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For general laboratory use.
Shipping: shipped on gel packs
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.Shelf Life: 12 months after date of delivery
Molecular Formula: C20H27N10O16P3 (free acid)
Molecular Weight: 756.41 g/mol (free acid)
Exact Mass: 756.08 g/mol (free acid)
CAS#: 5959-90-0
Purity: ≥ 95 % (HPLC)
Form: solid
Spectroscopic Properties: λmax 259 nm, ε 27.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Specific Ligands:
Ligand for P2X and P2Y receptors:
Agonist at P2Y1 receptor[1,2,3], at P2Y12 and P2Y13 receptors[4] and for P2X1 - P2X4 purinoreceptors[5]关键词:- AP3A固体
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产品组分
内容
型号
规格 储存温度
AP3A固体
NU5065-01 5mg
-20°C AP3A固体
NU5065-02 25mg
-20°C 操作手册
1 1 常温
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注意事项
保存建议 厂家推荐蓝冰运输。当您收到产品后,按照说明书建议保存于-20°C。 -
FAQ
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Selected References:
[1] Szczepanska-Konkel et al. (2005) Effects of diadenosine polyphosphates on glomerular volume. Br. J. Pharmacol. 144 (8):1109.
[2] Yerxa et al. (2001) P1- (uridine 5')-P4- (2'-deoxycytidine 5')tetraphosphate tetrasodiumsalt a next generation P2Y2 receptor agonist for treatment of cystic fibrosis. J. Pharmacol. Exp. Ther. 302:871.
[3] Ralevic et al. (2001) Structure-activity relationships of diadenosine polyphosphates (ApnAs), adenosine polyphospho guanosines (ApnGs) and guanosine polyphospho guanosines (GpnGs) at P2 receptors in the rat mesenteric arterial bed. Br. J. Pharmacol. 134 (5):1073.
[4] Zhang et al. (2002) Identification and characterization of a novel Gαi-coupled ADP receptor from human and mouse. J. Pharmacol. Exp. Ther. 301 (2):705.
[5] Gualix et al. (2014) Presence of diadenosine polyphosphates in microdialysis samples from rat cerebellum in vivo: effect of mild hyperammonemia on their receptors. Purinergic Signal. 10 (2):349.
Guranowski et al. (2000) Selective degradation of 2'-adenylated diadenosine tri- and tetraphosphates, Ap (3)A and Ap (4)A, by two specific human dinucleoside polyphosphate hydrolases. Arch. Biochem. Biophys. 373:218.
Luo et al. (1999) Identification and characterization of diadenosine 5',5'-P1,P2 -diphosphate and diadenosine 5',5'-P1,P3-triphosphate in human myocardial tissue. FASEB J. 13:695.
Luthje et al. (1988) Catabolism of Ap4A and Ap3A in whole blood. The dinucleotides are long-lived signal molecules in the blood ending up as intracellular ATP in the erythrocytes. Eur. J. Biochem. 173:241.
Luthje et al. (1987) Catabolism of Ap4A and Ap3A in human serum. Identification of isoenzymes and their partial characterization. Eur. J. Biochem. 169:385.
Luthje et al. (1985) Catabolism of Ap3A and Ap4A in human plasma. Purification and characterization of a glycoprotein complex with 5'-nucleotide phosphodiesterase activity. Eur. J. Biochem. 149:119.
Bochner et al. (1984) AppppA and related adenylylated nucleotides are synthesized as a consequence of oxidation stress. Cell 37 (1):225.The Polypyrimidine Tract-Binding Protein Is a Transacting Factor for the Dengue Virus Internal Ribosome Entry Site
Leandro Fernández-García, Jenniffer Angulo, ..., Alfredo Castello
Viruses | 2024 Nov 09 | 39599871
The Mytilus chilensis Steamer-like Element-1 Retrotransposon Antisense mRNA Harbors an Internal Ribosome Entry Site That Is Modulated by hnRNPK
Leandro Fernández-García, Constanza Ahumada-Marchant, ..., Stefan Weger
Viruses | 2024 Mar 05 | 38543768
Two cGAS-like receptors induce antiviral immunity in Drosophila.
Andreas Holleufer, Kasper Grønbjerg Winther, ..., Rune Hartmann
Nature | 2021 Sep 23 | 34261128
The Internal Ribosome Entry Site of Dengue Virus mRNA Is Active When Cap-Dependent Translation Initiation Is Inhibited
Leandro Fernández-García, Jenniffer Angulo, ..., Marcelo López-Lastra
Journal of virology | 2021 Feb 10
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