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GGTase-II（香叶基香叶基转移酶-II）催化香叶基香叶基基团转移至Rab蛋白的两个C端半胱氨酸上。该酶由α和β异二聚体组成（分别为50千道尔顿和38千道尔顿），其催化活性需要Rab护送蛋白参与。研究表明，GGTase-II对香叶基香叶基焦磷酸（解离常数Kd = 8纳摩尔）的亲和力高于法尼基焦磷酸（解离常数Kd = 60纳摩尔）。与法尼基转移酶（FTase）和GGTase-I一样，RabGGT以异二聚体形式发挥作用。其α亚基与CaaX异戊烯转移酶的α亚基有27%的同源性，但包含额外的结构域；β亚基与FTase的β亚基则有29%的同源性。RabGGT的蛋白质底物具有异质性的C端，通常包含两个半胱氨酸残基（CXC），且这两个残基均会被香叶基香叶基基团修饰。与CaaX异戊烯转移酶不同，RabGGT需要被称为REPs的特定辅助蛋白来介导其与靶标的相互作用。已有研究发现，某些法尼基转移酶抑制剂（FTIs）可抑制RabGGT的活性，并在秀丽隐杆线虫中诱导p53非依赖性凋亡。
For general laboratory use.
Please centrifuge briefly before opening (volume ≤2 ml).Shipping: shipped on dry ice
Storage Conditions: store at -80 °C
avoid freeze/thaw cyclesShelf Life: 12 months
Molecular Weight: α: 50 kDa, β: 38 kDa
Accession number: Q08602 / Q08603
Purity: > 90 % (SDS-PAGE)
Form: liquid, supplied in 50 mM HEPES pH 7.4, 40 mM NaCl, 1 mM TCEP and 5 μM ZnCl2
Activity: 1 mol of enzyme will support conjugation of 2 mol of geranylgeranyl moieties to C-terminal cysteins of Rab7 GTPase in the presence of REP-1 in 2 minutes at 37°C
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产品组分
内容 型号
规格 储存温度
GGTase-II(RabGGTase) PR103-01 50ug -20°C GGTase-II(RabGGTase) PR103-02 100ug -20°C 操作手册
1 1 常温
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注意事项
保存建议 厂家推荐蓝冰运输。当您收到产品后，按照说明书建议保存于-20°C。 -
FAQ
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