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For general laboratory use.
Please centrifuge briefly before opening (volume ≤2 ml).Shipping: shipped on gel packs
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.Shelf Life: 12 months after date of delivery
Molecular Formula: C11H15N4O7PS (free acid)
Molecular Weight: 378.29 g/mol (free acid)
Exact Mass: 378.04 g/mol (free acid)
CAS#: 7021-52-5
Purity: ≥ 95 % (HPLC)
Form: solution in water
Concentration: 10 mM - 11 mM
pH: 7.5 ±0.5
Spectroscopic Properties: λmax 224/292 nm, ε 11.5/19.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Applications:
Catabolism by purine-5'-nucleotidase[1]
Transport by multidrug resistance proteins MRP4 and MRP5[2]
Strong inhibitor of purine synthesis de novo[3] -
产品组分
内容
型号
规格 储存温度
6-甲硫基肌苷一磷酸
NU1226-01 150ul(10mM)
-20°C 6-甲硫基肌苷一磷酸
NU1226-02 750ul(10mM)
-20°C 操作手册
1 1 常温
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营销中心
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注意事项
保存建议 厂家推荐蓝冰运输。当您收到产品后，按照说明书建议保存于-20°C。 -
FAQ
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Selected References:
[1] Brouwer et al. (2005) Role of 5'-nucleotidase in thiopurine metabolism:Enzyme kinetic profile and association with thio-GMP levels in patients with acute lymphoblastic leukemia during 6-mercaptopurine treatment. Clinica Chemica Acta 361:95.
[2] Wielinga et al. (2002) Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells. Molecular Pharmacology 62:1321.
[3] Stet et al. (1994) Decrease of S-adenosylmethionine synthesis by 6-mercaptopurine ribonucleoside in Molt F4 human malignant lymphoblasts. Biochemical J. 304:163.
Lavi et al. (1985) A rapid and sensitive high-performance liquid chromatographic assay for 6-mercaptopurine metabolites in red blood cells. Anal. Biochem. 144 (2):514.Metabolite glues as a means of purine sensing and chemotherapeutic response.
Samuel R Witus, Megan M Kober, ..., Michael Rapé
Nature | 2026 Jul 15 | 42457960
Metabolic glues as a means of purine sensing and chemotherapeutic response
Witus Samuel R., Kober Megan M., ..., Rapé Michael
bioRxiv | 2026 May 06
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