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For general laboratory use.
Please centrifuge briefly before opening (volume ≤2 ml).Shipping: shipped on gel packs
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.Shelf Life: 12 months after date of delivery
Molecular Formula: C10H13N4O7PS (free acid)
Molecular Weight: 364.26 g/mol (free acid)
Exact Mass: 364.02 g/mol (free acid)
CAS#: 53-83-8
Purity: ≥ 95 % (HPLC)
Form: solution in water
Concentration: 10 mM - 11 mM
pH: 7.5 ±0.5
Spectroscopic Properties: λmax 322 nm, ε 27.3 L mmol-1 cm-1 (Tris-HCl pH 7.5)
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产品组分
内容
型号
规格 储存温度
6-巯基嘌呤-核糖苷-5'-一磷酸
NU1148-01 100ul(10mM)
-20°C 6-巯基嘌呤-核糖苷-5'-一磷酸
NU1148-02 500ul(10mM)
-20°C 操作手册
1 1 常温
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营销中心
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注意事项
保存建议 厂家推荐蓝冰运输。当您收到产品后，按照说明书建议保存于-20°C。 -
FAQ
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Selected References:
Neurath et al. (2005) 6-Thioguanosine Diphosphate and Triphosphate Levels in Red Blood Cells and Response to Azathioprine Therapy in Crohns Disease. Clinical Gastroenterology and Hepatology 3 (10): 1007.
Wielinga et al. (2002)Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells. Mol Pharmacol. 62 (6):1321.
Szabados et al. (1994) 5-Aminoimidazole-4-carboxamide ribotide transformylase-IMP cyclohydrolase from human CCRFCEM leukemia cells: purification, pH dependence, and inhibitors. Biochemistry 33 (47):14237.
Stet et al. (1993) A biochemical basis for synergism of 6-mercaptopurine and mycophenolic acid in Molt F4, a human malignant T-lymphoblastic cell line. Biochim Biophys Acta. 1180 (3):277.
Drake et al. (1982) Metabolism and mechanisms of action of 9- (tetrahydro-2-furyl)-6-mercaptopurine in Chinese hamster ovary cells. Chem Biol Interact. 41 (1):105.Metabolite glues as a means of purine sensing and chemotherapeutic response.
Samuel R Witus, Megan M Kober, ..., Michael Rapé
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Patent 2′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
Gabriel Birkus, Ondrej Pav, ..., Radim Nencka
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A Role for Thiopurine Metabolites in the Synergism Between Thiopurines and Infliximab in Inflammatory Bowel Disease.
Ditte V Mogensen, Jørn Brynskov, ..., Casper Steenholdt
Journal of Crohn's and Colitis | 2018 Sep 14 | 29145599
Interactions Between Thiopurine Metabolites, Adalimumab, and Antibodies Against Adalimumab in Previously Infliximab-Treated Patients with Inflammatory Bowel Disease.
Rikke B Holmstrøm, Ditte V Mogensen, ..., Casper Steenholdt
Digestive diseases and sciences | 2018 Jun 04 | 29564674
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