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For general laboratory use.
Please centrifuge briefly before opening (volume ≤2 ml).Shipping: shipped on dry ice
Storage Conditions: store at -80 °C
avoid freeze/thaw cyclesShelf Life: 12 months
Purity: > 90 % (SDS-PAGE)
Form: liquid (Supplied in 25 mM HEPES pH 7.2, 40 mM NaCl and 5 mM DTT)
Activity: 1 pmol of REP-1 will mediate transfer of 2 pmol of geranylgeraniol by RabGGTase onto 1 pmol of Rab7 in 3 minutes.
Description:
C-terminal His-tagged REP-1 (Rab escort protein-1) binds to a wide range of RabGGTase with nanomolar affinities and supports the prenylation of RabGTPase mediated by RabGGTase. -
产品组分
内容 型号
规格 储存温度
组氨酸标签REP-1 PR105-01 50ug -20°C 组氨酸标签REP-1 PR105-02 100ug -20°C 操作手册
1 1 常温
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营销中心
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注意事项
保存建议 厂家推荐蓝冰运输。当您收到产品后，按照说明书建议保存于-20°C。 -
FAQ
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mRNA Delivery to the Retina restores REP1 Function in Choroideremia
Luisa de Lemos, Pedro Antas, ..., Miguel C. Seabra
Molecular Therapy Advances | 2026 May 01
NK cell dysfunction and interferon-γ production underlie autoinflammation in mevalonate kinase deficiency.
Marcia A Munoz, Iona S Schuster, ..., Michael J Rogers
Immunity | 2026 Apr 30 | 42066777
Loss of REP-1 in retinal pigment epithelial cells leads to impaired phagosome processing and altered lysosomal pathway function
Molecular Biology of the Cell | 2025 Aug 06
Reduced Retinal Pigment Epithelial Autophagy Due to Loss of Rab12 Prenylation in a Human iPSC-RPE Model of Choroideremia
Maide Ö. Raeker, Nirosha D. Perera, ..., Leila Maouche-Chretien
Cells | 2024 Jun 19 | 38920696
Evaluation of CRISPR/Cas9 exon-skipping vector for choroideremia using human induced pluripotent stem cell-derived RPE.
Toshiro Iwagawa, Hiroki Masumoto, ..., Sumiko Watanabe
The journal of gene medicine | 2023 Feb 13 | 36413603
Expression of Rab Prenylation Pathway Genes and Relation to Disease Progression in Choroideremia
Lewis E. Fry, Maria I. Patrício, ..., Robert E. MacLaren
Translational Vision Science & Technology | 2021 Jul 13 | 34254989
Inclusion of PF68 Surfactant Improves Stability of rAAV Titer when Passed through a Surgical Device Used in Retinal Gene Therapy
Maria I. Patrício, Christopher I. Cox, ..., Robert E. MacLaren
Molecular Therapy. Methods & Clinical Deve… | 2019 Nov 20 | 31890744
The Biological Activity of AAV Vectors for Choroideremia Gene Therapy Can Be Measured by In Vitro Prenylation of RAB6A
Maria I. Patrício, Alun R. Barnard, ..., Robert E. MacLaren
Molecular Therapy. Methods & Clinical Deve… | 2018 Mar 28 | 29707603
Analysis of protein prenylation in vitro and in vivo using functionalized phosphoisoprenoids.
Uyen T T Nguyen, Yaowen Wu, ..., Kirill Alexandrov
Current protocols in protein science | 2011 Feb 24 | 21104984
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