胆甾醇半琥珀酸酯

胆甾醇半琥珀酸酯，Cholesteryl Hemisuccinate，是一种经常使用在极性溶液中具有高溶解度的胆固醇类似物，具有保肝、抗癌和抑制肿瘤生长的作用。更多视频请关注视频号【艾维缔】。哔哩哔哩【IVDSHOW】。抖音【军哥聊表观】。

关键词

胆甾醇半琥珀酸酯

所属分类

抑制剂

目录号

T67509

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文献追踪

胆甾醇半琥珀酸酯是一种经常使用在极性溶液中具有高溶解度的胆固醇类似物，具有保肝、抗癌和抑制肿瘤生长的作用。Cholesteryl Hemisuccinate 抑制对乙酰氨基酚的肝毒性，并防止 AAP 诱导的肝细胞凋亡和坏死。Cholesteryl Hemisuccinate 抑制 DNA 聚合酶和 DNA 拓扑异构酶，从而抑制 DNA 复制和修复以及细胞分裂。

生物活性

产品描述	Cholesteryl Hemisuccinate (Cholesterol hydrogen succinate) is a highly soluble cholesterol analogue often used in polar solutions for its hepatoprotective, anticancer and tumour growth inhibiting properties. Cholesteryl Hemisuccinate inhibits the hepatotoxicity of acetaminophen and prevents AAP-induced apoptosis and necrosis in hepatocytes. Cholesteryl Hemisuccinate inhibits DNA polymerase and DNA topoisomerase, thereby inhibiting DNA replication and repair as well as cell division.
体外活性	Cholesteryl Hemisuccinate (0-1000 μM) 抑制了MCF-7和MCF-10A细胞的生长。[3]
体内活性	Cholesteryl Hemisuccinate（100 mg/kg；ip；AAP前单次给药）在ICR小鼠（CD-1）中消除了AAP引起的凋亡和坏死，用于组织学和生化诊断。[1]
别名	胆甾醇半琥珀酸酯, Cholesterol hydrogen succinate

化学信息

分子量	486.73
分子式	C₃₁H₅₀O₄
CAS No.	1510-21-0
Smiles	[H][C@@]12CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@H](CC[C@]12C)OC(=O)CCC(O)=O
密度	1.06 g/cm3 (Predicted)

产品组分

内容	型号	规格	储存温度
胆甾醇半琥珀酸酯	T67509-01	50mg	-20°C
胆甾醇半琥珀酸酯	T67509-02	100mg	-20°C
胆甾醇半琥珀酸酯	T67509-03	500mg	-20°C
胆甾醇半琥珀酸酯	T67509-04	1g	-20°C
胆甾醇半琥珀酸酯	T67509-05	5g	-20°C
操作手册	1	1	常温

文件资源

营销中心
注意事项

保存建议厂家推荐蓝冰运输。当您收到产品后，按照说明书建议保存于-20°C。
FAQ
1.Ray SD, et al. Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment. J Pharmacol Exp Ther. 1996 ; 279(3):1470-1483.

2.Varshosaz J, et al. Folated synperonic-cholesteryl hemisuccinate polymeric micelles for the targeted delivery of docetaxel in melanoma. Biomed Res Int. 2015 ; 2015:746093.

3.Djuric Z, et al. Growth inhibition of MCF-7 and MCF-10A human breast cells by alpha-tocopheryl hemisuccinate, cholesteryl hemisuccinate and their ether analogs. Cancer Lett. 1997 ; 111(1-2):133-139.

4.Pajor L, et al. Cholesteryl hemisuccinate's inductive effect on membrane rigidization regarding both, its remodelling of the cells' surface receptor pattern and its decreasing the natural killer susceptibility of K-562 cells. Acta Biol Hung. 1991 ; 42(4):371-383.

5.Yamamoto Y, et al. Relationship between Thylakoid Membrane Fluidity and the Functioning of Pea Chloroplasts : EFFECT OF CHOLESTERYL HEMISUCCINATE. Plant Physiol. 1981 ; 67(6):1069-1072.