红藻氨酸

红藻氨酸，3-Azido-D-alanine hydrochloride ，是一种类似于兴奋毒性神经递质谷氨酸的物质。更多视频请关注视频号【艾维缔】。哔哩哔哩【IVDSHOW】。抖音【军哥聊表观】。

关键词

红藻氨酸

所属分类

抑制剂

目录号

GC16667

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Kainic acid (KA)是一种类似于兴奋毒性神经递质谷氨酸的物质。

Kainic acid (KA), is an analog of the excitotoxic neurotransmitter glutamate. Kainic acid induces seizures[1-3].

Kainic acid(200 µM; 45 min) exposure induced caspase and calpain activation in neuronal cultures[4]. Kainic acid(5 µM) induces seizure-like activity in cortical human neurons[5]. Treatments with KA(1-100 µM) resulted in a significant decrease in cell viability in primary cultures of hippocampal neurons [6].

KA-induced(10 mg/kg;i.p) excitotoxicity led to sustained hyperphosphorylation of tau in MAPT transgenic (Tg) mice. This can lead to memory deficits[7]. After 1.0 µg of Kainic acid was injected into the hippocampus of young mice at 6, 7 and 9 days of age, pyramidal cells died significantly [8]. Injection of Kainic acid(70 µl/min; 16 mg/kg;i.v) through the tail vein of a mouse reliably and rapidly induces status epilepticus (SE) which remits spontaneously and leads to the development of temporal lobe epilepsy (TLE) in a subset of mice[9].

References:
[1]. LÉvesque M, Avoli M. The kainic acid model of temporal lobe epilepsy. Neurosci Biobehav Rev. 2013 Dec;37(10 Pt 2):2887-99. doi: 10.1016/j.neubiorev.2013.10.011. Epub 2013 Oct 30. PMID: 24184743; PMCID: PMC4878897.
[2]. Ben-Ari Y, Cossart R. Kainate, a double agent that generates seizures: two decades of progress. Trends Neurosci. 2000 Nov;23(11):580-7. doi: 10.1016/s0166-2236(00)01659-3. PMID: 11074268.
[3]. Barker-Haliski M, White HS. Glutamatergic Mechanisms Associated with Seizures and Epilepsy. Cold Spring Harb Perspect Med. 2015 Jun 22;5(8):a022863. doi: 10.1101/cshperspect.a022863. PMID: 26101204; PMCID: PMC4526718.
[4]. Meade AJ, Meloni BP, et,al. AP-1 inhibitory peptides attenuate in vitro cortical neuronal cell death induced by kainic acid. Brain Res. 2010 Nov 11;1360:8-16. doi: 10.1016/j.brainres.2010.09.007. Epub 2010 Sep 15. PMID: 20833150.
[5]. Mzezewa R, Lotila J, et,al. A kainic acid-induced seizure model in human pluripotent stem cell-derived cortical neurons for studying the role of IL-6 in the functional activity. Stem Cell Res. 2022 Apr;60:102665. doi: 10.1016/j.scr.2022.102665. Epub 2022 Jan 17. PMID: 35091307.
[6]. RodrÍguez-ChÁvez V, Flores-Soto E, et,al. Prolactin reduces the kainic acid-induced increase in intracellular Ca2+ concentration, leading to neuroprotection of hippocampal neurons. Neurosci Lett. 2023 Jul 27;810:137344. doi: 10.1016/j.neulet.2023.137344. Epub 2023 Jun 13. PMID: 37315731.
[7]. Zheng XY, Lv YD, et,al. Kainic acid hyperphosphorylates tau via inflammasome activation in MAPT transgenic mice. Aging (Albany NY). 2019 Dec 2;11(23):10923-10938. doi: 10.18632/aging.102495. Epub 2019 Dec 2. PMID: 31789603; PMCID: PMC6932880.
[8]. Cook TM, Crutcher KA. Intrahippocampal injection of kainic acid produces significant pyramidal cell loss in neonatal rats. Neuroscience. 1986 May;18(1):79-92. doi: 10.1016/0306-4522(86)90180-6. PMID: 3736859.
[9]. Drysdale ND, Matthews E, et,al. Intravenous kainic acid induces status epilepticus and late onset seizures in mice. Epilepsy Res. 2021 Dec;178:106816. doi: 10.1016/j.eplepsyres.2021.106816. Epub 2021 Nov 14. PMID: 34808484; PMCID: PMC8657370.

Kainic acid (KA)是一种类似于兴奋毒性神经递质谷氨酸的物质。Kainic acid诱导癫痫发作[1-3]。

Kainic acid(200 µM; 45 min)在神经元中诱导caspase和钙蛋白酶calpain激活[4]。Kainic acid(5 µM)诱导人类皮层神经元的癫痫样活动[5]。Kainic acid (1-100 µM)处理导致海马神经元原代培养细胞活力显著降低[6]。

Kainic acid (10 mg/kg;i.p) 诱导的兴奋性毒性导致MAPT转基因(Tg)小鼠的tau持续过度磷酸化,这会导致记忆力减退[7]。在6、7、9日龄幼鼠海马中注射1.0µg Kainic acid后,锥体细胞明显死亡[8]。Kainic acid(70 µl/min;16 mg/kg; iv)通过小鼠尾静脉可快速地诱导癫痫持续状态(SE),并导致一部分小鼠发生颞叶癫痫(TLE)[9]。
关键词:
- 红藻氨酸

产品组分

内容	型号	规格	储存温度
红藻氨酸	GC16667-01	1mg	-20°C
红藻氨酸	GC16667-02	5mg	-20°C
红藻氨酸	GC16667-03	10mg	-20°C
红藻氨酸	GC16667-04	25mg	-20°C
红藻氨酸	GC16667-05	10mM in 1mL DMSO	-20°C
操作手册	1	1	常温