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肾型谷氨酰胺酶（GLS1）是一种磷酸激活的酰胺水解酶，可催化L-谷氨酰胺水解为L-谷氨酸和氨。GLS1主要在大脑和肾脏中表达，在肾脏谷氨酰胺分解代谢的主要途径中催化第一步反应。它在为代谢供能、合成大脑神经递质谷氨酸以及维持肾脏酸碱平衡方面发挥着关键作用。
GLS1 抑制剂筛选检测试剂盒旨在用于测定谷氨酰胺酶 1（GLS1）的水解酶活性，以满足筛选和特征分析的应用需求。
Assay Kit Format
Fluorogenic
Species
Human
Supplied As
The GLS1 assay kit comes in a convenient 96-well format, with purified GLS1, its substrates, the Coupling reagent, and GLS1 buffer for 100 enzyme reactions. In addition, the kit includes the GLS1 inhibitor CB-839 for use as a control inhibitor.
Materials Required But Not Supplied
- 0.5 M DTT in aqueous solution
- Adjustable micropipettor and sterile tips
- Fluorescent microplate reader capable of reading ⅄ excitation = 340 nm; ⅄ emission = 460 nm
Target(s)
GLS1
UniProt #
O94925
Stability
Stable at least 6 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival.
Instructions for Use
See assay kit data sheet for detailed protocol.
Shipping Temperature
-80°C
Warnings
Avoid freeze/thaw cycles.
Scientific Category
Metabolic
Regulatory Status
Research Use Only
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产品组分
内容 型号
规格 储存温度
GLS1抑制剂筛选检测试剂盒
79596-01 96次
-20°C GLS1抑制剂筛选检测试剂盒 79596-02 384次
-20°C 操作手册
1 1 常温
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注意事项
保存建议 厂家推荐蓝冰运输。当您收到产品后，按照说明书建议保存于-20°C。 -
FAQ
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References
1. Mates, J. M., et al. (2013). Glutaminase isoenzymes as key regulators in metabolic and oxidative stress against cancer. Current Molecular Medicine 13(4): 514-534.
2. Gross, Matthew I., et al. (2014). Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer. Molecular Cancer Therapeutics 13(4): 890-901.
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