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For general laboratory use.
Please centrifuge briefly before opening (volume ≤2 ml).Shipping: shipped on gel packs
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.Shelf Life: 12 months after date of delivery
Molecular Formula: C20H27N10O16P3 (free acid)
Molecular Weight: 756.41 g/mol (free acid)
Exact Mass: 756.08 g/mol (free acid)
CAS#: 5959-90-0
Purity: ≥ 95 % (HPLC)
Form: solution in water
Concentration: 10 mM - 11 mM
pH: 7.5 ±0.5
Spectroscopic Properties: λmax 259 nm, ε 27.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Specific Ligands:
Ligand for P2X and P2Y receptors:
Agonist at P2Y1 receptor[1,2,3], at P2Y12 and P2Y13 receptors[4] and for P2X1 - P2X4 purinoreceptors[5]关键词:- AP3A溶液
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产品组分
内容
型号
规格 储存温度
AP3A溶液
NU506-01 50ul(10mM)
-20°C AP3A溶液
NU506-02 250ul(10mM)
-20°C 操作手册
1 1 常温
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注意事项
保存建议 厂家推荐蓝冰运输。当您收到产品后,按照说明书建议保存于-20°C。 -
FAQ
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Selected References:
[1] Szczepanska-Konkel et al. (2005) Effects of diadenosine polyphosphates on glomerular volume. Br. J. Pharmacol. 144 (8):1109.
[2] Yerxa et al. (2001) P1- (uridine 5')-P4- (2'-deoxycytidine 5')tetraphosphate tetrasodiumsalt a next generation P2Y2 receptor agonist for treatment of cystic fibrosis. J. Pharmacol. Exp. Ther. 302:871.
[3] Ralevic et al. (2001) Structure-activity relationships of diadenosine polyphosphates (ApnAs), adenosine polyphospho guanosines (ApnGs) and guanosine polyphospho guanosines (GpnGs) at P2 receptors in the rat mesenteric arterial bed. Br. J. Pharmacol. 134 (5):1073.
[4] Zhang et al. (2002) Identification and characterization of a novel Gαi-coupled ADP receptor from human and mouse. J. Pharmacol. Exp. Ther. 301 (2):705.
[5] Gualix et al. (2014) Presence of diadenosine polyphosphates in microdialysis samples from rat cerebellum in vivo: effect of mild hyperammonemia on their receptors. Purinergic Signal. 10 (2):349.
Guranowski et al. (2000) Selective degradation of 2'-adenylated diadenosine tri- and tetraphosphates, Ap (3)A and Ap (4)A, by two specific human dinucleoside polyphosphate hydrolases. Arch. Biochem. Biophys. 373:218.
Luo et al. (1999) Identification and characterization of diadenosine 5',5'-P1,P2 -diphosphate and diadenosine 5',5'-P1,P3-triphosphate in human myocardial tissue. FASEB J. 13:695.
Luthje et al. (1988) Catabolism of Ap4A and Ap3A in whole blood. The dinucleotides are long-lived signal molecules in the blood ending up as intracellular ATP in the erythrocytes. Eur. J. Biochem. 173:241.
Luthje et al. (1987) Catabolism of Ap4A and Ap3A in human serum. Identification of isoenzymes and their partial characterization. Eur. J. Biochem. 169:385.
Luthje et al. (1985) Catabolism of Ap3A and Ap4A in human plasma. Purification and characterization of a glycoprotein complex with 5'-nucleotide phosphodiesterase activity. Eur. J. Biochem. 149:119.
Bochner et al. (1984) AppppA and related adenylylated nucleotides are synthesized as a consequence of oxidation stress. Cell 37 (1):225.Chemical proteomic profiling reveals protein interactors of the alarmones diadenosine triphosphate and tetraphosphate
Lena Krüger, Christoph J. Albrecht, ..., Andreas Marx
Nature Communications | 2021 Oct 04 | 34608152
The Internal Ribosome Entry Site of Dengue Virus mRNA Is Active When Cap-Dependent Translation Initiation Is Inhibited
Leandro Fernández-García, Jenniffer Angulo, ..., Marcelo López-Lastra
Journal of virology | 2021 Feb 10
Formation of the Alarmones Diadenosine Triphosphate and Tetraphosphate by Ubiquitin- and Ubiquitin-like-Activating Enzymes.
Kathrin H Götz, Martin Mex, ..., Andreas Marx
Cell chemical biology | 2020 Aug 27 | 31492597
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