular smooth muscle cells, aldosterone inhibits nitrite production in a dose-dependent manner, which is induced by interleukin-1β (IL-1β). Aldosterone inhibits mRNA expression of NO synthase. And reduce the accumulation of nitric oxide synthase protein. In conclusion, aldosterone inhibits NO synthesis in vascular smooth muscle cells under IL-1β stimulated conditions[2].

Aldosterone (0.72 mg/kg/day, 14 days) caused a slight increase in blood pressure in male mice (14 mmHg). Aldosterone can also increase the production of superoxide in the cerebral arteries of mice and promote mRNA expression of chemokine (C-C motif) ligand 7 (CCL7), CCL8 and IL-1β in the brain[3].

References:

[1]. Agarwal M K, Mirshahi M. General overview of mineralocorticoid hormone action. Pharmacology & Therapeutics, 2000, 84(3): 273-326.

[2]. Ikeda U, et al. Aldosterone inhibits nitric oxide synthesis in rat vascular smooth muscle cells induced by interleukin-1 beta. Eur J Pharmacol. 1995, 290(2): 69-73.

[3]. Dinh Q N, et al. Aldosterone-induced oxidative stress and inflammation in the brain are mediated by the endothelial cell mineralocorticoid receptor. Brain Res, 2016, 1637: 146-153.

物理外观	A crystalline solid
CAS号	52-39-1
分子式	C₂₁H₂₈O₅
分子量	360.44
化学名称	(8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-13-carbaldehyde
溶解度	≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
SMILES	O=C1CC[C@]2(C(CC[C@@]3([C@@]2([C@H](C[C@]4([C@]3(CC[C@@H]4C(CO)=O)[H])C([H])=O)O)[H])[H])=C1)C
存储条件	-20°C
运输条件	蓝冰
SDF文件	Download SDF

IC50和靶点

生物活性描述

醛固酮是主要的矿皮质激素。醛固酮是肾上腺皮质的肾小球膜在肾素-血管紧张素系统激活或饮食中摄入高钾时合成和分泌的。

产品组分

内容	型号	规格	储存温度
醛固酮	C4453-01	500ug	-20 °C
醛固酮	C4453-02	1mg	-20 °C
醛固酮	C4453-03	5mg	-20 °C
醛固酮	C4453-04	10mg	-20 °C
操作手册	1	1	常温

文件资源

营销中心
注意事项

保存建议厂家推荐蓝冰运输。当您收到产品后，按照说明书建议保存于-20°C。
FAQ
1. Bo Pang, Yijiang Bai, et al. "Circadian rhythm disruptions exacerbate inner ear damage in a murine endolymphatic hydrops model." FASEB J. 2025 Jan15;39(1):e70310 PMID: 39781606

2. Xuhong Fan, Zhenyu Zhao, et al. "Mineralocorticoid receptor agonist aldosterone rescues hippocampal neural stem cell proliferation defects and improves postoperative cognitive function in aged mice." World J Biol Psychiatry. 2022 Jun 14;1-13 PMID: 35615969

3. Meiling He, Tiantian Zhou, et al. "The protease corin regulates electrolyte homeostasis in eccrine sweat glands." PLoS Biol. 2021 Feb 16;19(2):e3001090. PMID:33591965